2011
DOI: 10.1182/blood-2011-03-340216
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Thrombophilia and outcomes of assisted reproduction technologies: a systematic review and meta-analysis

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Cited by 82 publications
(61 citation statements)
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“…While some studies have suggested that repeat IVF failure may be associated with an increased incidence of thrombophilia [37][38][39][40][41] others have negated such an association [42][43][44]. In a recent systemic review and metaanalysis, pooled data from patients in 8 case control studies showed an overall 3-fold increased risk of ART failure in association with factor V Leiden; while in the 3 cohort studies there was no difference in outcome between those with and those without factor V Leiden mutation [45]. Although our study was not targeted to examine the association between thrombophilia and repeat IVF failure, our findings do not support such an association.…”
Section: Discussionmentioning
confidence: 99%
“…While some studies have suggested that repeat IVF failure may be associated with an increased incidence of thrombophilia [37][38][39][40][41] others have negated such an association [42][43][44]. In a recent systemic review and metaanalysis, pooled data from patients in 8 case control studies showed an overall 3-fold increased risk of ART failure in association with factor V Leiden; while in the 3 cohort studies there was no difference in outcome between those with and those without factor V Leiden mutation [45]. Although our study was not targeted to examine the association between thrombophilia and repeat IVF failure, our findings do not support such an association.…”
Section: Discussionmentioning
confidence: 99%
“…No significant differences were found in relation to other thrombophilia mutations. The results of this review were inconclusive, since the methodological quality of studies was poor, many were retrospective case-control, known to be limited by poor collection of data D. Khalife, G. Ghazeeri Open Journal of Obstetrics and Gynecology on potential confounders and recall bias [49]. Ricci has confirmed the absence of association of thrombophilia with adverse IVF outcome by conducting a prospective cohort study of 510 women to compare the prevalence of factor V leiden and prothrombin gene G20210A mutation in women undergoing IVF and showed no statistical significant difference in the reproductive outcomes (implantation rate (IR), clinical pregnancy rate (CPR), and livebirth rate (LBR)) compared to non-mutation carrier women [43].…”
Section: Thrombophilia and Ivfmentioning
confidence: 91%
“…Although the relationship between vascular thrombosis and obstetric complications was first recognized in women with Antiphospholipid Syndrome (APS), both inherited and acquired thrombophilia have been associated with recurrent pregnancy loss and pregnancy complications, such as severe pre-eclampsia, fetal growth restriction and stillbirth [41].…”
Section: Thrombosis and Rmmentioning
confidence: 99%
“…However, it is noteworthy that women with the presence of aPL and no evidence of placental thrombosis also experience pregnancy loss [41,54]. Thus, pathophysiology other than placental thrombosis may influence pregnancy outcome.…”
Section: Acquired Thrombophilic Conditionsmentioning
confidence: 99%