The relationship between Helicobacter pylori IgG titre and coronary atherosclerosis

Özdoğru, İbrahіm; Kalay, Nihat; Doğan, Ali; İnanç, Mehmet Tuğrul; Kaya, Mehmet; Topsakal, Ramazan; Gül, İbrahim; Kutukoglu, Ilker; Kılıç, Hüseyin; Eryol, Namık Kemal

doi:10.2143/ac.62.5.2023414

Cited by 30 publications

(26 citation statements)

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“…Some trials demonstrated that HP infection may have a role in the development of atherosclerosis and may be a risk factor for CAD but some did not [5][6][7][8][9]. In the present study, we confirmed the presence of a significant association between HP infection and angiographically confirmed CAD.…”

Section: Discussionsupporting

confidence: 85%

Helicobacter pylori Seropositivity in Patients with Acute Coronary Syndromes

et al. 2008

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The aim of this study was to investigate the seroprevalence of Helicobacter pylori (HP) in patients with coronary atherosclerosis and acute coronary syndromes. We enrolled 152 patients (group I, 73 patients with acute coronary syndrome; group II, 79 patients with chronic stable angina) and 22 control subjects. An enzyme-linked immunosorbent assay for immunoglobulin (Ig) G test for HP diagnosis was used on all enrolled subjects. C-reactive protein (CRP) was also measured in all patients as an inflammatory marker. Seropositivity rates for HP were significantly higher in patients with coronary artery disease than in controls (80.2% versus 54.5%; P < 0.05). Although CRP level was significantly higher in group I than in group II (1.72 +/- 2.89 mg/dl versus 0.53 +/- 0.63 mg/dl, P < 0.0001), HP infection rates were similar between groups (86.3% versus 74.6%, P > 0.05). Infection with HP may influence atherogenesis through low-grade, persistent inflammatory stimulation. However, our data show evidence of increased systemic inflammation in patients with acute coronary syndrome, which was unrelated to an increased HP seropositivity.

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Section: Discussionsupporting

confidence: 85%

Helicobacter pylori Seropositivity in Patients with Acute Coronary Syndromes

et al. 2008

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“…This study also revealed a reverse correlation between FMD changes and the serum level of IgG as a serological marker of H. pylori infection, for the first time. In a study by Ozdogru and colleagues, the relationship between IgG titer and the extent of coronary artery disease was reported among patients with angiography proven coronary artery disease (CAD) as well as those with acute coronary syndrome (ACS) (14) , while Hara and colleagues have rejected this kind of association (6) . This study showed a direct association between CIMT and IgG titer in chronic gastritis associated with H. pylori infection compared to the healthy subjects and furthermore compared to patients with negative H. pylori infection.…”

Section: Relationship Between Igg Level With Markers Of Endothelial Dmentioning

confidence: 99%

Flow Mediated Dilation and Carotid Intima Media Thickness in Patients With Chronic Gastritis Associated With Helicobacter Pylori Infection

Judaki

Norozi

Ahmadi

et al. 2017

Arq. Gastroenterol.

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“…These results support the idea that past or chronic exposure to H. pylori infection, perhaps as a result of exacerbating inflammation, contributes to the onset of atherosclerosis. However, there are inconsistent data concerning markers of systematic inflammation in H. pylori-positive subjects [107][108][109] . This inconsistency can be attributed to differences in the studied ethnic groups, as different groups may develop inflammatory reactions via distinct mechanisms.…”

Section: H Pylori and Endothelial Dysfunctionmentioning

confidence: 99%

Helicobacter pylori—An Infectious Risk Factor for Atherosclerosis?

Yang

Lü

2014

JAT

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Accumulating evidence implicates Helicobacter pylori (H. pylori) infection in the pathogenesis of certain diseases localized outside the stomach, particularly those characterized by persistent and lowgrade systematic inflammation. Recently, the role of H. pylori infection in the development of atherosclerosis and its clinical complications has received attention. Atherosclerosis is a high-cost disease, and acute events resulting from this condition rank first among morbidity and mortality statistics in most industrialized countries. Atherosclerosis is a multifactorial disorder, and traditional risk factors explain only 50% of its etiology. Therefore, identifying new risk factors for atherosclerosis is necessary. Serological studies indicate that chronic H. pylori infection, especially that with more virulent strains, may predispose patients to the onset of atherosclerosis and related adverse clinical events, and PCR studies have detected H. pylori DNA in atherosclerotic plaques, although this finding remains controversial. If this association were to be confirmed, its importance to public health would be substantial, as the eradication of H. pylori is more straightforward and less costly than the longterm treatment of other risk factors. This review investigates the potential relationship between H. pylori infection and atherosclerosis from both epidemiological and pathogenic perspectives and characterizes the potential mechanisms underlying this correlation.

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The relationship between Helicobacter pylori IgG titre and coronary atherosclerosis

Abstract: Helicobacter pylori IgG titres do not play an important role in the presentation of CAD and do not increase systemic inflammatory response. However, Helicobacter pylori IgG antibody titres may be correlated with the extent of CAD.

Cited by 30 publications

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Helicobacter pylori Seropositivity in Patients with Acute Coronary Syndromes

Helicobacter pylori Seropositivity in Patients with Acute Coronary Syndromes

Flow Mediated Dilation and Carotid Intima Media Thickness in Patients With Chronic Gastritis Associated With Helicobacter Pylori Infection

Helicobacter pylori—An Infectious Risk Factor for Atherosclerosis?

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