The Relationship Between Microvascular Complications in Type 2 Diabetes with Mean Platelet Volume, Red Blood Cell Distribution Width, Neutrophile Lymphocyte Ratio

Sayıner, Zeynel Abidin; Eraydın, Ayten; Atakur, Selman; Özkaya, Mesut

doi:10.5336/intermed.2017-57111

Cited by 3 publications

(5 citation statements)

References 13 publications

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“…The combined effect of peripheral arterial disease and neuropathy is one of the most common causes of DFU. 32 Sayıner et al 18 reported that RDW, mean platelet volume, and NLR can be used as an indicator of risk increase in microvascular complications of diabetes. Malandrino et al 33 found a significant relationship between high RDW levels and macrovascular complications (myocardial infarction, heart failure, and stroke) in a group of diabetic and nondiabetic patients.…”

Section: Discussionmentioning

confidence: 99%

“…17 The literature has shown that RDW is useful in predicting microvascular complications in diabetic patients such as NLR. 18 The aim of this study was to investigate the predictive values of NLR and RDW for the prognosis of DFU treatment.…”

Section: Introductionmentioning

confidence: 99%

“…17 The literature has shown that RDW is useful in predicting microvascular complications in diabetic patients such as NLR. 18…”

Section: Introductionmentioning

confidence: 99%

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Monitoring the Prognosis of Diabetic Foot Ulcers: Predictive Value of Neutrophil-to-Lymphocyte Ratio and Red Blood Cell Distribution Width

Arıcan

Kahraman

Özmeriç

et al. 2020

The International Journal of Lower Extremity Wounds

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The aim of this study was to investigate the prognostic values of neutrophil-to-lymphocyte ratio and red blood cell distribution width in diabetic foot ulcers treatment. A total of 250 adult patients who were treated in our clinic between 2007 and 2018 for diabetic foot ulcers were evaluated retrospectively. Diabetic foot ulcers were divided into 4 groups: major amputation, minor amputation, chronic wound, and complete healing. The mean age of our study groups was 60 years (range = 55-65 years). The mean follow-up period was 28 ± 4.3 months. Neutrophil-to-lymphocyte ratio and red blood cell distribution width cutoff values were determined as 4.3 and 12.1, respectively, for patients in complete recovery group (C sig. = .995 and .871, respectively; P < .05). Neutrophil-to-lymphocyte ratio and red blood cell distribution width cutoff values for patients in the major amputation group were 6.73 and 13.4 (C sig. = .864 and .951, respectively; P < .05), respectively. According to the χ2 comparison of the groups, major amputation was seen in patients with neutrophil-to-lymphocyte ratio >6.3, and complete recovery was seen in patients with neutrophil-to-lymphocyte ratio <4.3. In patients with red blood cell distribution width >13.4, major amputation was found to be significant ( P < .05). According to these results, neutrophil-to-lymphocyte ratio and red blood cell distribution width are inexpensive and easy to access predictive parameters in the diagnosis and follow-up of diabetic foot ulcers.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Monitoring the Prognosis of Diabetic Foot Ulcers: Predictive Value of Neutrophil-to-Lymphocyte Ratio and Red Blood Cell Distribution Width

Arıcan

Kahraman

Özmeriç

et al. 2020

The International Journal of Lower Extremity Wounds

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“…High NLR results in neutrophilic hyperactivity, which leads to endothelial damage and dysfunction 62 . NLR may be an indicator of increased risk of microvascular complications of diabetes 63 , and the relationship between high NLR and amputation risk may be associated with this vascular mechanism independent of osteomyelitis, which may be an additional factor that contributes to this relationship.…”

