The Relationship Between IL-1 Gene Polymorphism and Marginal Bone Loss Around Dental Implants

Biological Factors Involved in Implant-Anchored Orthodontics and in Prosthetic-Implant Therapy: A Literature Review

“…Furthermore, the authors found that the IL-1B-511 gene could serve as a genetic marker associated with non-infectious loss of the alveolar bone before connection of the abutments. Similar conclusions were drawn by Lin et al (2007). They examined the polymorphisms of IL-1 genes in 59 patients (mean age 42.77 years) with 143 dental implants.…”

“…Lachmann et al (2007) found that composite genotype (IL-1A-889 and IL-1B?3954) had only a small influence on the immune response, but they suggested that the methodology used could have affected the results. In contrast, Shimpuku et al (2003) and Lin et al (2007) reported a relationship between polymorphisms of the IL-1 gene and marginal bone loss around dental implants. Shimpuku et al (2003) performed a case-control studythe material consisted of 39 Japanese patients (mean age 55.1 ± 9.4 years) who underwent implantation in the maxilla and/or mandible.…”

“…Some studies concentrated on the issue of the relationship between this gene polymorphism and risk factors for dental implant failure (Lachmann et al 2007;Lin et al 2007;Rogers et al 2002;Shimpuku et al 2003). Rogers et al (2002) observed no association between IL-1A-889 and IL-1B?3953 alleles or the composite genotype and the failure of dental implants.…”

Peri-implant Diseases

“…[74][75][76] However, in a systematic review, Dereka and colleagues 77 reported no apparent association between specific genetic polymorphism and dental implant failure in terms of biological complications (peri-implant diseases). Hultin and colleagues, 78 Rogers and colleagues, 79 and Campos and colleagues 80 also reported no association between gene polymorphism and peri-implantitis.…”

The Current Knowledge of Genetic Susceptibility Influencing Dental Implant Outcomes

“…The association of IL1A gene (which codes for IL-1 ) polymorphisms with dental implant outcome was investigated in several studies (Campos et al, 2005c;Feloutzis et al, 2003;Gruica et al, 2004;Jansson et al, 2005;Lachmann et al, 2007;Laine et al, 2006;Lin et al, 2007;Rogers et al, 2002;Shimpuku et al, 2003b;Wilson and Nunn, 1999). Since IL1B gene (which codes for IL-1 ) was seen to be upregulated at early stages of healing and then down-regulated at later stages (Lin et al, 2010), polymorphisms in IL1B gene were also investigated for association with implant failure susceptibility (Campos et al, 2005b;Dirschnabel et al, 2011;Feloutzis et al, 2003;Gruica et al, 2004;Jansson et al, 2005;Lachmann et al, 2007;Laine et al, 2006;Lin et al, 2007;Melo et al, 2011;Montes et al, 2009;Rogers et al, 2002;Shimpuku et al, 2003b;Wilson and Nunn, 1999). Moreover, IL1RN gene (which codes for IL-1ra) was also searched for association to implant failure (Campos et al, 2005c;Laine et al, 2006;Montes et al, 2009).…”