The relationship between hepatitis C virus infection and diabetes: Time for a divorce?

Cusi, Kenneth

doi:10.1002/hep.27252

Cited by 14 publications

(13 citation statements)

References 24 publications

(48 reference statements)

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“…However, in line with several other studies [44,45] holding the opposite standpoint, a very recent study by Ruhl et al [46], using the clinical data of a well-established population-based cohort of 15,128 adults in the USA, demonstrates that there may not exist a significant association between HCV infection and diabetes or even IR. The underlying reason for this obvious divergence might be the disturbance of the severity of liver disease in the subjects of different cohorts [47]. Nevertheless, compared with the conditions of HCV infection, there are even more uncertainties regarding the pathogenic correlation between the HBV infection and NAFLD.…”

Section: Mechanistic Interactions Between Nafld and Hbv Infectionmentioning

confidence: 98%

Interactions of Hepatitis B Virus Infection with Nonalcoholic Fatty Liver Disease: Possible Mechanisms and Clinical Impact

et al. 2015

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Hepatitis B virus (HBV) infection is a major etiology of chronic liver disease worldwide. In the past decade, nonalcoholic fatty liver disease (NAFLD) has emerged as a common liver disorder in general population. Accordingly, the patient number of chronic hepatitis B (CHB) concomitant with NAFLD grows rapidly. The present article reviewed the recent studies aiming to explore the relationship between CHB and NAFLD from different aspects, including the relevant pathogenesis of CHB and NAFLD, the intracellular molecular mechanisms overlaying HBV infection and hepatic steatosis, and the observational studies with animal models and clinical cohorts for analyzing the coincidence of the two diseases. It is concluded that although numerous cross-links have been suggested between the molecular pathways in HBV infection and NAFLD pathogenesis, regarding whether HBV infection can substantially interfere with the occurrence of NAFLD or vice versa in the patients, there is still far from a conclusive agreement.

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Section: Mechanistic Interactions Between Nafld and Hbv Infectionmentioning

confidence: 98%

Interactions of Hepatitis B Virus Infection with Nonalcoholic Fatty Liver Disease: Possible Mechanisms and Clinical Impact

et al. 2015

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“…The study highlighted the importance of adequately controlling for elevated liver enzymes in studies of the relationship of HCV with DM. They suggest that the HCV‐infected population might also have higher rates of nonalcoholic steatohepatitis, a condition which has been shown to be associated with insulin resistance or diabetes …”

mentioning

confidence: 99%

Chronic hepatitis C virus infection and the risk for diabetes: a community‐based prospective study

Lin

Shaw

Yang

et al. 2016

Liver International

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“…11,12 Although some studies have found that T2D occurs more frequently among subsets of HCVinfected versus uninfected individuals, [13][14][15] other studies suggest that observed increases in the risk of T2D may be a consequence of HCV-related elevation in ALT, 16,17 perhaps further confounded by high BMI and/or cirrhosis. 18 We found that cirrhosis, but not baseline ALT, independently increased the risk of T2D in all treatment groups. Although we observed that successful HCV treatment reduced the risk of future diabetes, our analysis could not evaluate whether this risk reduction resulted from viral eradication, from subsequent reductions in inflammation or fibrosis, or through some other mechanism.…”

Section: Discussionmentioning

confidence: 59%

Impact of sustained virologic response on risk of type 2 diabetes among hepatitis C patients in the United States

Zhang

Gordon

et al. 2018

Journal of Viral Hepatitis

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Data regarding the impact of hepatitis C (HCV) therapy on incidence of type 2 diabetes mellitus are limited. We used the data from the longitudinal Chronic Hepatitis Cohort Study-drawn from four large US health systems-to investigate how response to HCV treatment impacts the risk of subsequent diabetes. Among HCV patients without a history of type 2 diabetes mellitus or hepatitis B, we investigated the incidence of type 2 diabetes from 12 weeks post-HCV treatment through December 2015. Cox proportional hazards models were used to test the effect of treatment status (sustained virologic response [SVR] or treatment failure) and baseline risk factors on the development of diabetes, considering any possible risk factor-by-SVR interactions, and death as a competing risk. Among 5127 patients with an average follow-up of 3.7 years, diabetes incidence was significantly lower among patients who achieved SVR (231/3748; 6.2%) than among patients with treatment failure (299/1379; 21.7%; adjusted hazard ratio [aHR] = 0.79; 95% CI: 0.65-0.96). Risk of diabetes was higher among African American and Asian American patients than White patients (aHR = 1.82 and 1.75, respectively; P < .05), and among Hispanic patients than non-Hispanics (aHR = 1.86). Patients with BMI ≥ 30 and 25-30 (demonstrated higher risk of diabetes aHR = 3.62 and 1.72, respectively; P < .05) than those with BMI < 25; patients with cirrhosis at baseline had higher risk than those without cirrhosis (aHR = 1.47). Among a large US cohort of patients treated for HCV, patients who achieved SVR demonstrated a substantially lower risk for the development of type 2 diabetes mellitus than patients with treatment failure.

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The relationship between hepatitis C virus infection and diabetes: Time for a divorce?

Cited by 14 publications

References 24 publications

Interactions of Hepatitis B Virus Infection with Nonalcoholic Fatty Liver Disease: Possible Mechanisms and Clinical Impact

Interactions of Hepatitis B Virus Infection with Nonalcoholic Fatty Liver Disease: Possible Mechanisms and Clinical Impact

Chronic hepatitis C virus infection and the risk for diabetes: a community‐based prospective study

Impact of sustained virologic response on risk of type 2 diabetes among hepatitis C patients in the United States

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