The relationship between lipoprotein(a) and coronary artery disease, as well as its variable nature following myocardial infarction

Abstract

Turkeye relationship between lipoprotein(a) and coronary artery disease, as well as its variable nature following myocardial infarction AbstractPurpose: e present study aimed to investigate the relationship between the severity of coronary artery disease (CAD) and level of Lipoprotein (LP)(a).Methods: e study included 52 CAD patients and a control group consisting of 38 individuals. e patients were classi ed into three groups based on the clinical form of CAD (stable angina pectoris, SAP, unstable angina pectoris,UAP, and myocardial infarction,MI), and were further divided into three groups based on CAD severity (1-, 2-and 3-vessel). Serum Lp(a) levels were monitored 4, 8, and 24 h, 10 and 30 days following acute MI in 18 patients.Results: Based on regression analysis, Lp(a) was not correlated with other lipoproteins or with risk factors of CAD, such as body mass index, smoking, family history, diabetes, age, gender, and hypertension (r = 0.08-0.22). 72% of the patients in the CAD group and 24% of the control group had an Lp(a) level >30 mg dL -1 (P = 0.004), and Lp(a) levels were higher in 3-vessel patients than in 2-vessel and 1-vessel CAD patients (86% vs. 68%, P = 0.02 and 86% vs. 62%, P=0.01, respectively). Serum Lp(a) levels were higher in the UAP and MI groups than in the SAP group (48 ± 44.7 mg dL -1 , 49 ± 36.1 mg dL -1 and 31.2 ± 22.3 mg dL -1 , respectively,P=0.02). Lp(a) levels increased a er acute MI, and reached peak levels 10 days post-MI (41% increase, P=0.001) and remained considerably elevated (18%) 30 days post-MI (P=0.01).Conclusion: Serum Lp(a) was higher in the UAP and MI patients in comparison with the SAP patients, and was higher in 3-vessel CAD in comparison with 1-and 2-vessel CAD patients.

Correlation of Lipoprotein (a) Level with Complexity of Coronary Lesion in Coronary Heart Disease Patient at RSUP Dr. Sardjito Yogyakarta

“…Another interesting thing is the level of Lp (a) also reflects the degree of severity and is associated with the number of coronary arteries that terlibat 7,8,9 . Other studies have also shown consistent results in which the levels of Lp (a) in patients with three vessels disease two times higher than patients with one or two blood vessels involved 2,10,11,12 . Research also shows that levels of Lp (a) increases in patients with acute coronary syndrome and higher in patients with significant coronary lesions (≥ 50%) but had a weak correlation (r = 0.106) with the degree of severity of lesion 13 .…”

Health Behaviors and Clinical Outcomes Among Patients with Myocardial Infarction in Indonesia

“…The findings are in agreement with those of which Gaziano et al (2010) Ahyana et al (2014), who noted health behavior related with the age, and marital status. However, compared to the study of Ornek et al (2011) (Gaziano et al, 2010). A history of prior smoking was more strongly associated with MI in men compared to that in women (Anand et al, 2008), also it was reported that a woman controls smoking easier than a man (NHLBI, 2014 (Damman et al, 2013).…”

“…Total cholesterol was positively associated with ischemic heart disease mortality at all blood pressure levels (Zodpey, Shrikhande, Negandhi, Ughade, & Joshi, 2015). Moreover, high cholesterol levels are estimated to cause 56% of ischemic heart disease Worldwide (Gaziano et al, 2010 (Ornek et al, 2011).…”

Serum lipoprotein(a) concentrations do not change significantly in the immediate seven-day period post myocardial infarction

“…5 The wide range of Lp(a) in this study may be due to the varying severity of MI, as it has been shown to correlate with the size of the necrotic area. 6,7 Due to the limitation of available clinical details, this correlation could not be analysed in this study.…”