The Relationship between Leptin and Fatty Acid

Sarı, Aysel

doi:10.4172/2155-9929.1000139

Cited by 6 publications

(3 citation statements)

References 47 publications

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“…Fatty acid composition was influenced by LEP genotype: L goats, compared to H goats, showed higher levels of 4:0, 17i so , 18:0, 18:1 c 9, 18:1 c 11, 20:4 n-3, MUFA, and PUFA, and lower levels of 16:0 and SFA. It has been shown that leptin has a strong influence on fatty acids metabolism [31]. The analyzed polymorphism does not seem to be causative of the observed differences that could therefore be explained by the association of polymorphism with a quantitative trait loci (QTL) that influences milk fatty acids composition.…”

Section: Discussionmentioning

confidence: 99%

Leptin Gene Polymorphism in Goats Fed with Diet at Different Energy Level: Effects on Feed Intake, Milk Traits, Milk Fatty Acids Composition, and Metabolic State

Avondo

Trana

Valenti

et al. 2019

Animals

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The study investigated the effects of a polymorphism at the LEP gene intron 1 microsatellite region and its interaction with diet energy level on feed intake, milk traits, milk fatty acid composition, and metabolic state in goats. Sixteen Girgentana lactating goats at mid-lactation, selected on the basis of their genotype (8 goats homozygous 266 bp/266 bp, L genotype; 8 goats heterozygous 266 bp/264 bp, H genotype), were fed ad libitum according to a change-over design, with two diets at different energy levels reached with different hay inclusion: low energy diet (LE)—100% of hay; and high energy diet (HE)—65% of hay. No differences in milk yield and composition or in dry matter intake were found between leptin genotypes or between diets. Leptin genotype had no effect on plasma metabolite concentrations. The differences between diets were recorded for plasma β-hydroxybutyric acid (BHBA) concentrations with higher (p = 0.01) values for the HE compared to the LE diet (0.44 vs. 0.24 mmol/L, respectively). Nonesterified fatty acid (NEFA) values seem to indicate a positive energy balance in goats. No interaction genotype per diet was evident for most of the studied parameters. Fatty acid composition was strongly influenced by LEP genotype: L goats, compared to H goats, showed higher levels of monounsaturated fatty acids (MUFA), polyunsaturated fatty acids (PUFA), and 14:1/14:0 desaturation index; lower levels of saturated fatty acids (SFA); and a more favorable atherogenic index. These results seem to suggest an improvement of health characteristics of milk with the L genotype.

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Section: Discussionmentioning

confidence: 99%

Leptin Gene Polymorphism in Goats Fed with Diet at Different Energy Level: Effects on Feed Intake, Milk Traits, Milk Fatty Acids Composition, and Metabolic State

Avondo

Trana

Valenti

et al. 2019

Animals

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“…We can say that the decrease of leptin secretion is related to the increase of lipolysis, because leptin is secreted from adipocyte. It was shown that leptin levels are tightly correlated with the total amount of white fat in the body [ 37 ]. It was also observed that curcumin inhibited adipocyte differentiation in 3T3-L1 adipocytes by intracellular lipid accumulation assay [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

KoreanCurcuma longa L. induces lipolysis and regulates leptin in adipocyte cells and rats

Song

Choi

2016

Nutr Res Pract

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BACKGROUND/OBJECTIVESTurmeric (Curcuma longa L.) has been reported to have many biological functions including anti-obesity. Leptin, peptide hormone produced by adipocytes and its concentration is increased in proportion to the amount of the adipocytes. In the present study, we examined the effects of Korean turmeric on the regulation of adiposity and leptin levels in 3T3-L1 adipocytes and rats fed a high-fat and high-cholesterol diet.MATERIALS/METHODSLeptin secretion, free fatty acid and glycerol contents in 3T3-L1 adipocytes were measured after incubation of cells with turmeric for 24 hours. Rats were divided into four experimental groups: a normal diet group (N), a high-fat and high-cholesterol diet group (HF), a high-fat and high-cholesterol diet group supplemented with 2.5% turmeric extracts (TPA group) and a high-fat and high-cholesterol diet group supplemented with 5% turmeric extracts (TPB group). Serum samples were used for the measurement of leptin concentration.RESULTSContents of free fatty acid and glycerol showed concentration dependent increase in response to turmeric extracts. Effects of turmeric extracts on reduction of lipid accumulation in 3T3-L1 cells were examined by Oil Red O staining. Treatment with turmeric extracts resulted in increased expression levels of adipose triglyceride lipase and hormone-sensitive lipase mRNA. The concentration of leptin from 3T3-L1 adipocytes was significantly decreased by turmeric. Proportional abdominal and epididymal fats weights of the turmeric 5% supplemented group, TPB has significantly decreased compared to the HF group. The serum levels of leptin in the TPA and TPB groups were significantly lower than those of the HF group.CONCLUSIONSBased on these results, we suggested that Korean turmeric may contribute to the decreasing of body fat and regulating leptin secretion.

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“…Adipocyte body weight regulation is the fact that a decrease in starvation adiposity causes hyperphagia, reduces the amount of energy, and eventually returns body weight back to the previous level [3 and 4]. This hormone also has effects on fatty acid (FA), and was found to cause an increase in the oxidation capacity to FA and a decrease in triacylglycerol stores [5]. The energy balance created by this hormone is seen in glucose and lipid metabolism, reproduction, cardiovascular function, and immunity.…”

Section: Introductionmentioning

confidence: 99%

The Relationship the Leptin Hormone, Obesity and Diabetes

Sarı¹,

Sadeq²

2020

NWSA

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Leptin, which is adipocytes, secreted of the hormone, over food intake regulation, energy expenditure has also an important role in acting as neuroendocrine hormone, and metabolic function.it is interested in glucose metabolism and interacts with insulin metabolism. In addition to distrusting metabolism, leptin also impairs endocrine, immune functions, reproductive function, adipose tissue metabolism and energy order. Leptin also exerts peripheral effects directly on glucose metabolism and gluconeogenesis. it is obvious that leptin deficiency or leptin resistance is responsible for obesity which is also correlated with body fat stores, here we have to refer that is the obesity is one of the most causes of diabetes also it leads to insulin resistance. In these studies, we will focus on the relationship between leptin and diabetes mellitus type 2 and insulin resistance with obesity. In this study, we will focus on the relationship between the leptin hormone and obesity with diabetes.

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The Relationship between Leptin and Fatty Acid

Cited by 6 publications

References 47 publications

Leptin Gene Polymorphism in Goats Fed with Diet at Different Energy Level: Effects on Feed Intake, Milk Traits, Milk Fatty Acids Composition, and Metabolic State

Leptin Gene Polymorphism in Goats Fed with Diet at Different Energy Level: Effects on Feed Intake, Milk Traits, Milk Fatty Acids Composition, and Metabolic State

KoreanCurcuma longa L. induces lipolysis and regulates leptin in adipocyte cells and rats

The Relationship the Leptin Hormone, Obesity and Diabetes

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