The relationship between neutrophil/lymphocyte ratio and uric acid levels in multiple sclerosis patients

Abstract

BACKGROUND: In this study, we aimed to determine whether neutrophil / lymphocyte ratio (NLR), obtained by dividing the number of neutrophils by the number of lymphocytes, and uric acid (UA) levels in multiple sclerosis (MS) patients vary compared with healthy controls and to establish correlations among these changes themselves as well as between such changes and MS subtypes, immunomodulatory drug use, the duration of the disease and prognosis. METHODS: 150 patients who presented to our hospital and were diagnosed with MS and 150 healthy volunteers were retrospectively included in our study. EDSS score (Expanded Disability Status Scale) was used to assess the disability of the patients. RESULTS: Compared to healthy volunteers, MS patients had lower UA levels (p < 0.001) and higher NLR values (p = 0.02). In addition, UA levels were higher in patients with a low EDSS score or those on immunomodulating drugs (p < 0.001, p = 0.04, respectively). NLR value was lower in patients with a low EDSS score (p < 0.001). There was a negative correlation between NLR value and UA (r = -0.23, p = 0.003). Similarly, UA level decreased with increasing EDSS score and duration of disease (r = -0.38, p < 0.001; r = -0.17, p = 0.02, respectively). CONCLUSION: Evaluating the NLR value, recognized as a new marker for infl ammation in MS, together with the UA value, thought to be protective in MS, might be more effective than evaluating these parameters alone in demonstrating disability in patients (Tab. 4, Ref. 28).

Elevated Serum Uric Acid Increases the Risk of Ischemic Stroke Recurrence and Its Inflammatory Mechanism in Older Adults

“…However, the relationship between UA and NLR remains controversial. For example, in a study of multiple sclerosis, NLR was found to be negatively correlated with UA ( Bolayir et al, 2021 ). The same study also found that co-assessment of NLR and UA may be more effective than assessing these parameters individually in demonstrating disability in multiple sclerosis patients.…”

“…And it is a simple, inexpensive, and useful tool to indicate subclinical low-grade inflammation in many systemic circumstances ( Taşoğlu et al, 2016 ). The UA level is closely related to inflammation indicators ( Ruggiero et al, 2006 ; Kocaman et al, 2009 ; Liu et al, 2019 ; Bolayir et al, 2021 ); for example, a community-based study showed that inflammation indicators are positively correlated with UA, and this association is independent of the usual risk factors for chronic kidney disease (CKD) ( Liu et al, 2019 ). However, the relationship among ischemic stroke recurrence, UA level and NLR is not clear.…”

Uric Acid and Oxidative Stress—Relationship with Cardiovascular, Metabolic, and Renal Impairment

“…Other current pathogenesis incriminated in the onset and progression of already mentioned diseases are epithelial-to-mesenchymal transition in renal tubular cells, renal vasoconstriction mediated by endothelial dysfunction, and activation of renin-angiotensin system (RAAS) [ 12 ]. Some studies reported that high levels of uric acid may exert protective effects in neurological disorders, such as Parkinson’s disease [ 13 ], multiple sclerosis [ 14 , 15 ], Alzheimer’s disease [ 16 ], and vascular-disease-related dementia [ 2 ] through its extracellular anti-oxidative role. In contrast, some researchers sustain the hypothesis that deterioration of kidney function associated with hyperuricemia might be due to co-existing conditions, such as vascular calcifications, hypertension, and obesity [ 17 ].…”

Investigation of the relationship between inflammatory blood parameters and seborrheic dermatitis

“…RDW, PLR, MLR, MPV, RDW, NLR, and SII were calculated by using CBC parameters. These parameters are used as new inflammatory markers, which are considered as cost-effective and simple laboratory parameters indicating systemic inflammation in many diseases.. 5,13,14 This study aimed to explore inflammatory and CBC parameters in patients with SD and evaluate their possible relationship with disease severity (SDASI). To the best of our knowledge, this study is the first to investigate the relationship between disease severity and these markers.…”

“…These parameters are used as new inflammatory markers, which are considered as cost‐effective and simple laboratory parameters indicating systemic inflammation in many diseases. 5,13,14 …”