The relationship between in vitro fertilization and naturally occurring antibodies: evidence for increased production of antiphospholipid autoantibodies

Thrombophilia and outcomes of assisted reproduction technologies: a systematic review and meta-analysis

“…Some authors have suggested that levels of anti-phospholipid antibodies may increase during IVF cycles, 29 although this has not been confirmed by others. 51 The time of blood withdrawing for antibody measurement was reported in only half of the studies; and in 41% of cases, it appeared performed away from the hormonal stimulation. Finally, but not lastly, anti-phospholipid antibodies were not associated with ART failure in cohort studies, which could, however, depend on a type II error.…”

The role of free radicals and antioxidants in reproduction

“…Indirect evidence of oxidative stress has been associated with antiphospholipid generation during IVF. Presence of antiphospholipid antibodies in the plasma, and its association with increased oxidative stress in the plasma, was reported in infertility patients undergoing IVF [48][49][50]. In a pilot study isoprostane 8,12-iso-iPGF2α was detected in sera as a marker of oxidative stress in patients undergoing IVF [47].…”

Anti-phospholipid antibodies do not affect IVF success

“…Of these, three included only treated subjects (2,4,5), three lacked cohorts of IVF couples (6)(7)(8), two commentaries included no original data (1,9), and one included no IVF outcome data (10). From the remaining seven studies, we abstracted data on the patients with and without APA who underwent IVF therapy and did not receive APA-related therapy (3,(11)(12)(13)(14)(15)(16).…”