The Relationship between Obstructive Sleep Apnea Syndrome and Apolipoprotein E Genetic Variants

Uyrum, Ebru; Balbay, Öner; Annakkaya, Ali Nihat; Balbay, Ege Güleç; Sılan, Fatma; Arbak, Peri

doi:10.1159/000369560

Cited by 19 publications

(25 citation statements)

References 31 publications

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“…According to a study, which compared individuals with different degrees of SDB, there was no association between SDB and APOE -ε4 (18) . More existing studies found no association between APOE -ε4 and OSAS (16, 19) .…”

Section: Introductionmentioning

confidence: 88%

Examining the association between Apolipoprotein E (APOE) and self-reported sleep disturbances in non-demented older adults

Tsapanou

Scarmeas

et al. 2015

Neuroscience Letters

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We aimed to examine the association between apolipoprotein E (APOE) and sleep disturbances. This is a cross-sectional study, from the Washington Heights-Inwood Community Aging Project (WHICAP). A total of 1,944 non-demented older adults took part in the study. Sleep dysfunction was measured using sleep categories derived from the RAND Medical Outcomes Study Sleep Scale. Genetic association between APOE-ε4 genotype and sleep disturbances was assessed using unadjusted linear regression models. Secondary analyses were conducted adjusting for age, sex, education, ethnicity and body mass index (BMI). In the unadjusted model, individuals carrying the APOE-ε4 allele showed lower levels of snoring (β=−0.02, SE= 0.01, p =0.010) and sleep apnea (β=−0.01, SE= 0.01, p =0.037) when compared to non-ε4 carriers. After covariates’ adjustment, ε4 carriers demonstrated stronger association with lower levels of both snoring (β=−0.02, SE= 0.01, p=0.006), and sleep apnea (β=−0.01, SE= 0.01, p=0.018). Our results suggest that APOE-ε4 is associated with decreased problems in snoring and sleep apnea, in non-demented older adults.

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Section: Introductionmentioning

confidence: 88%

Examining the association between Apolipoprotein E (APOE) and self-reported sleep disturbances in non-demented older adults

Tsapanou

Scarmeas

et al. 2015

Neuroscience Letters

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“…After exclusions, data were extracted from 14 articles (12 in English and two in Chinese) that fulfilled the predetermined eligibility criteria. 10 – 23 Figure 1 presents a flow diagram of search strategy and study selection; Table 1 shows the characteristics of all study populations. A total of 19 study populations were available from the 14 included studies, with 3198 patients and 6031 controls.…”

Section: Resultsmentioning

confidence: 99%

Apolipoprotein E ɛ2/ɛ3/ɛ4 variant in association with obstructive sleep apnoea and lipid profile: A meta-analysis

Jin

et al. 2016

J Int Med Res

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ObjectiveA meta-analysis of the association between haplotypical variants of the apolipoprotein E (APOE) gene (ɛ2/ɛ3/ɛ4) and obstructive sleep apnoea (OSA) risk and changes in lipid profile.MethodsElectronic databases were searched to retrieve articles that provided data on APOE gene ɛ2/ɛ3/ɛ4 variants in patients with OSA and healthy controls. Data were extracted from eligible articles and statistical analyses were performed.ResultsThe meta-analysis included 14 articles involving 19 study populations (3198 patients and 6031 controls). There was no significant association between the presence of the ɛ4 allele and OSA risk. The presence of ɛ4 was associated with significantly increased total cholesterol and decreased high-density lipoprotein cholesterol, compared with ɛ4 allele negative individuals. There was a low probability of publication bias but significant heterogeneity.ConclusionsThere was no association between APOE ɛ2/ɛ3/ɛ4 and OSA susceptibility. The presence of APOE ɛ4 was associated with changes in lipid profile.

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“…Furthermore, in many children with OSAS and neurocognitive deficits, there was a high presence of ε4APOE allele, known to be present above all in people suffering from Alzheimer's disease [58]. Through magnetic resonance spectroscopy studies, it has been shown that in children with OSAS, there is a decreased hippocampal volume and focal reductions of gray matter in the frontal and parietal lobes [59,60].…”

Section: The Link Between the Severity Of Respiratory Disturbance In mentioning

confidence: 99%

Neuropsychological Alterations in Children Affected by Obstructive Sleep Apnea Syndrome

Carotenuto

Marotta

Precenzano

et al. 2021

Updates in Sleep Neurology and Obstructive Sleep Apnea

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Sleep-related breathing disorders are a group of clinical conditions ranging from habitual snoring to obstructive sleep apnea syndrome (OSAS) during the lifespan. In children, other risk factors are represented by adenotonsillar hypertrophy, rhinitis, nasal structure alteration, cleft palate, velopharyngeal flap surgery, pharyngeal masses, craniofacial malformations, genetic syndrome (i.e. Down syndrome, Crouzon syndrome, and Apert syndrome), genetic hypoplasia mandibular (i.e. Pierre Robin syndrome, Treacher Collins syndrome, Shy-Drager syndrome, and Cornelia De Lange syndrome), craniofacial traumas, chronic or seasonal rhinitis, asthma, neuromuscular syndromes, brainstem pathologies (i.e. Arnold-Chiari malformation and Joubert syndrome), achondroplasia, and mucopolysaccharidosis. OSAS may affect the executive functioning such as motivational ability, planning, behavior modulation, ability to complete an action program, identification of functional strategies to achieve the goal, problem solving, flexibility, monitoring and self-assessment of behavior in relation to results, change of task, or behavior in the light of emerging information, which may be all impaired by nocturnal intermittent hypoxia also during the developmental age. The clinical presentation of OSAS can mimic other neurobehavioral symptoms, such as ADHD syndrome, learning problems, or can exacerbate the Fragile X syndrome, and generalized nonconvulsive epilepsy symptoms.

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The Relationship between Obstructive Sleep Apnea Syndrome and Apolipoprotein E Genetic Variants

Cited by 19 publications

References 31 publications

Examining the association between Apolipoprotein E (APOE) and self-reported sleep disturbances in non-demented older adults

Examining the association between Apolipoprotein E (APOE) and self-reported sleep disturbances in non-demented older adults

Apolipoprotein E ɛ2/ɛ3/ɛ4 variant in association with obstructive sleep apnoea and lipid profile: A meta-analysis

Neuropsychological Alterations in Children Affected by Obstructive Sleep Apnea Syndrome

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