Section: Patient Characteristicsmentioning

confidence: 99%

Evaluation of osteomyelitis in diabetic foot ulcers with exposed bone

Derebaşınlıoğlu¹,

Aksoy²

2023

WPR

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Purpose Exposed bone and periosteal damage promote the adherence of pathogens to bone matrix components. Damage to the periosteum adversely affects bone perfusion and creates a more suitable environment for pathogens. The purpose of this study was to determine the prevalence of osteomyelitis among patients with diabetic foot ulcers with bone exposure and to identify the role of simple serological markers in the diagnosis of osteomyelitis in this patient group.Methods Patients who underwent amputation and debridement due to diabetes-related foot wound were included in the study. The pathology results were evaluated according to presence of osteomyelitis. C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), complete blood count (CBC), platelet/lymphocyte ratio, neutrophil/lymphocyte ratio (NLR) and microbial growth were analysed.Results Patients with ESR of 79mm/h or lower had a 3.046-fold higher risk of osteomyelitis. The risk of osteomyelitis was 2.901-fold higher at lymphocyte percentages of 12.3% or higher. Patients with a neutrophil percentage of 78% or lower had a 3.010-fold higher risk of osteomyelitis. Patients with NLR of 6.02 or lower had a 2.901-fold risk of osteomyelitis. When ESR was evaluated with neutrophil percentage, lymphocyte percentage and NLR, the sensitivity was calculated as 86.76% for osteomyelitis. ConclusionWe believe that the immune response caused by bone exposure to the environment is different than the immune response caused by soft tissue infection in the classical diabetic foot. The combined evaluation of multiple diagnostic parameters increases the sensitivity of osteomyelitis diagnosis.

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“…Similarly, researchers consider that RDW increases due to secondary inflammatory response. 6,7 According to these reports of previous studies, we assumed that inflammatory markers will increase in DM, as it is characterized by subclinical inflammation. We aimed to compare the hemogram parameters of newly diagnosed, type 2 diabetic patients with low HbA1c levels with nondiabetic and prediabetic patients.…”

Section: Introductionmentioning

confidence: 99%

İnflamasyonla İlişkili Hemogram Parametreleri Diyabetes Mellitusun Bir Göstergesi Olabilir Mi?

Sözen

Çetinaslan

Cantürk

et al. 2021

Kocaeli Üniversitesi Sağlık Bilimleri Dergisi

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Objective: Subclinical chronic inflammation plays an important role in the pathogenesis of type 2 diabetes mellitus (DM) and inflammation-related hemogram parameters have been proposed as an indicator of inflammation. In our study, we aimed to compare the hemogram parameters of normal oral glucose tolerance test (OGTT), prediabetes (preDM) and newly diagnosed type 2 DM patients. Methods: Medical data of the patients who underwent 75 gr OGTT in the endocrinology outpatient clinic of our institution between february 2019 and december 2019 were obtained from the database and analyzed retrospectively. The test results were divided into 3 groups as normal OGTT, preDM and DM. Anthropometric measurements of patients, HbA1c and hemogram parameters were recorded. Results: A total of 496 cases (246 normal OGTT, 105 patients with preDM and 145 patients with DM) were included in the study. Fasting plasma glucose (FPG) and HbA1c levels of men were higher than women (p<0.05). There was no significant difference between the three groups in terms of inflammation-related hemogram parameters. But, there was a positive correlation between FPG and MPV to platelet ratio (MPR) in diabetic patients (r=0.173; p=0.037). Conclusion:Hemogram parameters associated with inflammation are easily calculated and cheap indices. However, they are not strong markers in new diagnosis, HbA1c ≤6.5% diabetic patients and prediabetic patients.

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The Relationship Between Microvascular Complications in Type 2 Diabetes with Mean Platelet Volume, Red Blood Cell Distribution Width, Neutrophile Lymphocyte Ratio

Cited by 3 publications

References 13 publications

Monitoring the Prognosis of Diabetic Foot Ulcers: Predictive Value of Neutrophil-to-Lymphocyte Ratio and Red Blood Cell Distribution Width

Monitoring the Prognosis of Diabetic Foot Ulcers: Predictive Value of Neutrophil-to-Lymphocyte Ratio and Red Blood Cell Distribution Width

Evaluation of osteomyelitis in diabetic foot ulcers with exposed bone

İnflamasyonla İlişkili Hemogram Parametreleri Diyabetes Mellitusun Bir Göstergesi Olabilir Mi?

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