The relationship between MRI and PET changes and cognitive disturbances in MS

Sørensen, Per Soelberg; Jønsson, A.; Mathiesen, Henrik Kahr; Blinkenberg, Morten; Andresen, Jente; Hanson, Lars G.; Ravnborg, Mads

doi:10.1016/j.jns.2005.09.020

Cited by 15 publications

(6 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…39 Fatigue and cognitive function are associated with decreased brain metabolism in MS patients. 40, 41 This study presents multi-gene evidence for IFNβ-1b regulation of mitochondrial function, in particular metabolic processes that control the balance of fatty acids and their derivative biomolecules. Mitochondrial dysfunction and neuroprotection in MS is extensively reviewed in Mao and Reddy 39 and Guzmán and Blázquez.…”

Section: Discussionmentioning

confidence: 97%

Interferon-beta-1b-induced short- and long-term signatures of treatment activity in multiple sclerosis

Croze

Yamaguchi²,

Knappertz

et al. 2012

Pharmacogenomics J

View full text Add to dashboard Cite

Interferon beta (IFNβ) reduces disease burden in relapsing-remitting multiple sclerosis (MS) patients. In this study, IFNβ-1b-treated MS patient gene expression profiles and biological knowledgebases were integrated to study IFNβ's pleiotropic mechanisms of action. Genes involved in immune regulation, mitochondrial fatty acid metabolism and antioxidant activity were discovered. Plausible mediators of neuronal preservation included NRF2, downregulation of OLA1, an antioxidant suppressor, and the antioxidant gene ND6, implicated in optic neuropathy and MS-like lesions. Network analysis highlighted IKBKE, which likely has a role in both viral response and energy metabolism. A comparative analysis of therapy-naive MS- and IFNβ-associated gene expression suggests an IFNβ insufficiency in MS. We observed more gene expression changes in long-term treatment than during acute dosing. These distinct short- and long-term effects were driven by different transcription factors. Multi-gene biomarker signatures of IFNβ treatment effects were developed and subsequently confirmed in independent IFNβ-1b-treated MS studies, but not in glatiramer acetate-treated patients.

show abstract

Section: Discussionmentioning

confidence: 97%

Interferon-beta-1b-induced short- and long-term signatures of treatment activity in multiple sclerosis

Croze

Yamaguchi²,

Knappertz

et al. 2012

Pharmacogenomics J

View full text Add to dashboard Cite

show abstract

“…One might parallel observations from multiple sclerosis, where to some extent lesion load in the cerebral white matter is related to cognitive function. 34 To the best of our knowledge, there is the lack of comparative studies and studies defining a threshold in MS lesion load for cognitive decline. There are studies addressing timing of brain insult and functional deficits in children with brain lesions occurring at different ages, which interpret their findings in favor of a higher vulnerability during early brain development, as functional outcome was found to be poorer after early insults.…”

Section: Neuroplasticity and Bilateral Lesionsmentioning

confidence: 99%

Plasticity during Early Brain Development Is Determined by Ontogenetic Potential

et al. 2017

View full text Add to dashboard Cite

Two competing hypotheses address neuroplasticity during early brain development: the "Kennard principle" describes the compensatory capacities of the immature developing CNS as superior to those of the adult brain, whereas the "Hebb principle" argues that the young brain is especially sensitive to insults. We provide evidence that these principles are not mutually exclusive. Following early brain lesions that are unilateral, the brain can refer to homotopic areas of the healthy hemisphere. This potential for reorganization is unique to the young brain but available only when, during ontogenesis of brain development, these areas have been used for the functions addressed. With respect to motor function, ipsilateral motor tracts can be recruited, which are only available during early brain development. Language can be reorganized to the right after early left hemispheric lesions, as the representation of the language network is initially bilateral. However, even in these situations, compensatory capacities of the developing brain are found to have limitations, probably defined by early determinants. Thus, plasticity and adaptivity are seen only within ontogenetic potential; that is, axonal or cortical structures cannot be recruited beyond early developmental possibilities. The young brain is probably more sensitive and vulnerable to lesions when these are bilateral. This is shown here for bilateral periventricular white matter lesions that clearly have an impact on cortical architecture and function, thus probably interfering with early network building.

show abstract

“…In vivo studies are required to investigate these early stages and to assess the efficacy of putative neuroprotective agents. The first positron emission tomography (PET) studies in patients with MS have been conducted more than 20 years ago and sought to assess specific metabolic patterns [3] and to relate these patterns to symptoms of the disease, like cognitive impairment [4] disability [5], and fatigue [6]. Then, the increasing definition of magnetic resonance imaging (MRI) and the advent of new MRI techniques have secured a prominent attention and investment in this field of research.…”

Section: Introductionmentioning

confidence: 99%

Positron emission tomography imaging in multiple sclerosis–current status and future applications

Kiferle

Politis

Muraro

et al. 2011

Euro J of Neurology

View full text Add to dashboard Cite

show abstract

The relationship between MRI and PET changes and cognitive disturbances in MS

Cited by 15 publications

References 22 publications

Interferon-beta-1b-induced short- and long-term signatures of treatment activity in multiple sclerosis

Interferon-beta-1b-induced short- and long-term signatures of treatment activity in multiple sclerosis

Plasticity during Early Brain Development Is Determined by Ontogenetic Potential

Positron emission tomography imaging in multiple sclerosis–current status and future applications

Contact Info

Product

Resources

About