The aim of this study was to investigate the prognostic values of neutrophil-to-lymphocyte ratio and red blood cell distribution width in diabetic foot ulcers treatment. A total of 250 adult patients who were treated in our clinic between 2007 and 2018 for diabetic foot ulcers were evaluated retrospectively. Diabetic foot ulcers were divided into 4 groups: major amputation, minor amputation, chronic wound, and complete healing. The mean age of our study groups was 60 years (range = 55-65 years). The mean follow-up period was 28 ± 4.3 months. Neutrophil-to-lymphocyte ratio and red blood cell distribution width cutoff values were determined as 4.3 and 12.1, respectively, for patients in complete recovery group (C sig. = .995 and .871, respectively; P < .05). Neutrophil-to-lymphocyte ratio and red blood cell distribution width cutoff values for patients in the major amputation group were 6.73 and 13.4 (C sig. = .864 and .951, respectively; P < .05), respectively. According to the χ2 comparison of the groups, major amputation was seen in patients with neutrophil-to-lymphocyte ratio >6.3, and complete recovery was seen in patients with neutrophil-to-lymphocyte ratio <4.3. In patients with red blood cell distribution width >13.4, major amputation was found to be significant ( P < .05). According to these results, neutrophil-to-lymphocyte ratio and red blood cell distribution width are inexpensive and easy to access predictive parameters in the diagnosis and follow-up of diabetic foot ulcers.

Three-point index (TPI), which can be used in the follow-up of conservative treatment, is an important indicator and reveals objective results about the fracture redisplacement. The hypothesis of the current study was that an initial TPI value of 0.6-0.8 may also be dangerous as it has the potential to exceed over 0.8 before a sufficient consolidation occurs and a prompt revision of the cast may prevent an upcoming displacement. This prospective controlled study 84 patients between 4 and 16 years of age, with radius distal metaphyseal fractures with more than 30% displacement or more than 15° initial angulation, were included. All of the patients in the groups had no redisplacement at 5-7 days and had TPI between 0.6 and 0.8. The patients who had cast replacement and adjusted TPI below 0.6 were included Group 1. The patients who had no cast replacement were included in Group 2. Redisplacement was observed in 8 of 38 (21%) patients in the Group 1 and in 27 of 46 (58%) patients in the Group 2 (P value 0.001). Redisplacement with cast revision was 2.8 times less (P < 0.005). The first reduction quality, fracture obliquity, renewed TPI values were found to be statistically significant for the prediction of redisplacement (P < 0.005). We recommend that the follow-up of the TPI is an important predictive factor in the conservative treatment of pediatric metaphyseal radius fractures. TPI may be renewed for protection of the fracture reduction when calculated in the gray zone which is 0.6-0.08.

IntroductionAseptic loosening is one of the most important complications of arthroplasty surgery. It is known that immune response against particles plays role in the pathogenesis of aseptic loosening. Polyethylene (PE) has an important place in these particles. There are limited in vivo studies examining aseptic loosening caused by PE residues.

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