The Relationship between Maternal Atopy and Childhood Asthma in Pretoria, South Africa

Abbott, Salome; Becker, Piet J.; Green, Robin J.

doi:10.1155/2013/164063

Cited by 3 publications

(3 citation statements)

References 8 publications

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“…These included the maternal demographics of: age at pregnancy onset, race, insurance status, tobacco use, asthma, atopy, chronic diabetes, hypertension, preeclampsia, and gestational diabetes. We also evaluated the gender of baby and cesarean section delivery as they have been reported to have associations with childhood asthma in previous studies . We utilized a change‐in‐estimate variable selection strategy, that is, those covariate or covariate combinations that changed the regression coefficients for BMI approximately 10% or more, or were demonstrated in the literature to be important confounders or covariates (e.g., cesarean section deliveries), were retained in the fully adjusted model (Model 2) .…”

Section: Methodsmentioning

confidence: 99%

Maternal body mass index before pregnancy is associated with increased bronchodilator dispensing in early childhood: A cross‐sectional study

MacDonald

Vesco

Funk

et al. 2016

Pediatric Pulmonology

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Rationale Maternal prepregnancy obesity has been associated with early wheeze and childhood asthma in their offspring. Some of these studies have been in minority, urban, and disadvantaged populations using parental recall and questionnaires. The association of maternal prepregnancy obesity with bronchodilator dispensing to their offspring, in a primarily insured, non-urban, White population in the United States is unknown. Objectives and Methods We conducted a retrospective cohort study using pharmacy dispensing data from the electronic medical records of a large United States health maintenance organization to examine the relationship between maternal prepregnancy body mass index (BMI) and inhaled bronchodilator dispensing in the offspring to four years of age. We included infants ≥ 37 weeks’ gestation with birth weight ≥ 2.5 kg which yielded 6,194 mother-baby pairs. Maternal prepregnancy BMI was categorized as underweight (< 18.5 kg/m2), normal (18.5–24.9 kg/m2), overweight (25–29.9 kg/m2), or obese (≥ 30 kg/m2). Results In the entire cohort, 27.6% of the offspring received a bronchodilator dispensing. This ranged from 19.2% in the offspring of underweight mothers to 31.3% of those born to obese mothers. In the fully adjusted model using normal BMI as the referent, children of obese mothers had a 22% higher rate of bronchodilator dispensing (adjusted OR = 1.22; 95% CI 1.05–1.41; p=0.008). Conclusions In this insured, non-urban, White population, maternal prepregnancy obesity was associated with bronchodilator dispensing in the offspring in early life. These results extend previous data and reaffirm the potential widespread public health impact that prepregnancy obesity may have on subsequent childhood respiratory health.

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Section: Methodsmentioning

confidence: 99%

Maternal body mass index before pregnancy is associated with increased bronchodilator dispensing in early childhood: A cross‐sectional study

MacDonald

Vesco

Funk

et al. 2016

Pediatric Pulmonology

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“…The complex interaction between genetic, and nongenetic factors plays a role in the pathogenesis of asthma, as the occurrence of family history, especially among firstdegree relatives, elevates the risk of asthma development. Demographic factors such as sex and obesity, and environmental factors such as smoking history and exposure to air pollution also had a role [26][27][28][29][30][31][32][33].…”

Section: Discussionmentioning

confidence: 99%

Estimation of Atopy and Allergies Among Sudanese Children with Asthma

Elgadal¹,

Nail²

2023

Sudan JMS

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Background: Bronchial asthma is a chronic respiratory problem characterized by a reversible hyper-responsive airway obstruction that is provoked by allergens, infections, or nonspecific triggers. The study aims to assess the coexistence of atopy and allergies among children with asthma.Methods: This single-center study was conducted at Mohamed El-Amin H. Hospital, Sudan. A free online sample size calculator was used. A specially designed form was used for data collection. Data were analyzed using the SPSS version 20.0.Results: A total of 300 participants were enrolled in the study, with a mean age of 7.46 ± 3.93 years. The male-to-female ratio was 1.3:1. A total of 215 (71.6%) children had a family history of asthma; atopy was allergic rhinitis in 108 (36%), eczema in 53 (17.7%), food allergy in 38 (14%), and allergic conjunctivitis in 29 (9.7%). A significant association was observed between male gender and family history of asthma, atopy, and coexisting personal history of atopy, P = 0.002, 0.004, and 0.001, respectively. All participants who had atopy had allergic rhinitis; 53 (49%) had atopic dermatitis, 29 (26.8%) had coexisting allergic conjunctivitis, and food allergies were found in 38 (35.2%) participants. Common food allergies found were eggplants, fish, cow milk, and banana. Atopy and allergies were common among those who were 6–10 years old, however, only allergic rhinitis was statistically significant with age (P = 0.021).Conclusion: Combined family history of asthma and atopy was common, few had atopy only, and fewer had neither family history nor atopy. Atopy found was allergic rhinitis, conjunctivitis, eczemas, and food allergy.

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“…A number of factors including prenatal and postnatal exposure to allergic triggers have been identified to increase the susceptibility to asthma 14 – 16 . However, maternal allergies are poor predictors of childhood atopic asthma 17 . Conversely, in the present study, children born with lower Th2 responses appeared to be at higher risk for childhood asthma.…”

Section: Discussionmentioning

confidence: 99%

Low Mother-to-Child CCL22 Chemokine Levels Are Inversely Related to Mite Sensitization and Asthma in Early Childhood

Chiu

Tsai

et al. 2018

Sci Rep

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Few studies have addressed the mother-to-child transmission of Th2 immunity and the impact on the development of atopic diseases in early childhood. We investigated 186 children who were followed-up regularly for 4 years in a birth cohort study. The levels of Th2 related chemokine (C-C motif) ligand 17 (CCL17) and CCL22 were quantified in cord blood and at 1.5 years-of-age using multiplex Luminex kits. The levels of 125 pairs of CCL17 and CCL22 chemokines from birth to 1.5 years were recorded in this study. Using K-means clustering, only the declining trend of CCL22 levels was separately clustered (cluster A, n = 51; cluster B, n = 46; cluster C, n = 28). Mothers of children with higher CCL22 chemokine levels at birth were significantly more likely to display Dermatophagoides pteronyssinus sensitization. A lower CCL22 level at birth with a slight rise during infancy was associated with higher prevalence of mite sensitization and a higher risk of asthma at 3 years-of-age (P = 0.014). In conclusion, low mother-to-child Th2-associated chemokine CCL22 levels appear to be inversely related to mite sensitization and the risk of asthma development in early childhood.

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The Relationship between Maternal Atopy and Childhood Asthma in Pretoria, South Africa

Cited by 3 publications

References 8 publications

Maternal body mass index before pregnancy is associated with increased bronchodilator dispensing in early childhood: A cross‐sectional study

Maternal body mass index before pregnancy is associated with increased bronchodilator dispensing in early childhood: A cross‐sectional study

Estimation of Atopy and Allergies Among Sudanese Children with Asthma

Low Mother-to-Child CCL22 Chemokine Levels Are Inversely Related to Mite Sensitization and Asthma in Early Childhood

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