The Relationship between Ischemia Modified Albumin and Oxidative Stress Parameters in Patients with Cardiac Syndrome X

Demir, Bülent; Özyazgan, Sibel; Korkmaz, Gülcan Güntaş; Karakaya, Osman; Açıksarı, Gönül; Uygun, Turgut; Önal, Burak; Uzun, Hafize

doi:10.7754/clin.lab.2013.121142

Cited by 5 publications

(4 citation statements)

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“…However, to our knowledge, there is no information about plasma levels of AOPP in combination with IMA and SH groups in terms of their connection with risk factors of occurrence of MetS. Only a single investigation by Demir et al [32] has determined simultaneously AOPP and IMA levels, but in patients with cardiac syndrome X. The authors found an increase in OS (expressed as increased values of PAB, AOPP and IMA) and a positive correlation between AOPP and IMA in these patients.…”

Section: Discussionmentioning

confidence: 99%

Oxidatively modified forms of albumin in patients with risk factors of metabolic syndrome

Żurawska-Płaksej

Grzebyk

Marciniak

et al. 2014

J Endocrinol Invest

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BackgroundMetabolic syndrome (MetS) is a complex metabolic disease connected especially with lipid and carbohydrate disturbances. It is postulated that oxidative stress (OS) is linked to metabolic syndrome, constituting a novel component of its pathogenesis.AimWe aimed to examine the plasma level of oxidatively modified proteins––advanced oxidation protein products (AOPP) and ischemia modified albumin (IMA)––as well as thiol (SH) groups and evaluate their connection with metabolic agents in relation to MetS prevalence.Subjects and methodsThe levels of AOPP, IMA and SH groups were measured spectrophotometrically in 106 patients with MetS risk factors and in 32 control subjects.ResultsThe levels of examined parameters differed significantly between patients with MetS risk factors and the control group. AOPP significantly correlated with glucose (r = 0.30, p = 0.008), HDL-Ch (r = −0.34, p = 0.005), TG (r = 0.48, p < 0.001) and fibrinogen (r = 0.37, p < 0.001). The levels of AOPP and IMA increased progressively with the number of MetS risk factors, being the most significant for AOPP. The highest values of AOPP were associated with the presence of at least three risk factors. Only AOPP were an independent determinant for MetS occurrence in the studied population (OR = 2.72, p = 0.04). Mutual dependence between metabolic, oxidative stress and inflammatory parameters was revealed.ConclusionsOxidative modifications of proteins are increased in MetS and accumulation of MetS risk factors enhances manifestation of OS. AOPP is the most appropriate parameter for determination of OS, with potential diagnostic value in MetS patients.

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Section: Discussionmentioning

confidence: 99%

Oxidatively modified forms of albumin in patients with risk factors of metabolic syndrome

Żurawska-Płaksej

Grzebyk

Marciniak

et al. 2014

J Endocrinol Invest

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“…In ischemic conditions, the form of the N-terminus changes, and the metal-binding capacity decreases. Thus, this new form is called ischemia-modified albumin (IMA), a novel ischemia marker [4–6]. In recent years, elevated levels of IMA are thought to be associated with several diseases based on oxidative stress [5–7].…”

Section: Introductionmentioning

confidence: 99%

The correlation between the psoriasis area severity index and ischemia-modified albumin, mean platelet volume levels in patients with psoriasis

Işık¹,

Kılıç²,

Öğretmen³

et al. 2016

pdia

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IntroductionIschemia-modified albumin (IMA), a novel ischemia marker, and mean platelet volume (MPV), a determinant of platelet activation, have been reported as elevated markers in cardiovascular risk factors such as atherosclerosis, metabolic syndrome, diabetes mellitus (DM), hypertension, and dyslipidemia. As psoriasis is a chronic inflammatory disease having comorbidities, IMA and MPV can help determine the risk factors for psoriasis.AimTo investigate the correlation between the psoriasis area severity index (PASI), IMA and MPV levels in patients with psoriasis.Material and methodsThis cross-sectional, case-control study was performed between January 2014 and December 2014 at the University hospital in Çanakkale, Turkey. Forty-five patients with psoriasis and 44 healthy volunteers over 18 years of age were included in the study. In the psoriasis patient group, clinical features and PASI scores were recorded. Serum IMA and MPV concentrations were evaluated in both groups.ResultsThe mean IMA values were 0.85 ±0.15 and 0.79 ±0.09 (in the psoriasis patients and control groups, respectively), and there was a statistically significant difference (p = 0.048). Ischemia-modified albumin levels were not correlated with PASI scores (r = 0.024; p = 0.889) but were correlated with disease duration (r = 0.323; p = 0.048). There was no statistically significant difference between the MPV values of the two groups (8.98 ±1.14 and 9.19 ±1.28 in the psoriasis patients and control groups, respectively) (p = 0.435).ConclusionsIschemia-modified albumin may be used as a marker for detecting oxidative stress in patients with psoriasis, especially those with a long disease duration.

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“…In our study, both AOPP and IMA were increased progressively in all the groups containing increasing number of risk factors of CVD compared to control group. Subjects with more components of MetS may have a higher oxidative stress level [20]. Therefore, it is suggested that protein modification by oxidative stress is increased with increase in number of risk factors of CVD.…”

Section: Discussionmentioning

confidence: 99%

“…These findings are consistent with the study conducted by YuberoSerrano etal. [20] It has been postulated that increased triglycerides directly takes part in atherogenesis by increasing oxidative stress like in hyperglycemia. [21][21] [22] In addition, mild inflammation and visceral cytokine production are also responsible for development of CVD in patients with increased WC.…”

Section: Discussionmentioning

confidence: 99%

A study of levels of oxidative protein modification markers AOPP and IMA with risk factors of metabolic syndrome

K¹,

Uthappa²,

Surendran

et al. 2015

Int Jour of Biomed Res

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Objective: the study was designed to look in if there was any role for protein oxidation markers [like Advanced Oxidation Protein Products (AOPP) and Ischemia Modified Albumin (IMA)] in the pathogenesis of metabolic syndrome (MetS) and effect of number of risk factors of MetS on the level of these protein oxidation markers. Method:A total of 165 (n) patients were included in the study. Patients were divided into four groups based on presence or absence of 5 cardiovascular risk factors specified in revised NCEP (rNCEP) definition for MetS. Comparisons of the examined groups were statistically analysed by the application of Student's t test. Analysis of variance (ANOVA) followed by multiple comparison post hoc Fisher test were used for the analysis of differences between the groups with different numbers of risk factors of MetS. Results: Both AOPP and IMA values significantly correlated with waist circumference, glucose, HDL-Ch and TG (p value < 0.05). AOPP and IMA values between control group and the rest of the groups showed significant difference (p value <0.05). Systolic BP however, did not show significant association with AOPP as well as with IMA (p values 0.139 and 0.083 respectively).

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The Relationship between Ischemia Modified Albumin and Oxidative Stress Parameters in Patients with Cardiac Syndrome X

Cited by 5 publications

References 0 publications

Oxidatively modified forms of albumin in patients with risk factors of metabolic syndrome

Oxidatively modified forms of albumin in patients with risk factors of metabolic syndrome

The correlation between the psoriasis area severity index and ischemia-modified albumin, mean platelet volume levels in patients with psoriasis

A study of levels of oxidative protein modification markers AOPP and IMA with risk factors of metabolic syndrome

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