The relationship between leukemoid reaction and perinatal morbidity, mortality, and chorioamnionitis in low birth weight infants

Duran, Rıdvan; Özbek, Ülfet Vatansever; Çiftdemir, Nükhet Aladağ; Acunaş, Betül; Süt, Necdet

doi:10.1016/j.ijid.2010.06.012

Cited by 22 publications

(19 citation statements)

References 16 publications

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“…Other mechanisms, such as a neonatal leukemoid reaction induced by CA, have also been suggested as important risk factor for BDP. 94,95 In contrast to HCA, Alexander et al reported an increased incidence of RDS among preterm babies exposed to CCA. Of note, many of these studies were conducted prior to the widespread use of prenatal corticosteroids for fetal lung maturation, exogenous surfactant administration, and/or noninvasive ventilation, which are currently considered standard practices with proven benefit for patients and improved respiratory outcomes.…”

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confidence: 99%

Chorioamnionitis and neonatal morbidity: current perspectives

Henríquez¹,

Rodrigo²

2017

RRN

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Abstract:The term chorioamnionitis (CA) is commonly used to refer to different clinical or pathological conditions characterized by an infectious and/or inflammatory process that affects primarily the chorioamniotic membranes, but also the amniotic fluid, vessels of the chorionic plate, and, eventually, the umbilical cord (funisitis) and the fetus. Its incidence is higher at lower gestational ages, and the main mechanism is believed to be the ascending bacterial infection from the maternal genital tract. It can be diagnosed by clinical criteria, amniotic fluid examination for inflammatory mediators, and/or isolation of microorganisms, or by histopathological examination of the placenta. CA is an important cause of stillbirth and is related to an increased incidence of premature rupture of membranes, preterm delivery, and adverse maternal and neonatal outcomes such as early-onset neonatal sepsis and necrotizing enterocolitis. An independent causal association to other neonatal morbidities is more controversial. The heterogeneity in the diagnostic criteria and in the operative definitions for morbidity makes comparison of studies difficult, and results are inconsistent. In addition, the intensity and duration of the process are usually not considered. For all these reasons, evidence-based recommendations for the management of mother and infant under these circumstances are difficult to establish, and clinical practice varies widely.

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confidence: 99%

Chorioamnionitis and neonatal morbidity: current perspectives

Henríquez¹,

Rodrigo²

2017

RRN

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“…Although the exact causative mechanism is still unclear, several hypotheses are documented in the literature, of which chorioamnionitis, 2,8,9 perinatal infection, 6,10,11 and the administration of ACS 12-14 seem to be the most important triggers.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4][5][6] It is defined as a state in which the white blood cell count is Z50 Â10 9 /L or the absolute neutrophil count is Z30 Â10 9 /L during the neonatal period. 7 In this case report, we describe 2 dichorionic diamniotic premature twins, of whom the 2 girls had an extreme hyperleukocytosis, whereas their siblings did not.…”

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confidence: 99%

Discordant Transient Extreme Hyperleukocytosis in Dichorionic Diamniotic Twins

Boesveld

Hemels²

2016

Journal of Pediatric Hematology/Oncology

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Although a leukemoid reaction is a well-recognized phenomenon in the neonatal intensive care unit, transient extreme hyperleukocytosis in premature infants is rare. The exact mechanism is still unclear and several hypotheses are documented in the literature. In this case report, we describe 2 dichorionic diamniotic premature twins, of whom the 2 girls had extreme hyperleukocytosis, whereas their siblings did not, emphasizing the potentially important role of the sex in this phenomena.

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“…Neonates with leukemoid reaction had a 4-fold increase in sepsis, 20-fold increase in intraventricular hemorrhage, 54-fold increase in bronchopulmonary dysplasia and 6-fold increase in mortality compared with controls. 16 The decision to proceed with double volume exchange transfusion in this patient was based on concerns of high blood viscosity contributing to the risk of neurological injury. This baby was at considerable risk of a poor neurodevelopmental outcome because of prematurity, low 10 min Apgar score and the prominent vesicular rash at birth.…”

Section: Discussionmentioning

confidence: 99%