The relationship between microalbuminuria, overweight and obesity

Hemayati, Roya; Kaseb, Fatemeh; Ghadiri‐Anari, Akram

doi:10.34172/jnp.2020.41

Cited by 8 publications

(4 citation statements)

References 29 publications

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“…Concerning the relationship between gender and microalbuminuria levels, this study showed a significant difference among obese and normal-weight girls but not among boys. In contrast, Hemayati et al (26) found that the prevalence of microalbuminuria was 11% and was significantly higher in men than women. Rutkowski et al, (27) also found that microalbuminuria was higher in men than women.…”

Section: Discussionmentioning

confidence: 86%

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Urine Microalbumin in Obese Comparing with Healthy Children

Khalili

Sadeghi‐Bojd

Teimouri

et al. 2020

CJHR

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Background: Obesity is a global problem and is associated with pathophysiological mechanisms related to kidneys which may result in microalbuminuria. The aim of this study was to compare the microalbuminuria in obese and normal-weight children. Methods: In this descriptive analytical study, 200 children in two groups of obese and normalweight investigated. Children who met the study criteria were enrolled and their age, gender and BMI were recorded. Then levels of urinary albumin and creatinine were measured and albuminto-creatinine ratio were calculated. The two groups were compared using chi-square and t-test. Results: In this study, 45% of obese children and 52% of normal children were boys. In terms of gender and age group, there was no significant difference between the two groups (P-value = 0.396 for gender and P-value = 0.502 for age-group). The overall prevalence of microalbuminuria in the study population was 8.5%. The prevalence in obese children (13%) was more than normal-weight children (4%) (P-value = 0.040). Further analysis stratified by sex and age-group showed a higher significant mean value of urine microalbuminuria in obese compared to normal-weight children among girls (P-value = 0.004) and among children in 12-19 years of age (P-value = 0.033). Conclusion: The results of this study showed that the obesity in children is associated with higher prevalence of microalbuminuria.

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Section: Discussionmentioning

confidence: 86%

“…Rutkowski et al, (27) also found that microalbuminuria was higher in men than women. Obesityrelated glomerulopathy presented clinically by microalbuminuria and may increase tenfold over 15 years (26). The development of increased albumin excretion rates is associated not only with hyperglycemia but also with blood pressure elevations (28).…”

Section: Discussionmentioning

confidence: 99%

Urine Microalbumin in Obese Comparing with Healthy Children

Khalili

Sadeghi‐Bojd

Teimouri

et al. 2020

CJHR

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“…Body mass index (BMI) and waist-to-hip ratio (WHR) have been significantly associated with microalbuminuria [10]. The specific pathogenesis regarding obesity-related glomerulopathy is hyperfiltration, which is mediated by excessive protein and salt intake, high blood insulin levels, and increased feedback of the tubuloglomerular component.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Microalbuminuria and Cardiovascular Risk Factors in Patients With Diabetes Mellitus Type-II in Al-Khobar, Kingdom of Saudi Arabia

Jatoi¹,

Said²,

Al-Ghamdi³

et al. 2022

Cureus

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“…[16,17] A reduction in central obesity should be emphasized as a key component for the prevention of vascular and renal function decline. [18,19] . The term 'insulin resistance' refers to a decrease in a target cell's metabolic response to insulin, or, at the whole-organism level, an impaired lowering effect of circulating or injected insulin on blood glucose.…”

Section: Introductionmentioning

confidence: 99%

Role of Microalbuminuria and Insulin Resistance as Predictive Biomarkers for Nephropathy in Obese Individuals – A Study Protocol

Jha

Dhok

Shukla

et al. 2021

JPRI

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Background: Obesity is a compounded, multifactorial, and largely curable disease, affecting over a third of the public community today. The World Health Organization (WHO) has declared obesity as a global epidemic, also stressing that in many cases it remains an under-recognized problem of the public health agenda. It is a global health concern and a major risk factor for diabetes, hypertension, and dyslipidemia, which may lead to decrease in renal function and ultimately obesity related nephropathy. As per, the epidemiological and experimental data have indicated, microalbuminuria (MAU) is an early marker of target organ damage and is associated with all-cause mortality, cardiovascular diseases (CVDs) incidence, and progression of nephropathy in non-diabetic subjects. Insulin resistance is present in obese individuals. Obesity related insulin resistance may arise from defects in fatty acid oxidation, and secondary β-cell lipotoxicity. The present study is a Cross-sectional analytical observational study; the study will be carried out in the Dept. of Biochemistry at Jawaharlal Nehru Medical College, ABV Rural Hospital, Sawangi (M), Wardha. Participants will be outpatients of this institution. Any participant fulfilling the eligibility criteria will be included in the study. Protocol amendments are not expected. However, if necessary, any modification to the protocol will be reported to the entire investigational team through a conference. All changes will be included in the final manuscript prior to submission. Aim and Objectives: Present study is targeted to assess role and correlation of microalbuminuria and insulin resistance as predictive biomarkers for nephropathy in obese subjects. Implications: Present study will be helpful to decrease morbidity and mortality, specifically associated with comprised renal status and prevent nephropathy. The study will be helpful to detect early clinicopathological phase of comprised renal status. Conclusion: The purpose of this study is to investigate role of microalbuminuria and insulin resistance as predictive markers of nephropathy in obese individuals.

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The relationship between microalbuminuria, overweight and obesity

Cited by 8 publications

References 29 publications

Urine Microalbumin in Obese Comparing with Healthy Children

Urine Microalbumin in Obese Comparing with Healthy Children

Prevalence of Microalbuminuria and Cardiovascular Risk Factors in Patients With Diabetes Mellitus Type-II in Al-Khobar, Kingdom of Saudi Arabia

Role of Microalbuminuria and Insulin Resistance as Predictive Biomarkers for Nephropathy in Obese Individuals – A Study Protocol

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