The relationship between local field potential and neuronal discharge in the subthalamic nucleus of patients with Parkinson's disease

Kühn, Andrea A.; Trottenberg, Thomas; Kivi, Anatol; Kupsch, Andreas; Schneider, Gerd‐Helge; Brown, Peter

doi:10.1016/j.expneurol.2005.02.010

Cited by 358 publications

(270 citation statements)

References 27 publications

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“…Other limitations are the presumptive localization of electrode contacts in the STN (Williams et al, 2002;Fogelson et al, 2006) and the possibility that power changes picked up at the bipolar contacts of the DBS electrode are not really focally generated. Against the latter, we found a steep gradient in LFP power in the beta band across different bipolar contact pairs consistent with a local generator (Kühn et al, 2004(Kühn et al, , 2006, although the strongest argument in favor of the local generation of beta activity in the LFP is the demonstration that the discharge of neurons in the STN tends to be locked to it (Levy et al, 2002;Kühn et al, 2005). A more specific limitation in the current study is that the paradigm was not designed to evaluate whether beta activity was modulated by the temporal expectancy of the imperative cue.…”

Section: Discussionmentioning

confidence: 84%

Beta Reactivity, Prospective Facilitation of Executive Processing, and Its Dependence on Dopaminergic Therapy in Parkinson's Disease

Oswal¹,

Litvak²,

Sauleau³

et al. 2012

Journal of Neuroscience

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Oscillatory activity in the beta frequency band has been shown to be modulated during the preparation and execution of voluntary movements at both cortical and subcortical levels. The exaggeration of beta activity in the basal ganglia of patients with Parkinson's disease has heightened interest in this phenomenon. However, the precise function, if any, subserved by modulations in beta activity remains unclear. Here we test the hypothesis that beta reactivity can be dissociated from processing of specific actions and can index the salience of cues with respect to future behavior in a way that might help prospectively prioritize resources. To this end we used an experimental paradigm designed to dissociate salient warning cues from processing of specific motor or cognitive actions. We recorded local field potential activity from the subthalamic nucleus of humans undergoing functional neurosurgery for the treatment of Parkinson's disease, while the same patients were on or off the dopamine prodrug levodopa. In this way we demonstrate that beta reactivity is indeed dependent on the salience of cues with respect to future motor and cognitive action and is promoted by dopamine. The loss of normal beta encoding of saliency may underlie some of the motor and cognitive features of basal ganglia disorders such as Parkinson's disease.

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Section: Discussionmentioning

confidence: 84%

Beta Reactivity, Prospective Facilitation of Executive Processing, and Its Dependence on Dopaminergic Therapy in Parkinson's Disease

Oswal¹,

Litvak²,

Sauleau³

et al. 2012

Journal of Neuroscience

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“…In patients with PD, oscillatory synchronization tends to occur at frequencies of ϳ20 Hz, in the so-called ␤ band (Hammond et al, 2007). Generally this synchronization has been inferred from oscillations in local field potentials (LFPs), and several lines of evidence support the use of such activity as a surrogate measure of neuronal synchrony in the basal ganglia (Levy et al, 2002;Brown and Williams, 2005;Kühn et al, 2005;Weinberger et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

High-Frequency Stimulation of the Subthalamic Nucleus Suppresses Oscillatory Activity in Patients with Parkinson's Disease in Parallel with Improvement in Motor Performance

Kühn¹,

Kempf²,

Brücke³

et al. 2008

Journal of Neuroscience

744

582

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High-frequency stimulation (HFS) of the subthalamic nucleus (STN) is a well-established therapy for patients with severeParkinson's disease (PD), but its mechanism of action is unclear. Exaggerated oscillatory synchronization in the ␤ (13-30 Hz) frequency band has been associated with bradykinesia in patients with PD. Accordingly, we tested the hypothesis that the clinical benefit exerted by STN HFS is accompanied by suppression of local ␤ activity. To this end, we explored the after effects of STN HFS on the oscillatory local field potential (LFP) activity recorded from the STN immediately after the cessation of HFS in 11 PD patients. Only patients that demonstrated a temporary persistence of clinical benefit after cessation of HFS were analyzed. STN HFS led to a significant reduction in STN LFP ␤ activity for 12 s after the end of stimulation and a decrease in motor cortical-STN coherence in the ␤ band over the same time period. The reduction in LFP ␤ activity correlated with the movement amplitude during a simple motor task, so that a smaller amount of ␤ activity was associated with better task performance. These features were absent when power in the 5-12 Hz frequency band was considered. Our findings suggest that HFS may act by modulating pathological patterns of synchronized oscillations, specifically by reduction of pathological ␤ activity in PD.

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“…Recientemente se ha demostrado que el parkinsonismo está relacionado a una hiperactividad del NST con hipersincronización de las oscilaciones de baja frecuencia entre el NST y el Globo Pálido (GP), lo que de alguna forma interfi ere con la capacidad de iniciar o detener programas motores en la corteza [14][15][16][17][18][19] . También se ha sugerido que el parkinsonismo puede relacionarse a cambios neuroplásticos de la vía directa como consecuencia de la denervación dopaminérgica, sobre todo a nivel del estriado y en los núcleos de salida de los GB (SNpr/GPi).…”

Section: A Enfermedad De Parkinson Idiopática (Epi) Esunclassified

“…En algunos estudios a través de la utilización de potenciales de campo local se ha encontrado en paciente con EPI la presencia de actividad sincrónica oscilatoria en el NST evocada por le estimulación cortical. Esta actividad es de alta frecuencia en el rango de frecuencia beta y la misma propicia la presencia de actividad oscilatoria sincrónica en los ganglios basales lo que contribuye a la aparición del cortejo sintomático de la enfermedad 14,16,18,48 .…”

Section: A Enfermedad De Parkinson Idiopática (Epi) Esunclassified

El núcleo subtalámico en la fisiopatología de la enfermedad de Parkinson y su rol como diana quirúrgica

Méndez-Herrera

2011

Rev. chil. neuro-psiquiatr.

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The relationship between local field potential and neuronal discharge in the subthalamic nucleus of patients with Parkinson's disease

Cited by 358 publications

References 27 publications

Beta Reactivity, Prospective Facilitation of Executive Processing, and Its Dependence on Dopaminergic Therapy in Parkinson's Disease

Beta Reactivity, Prospective Facilitation of Executive Processing, and Its Dependence on Dopaminergic Therapy in Parkinson's Disease

High-Frequency Stimulation of the Subthalamic Nucleus Suppresses Oscillatory Activity in Patients with Parkinson's Disease in Parallel with Improvement in Motor Performance

El núcleo subtalámico en la fisiopatología de la enfermedad de Parkinson y su rol como diana quirúrgica

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