Flow Mediated Dilation and Carotid Intima Media Thickness in Patients With Chronic Gastritis Associated With Helicobacter Pylori Infection

Judaki, Arezo; Norozi, Siros; Ahmadi, Mohammad Reza; Ghavam, Samira Mis; Asadollahi, Khairollah; Rahmani, Asghar

doi:10.1590/s0004-2803.201700000-39

Cited by 9 publications

(19 citation statements)

References 19 publications

(19 reference statements)

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“…Atherosclerosis like vascular events have been reported in patients with H. pylori infection [18,19]. Judaki et al [18] reported more prominent vascular changes in patients with H. pylori-positive chronic gastritis than in H. pylori-negative chronic gastritis. Some studies have also reported decreased gastric microcirculation in patients with H. pylori infection [12,20].…”

Section: Discussionmentioning

confidence: 99%

“…This abnormalities occurs by different mechanisms like changes in serum lipid levels, and the metabolism and production of oxidative stress [17]. Atherosclerosis like vascular events have been reported in patients with H. pylori infection [18,19]. Judaki et al [18] reported more prominent vascular changes in patients with H. pylori-positive chronic gastritis than in H. pylori-negative chronic gastritis.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of celiac artery blood flow in children with chronic active gastritis

Akbulut¹,

Özkan²,

Işık³

et al. 2021

Pamukkale Medical Journal

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Evaluation of celiac artery blood flow in children with chronic active gastritis

Akbulut¹,

Özkan²,

Işık³

et al. 2021

Pamukkale Medical Journal

View full text Add to dashboard Cite

show abstract

“…Using high-frequency ultrasonographic imaging of the brachial artery, it was found that endotheliumdependent flow-mediated vasodilation (FMD) was significantly lower in the subjects with seropositive antibodies to H. pylori than in the ones with seronegative antibodies to H. pylori, while endothelium-independent nitroglycerin-induced vasodilation was similar in both groups [50]. Similarly, another study with patients with chronic gastritis associated with H. pylori infection demonstrated that the level of FMD in patients with positive H. pylori infection was significantly lower than those with negative H. pylori infection and the healthy control group [51]. Studies also showed that the levels of C-reactive protein and soluble intercellular adhesion molecule-1 (ICAM-1) were significantly higher in subjects with seropositive antibodies to H. pylori than in those with seronegative antibodies to H. pylori [50].…”

Section: H Pylori Infection and Endothelial Dysfunction 41 H Pylori Infection And Endothelial Dysfunction In Patientsmentioning

confidence: 90%

Helicobacter pylori Infection and Endothelial Dysfunction

Xia¹,

Zhang²,

Xu³

et al. 2021

Helicobacter Pylori - From First Isolation to 2021

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Endothelial cells play a critical role in maintaining the integrity of vascular structure and function. Endothelial dysfunction is closely associated with the development and progression of cardiovascular diseases (CVDs) like hypertension (HTN) and atherosclerosis. Gut microorganisms significantly contribute to atherosclerosis and related CVDs. Helicobacter pylori (H. pylori) colonizes in human gastric epithelium in a significant portion of general population in the world. Patients with H. pylori infection have significantly increased risk for CVDs including atherosclerosis, HTN, coronary heart disease, and cerebrovascular disease especially in younger patients (< 65 years old). H. pylori infection significantly impairs vascular endothelial function through multiple mechanisms including increased reactive oxygen species production and oxidative stress, inflammation, decreased nitric oxide formation, modification of the expression of cytokines and microRNAs, abnormalities of lipid and glucose metabolisms, and exosomes-mediated pathways. Endothelial dysfunction associated with H. pylori infection is reversible in both animal model and human subjects. Accumulating data suggests that H. pylori infection is an important risk factor for endothelial dysfunction and CVDs especially in young patients. Screening young male population for H. pylori infection and treating accordingly could be an effective approach for early prevention of CVDs especially premature atherosclerosis associated with H. pylori infection.

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“…Some endothelial dysfunction biomarkers such as endothelin-1 (ET-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), and intercellular adhesion molecule-1 (ICAM-1), were significantly increased in patients with H. pylori infection, indicating that patients with H. pylori infection are at risk of endothelial dysfunction. 65,66 In addition, some available evidence has revealed that the H. pylori virulence factor VacA may be involved in endothelial dysfunction by leading to vacuole formation in endothelial cells and has a significant proatherogenic effect. 67 Based on the above findings, some researchers believe that H. pylori infection could start and (or) accelerate the process of AS.…”

Section: Helicobacter Pylori and Endothelial Dysfunctionmentioning

confidence: 99%

Extracellular vesicles from helicobacter pylori‐infected cells and helicobacter pylori outer membrane vesicles in atherosclerosis

Qiang

Tian

et al. 2022

Helicobacter

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Background The role of H. pylori infection has been reported in various extragastric diseases, particularly, the correlation between H. pylori and atherosclerosis (AS) have received lots of attention. Some scholars demonstrated that the presence of H. pylori‐specific DNA in the sclerotic plaques of atheromatous patients provides biological evidences, with indicating that H. pylori infection is a potential factor of AS. However, the underlying mechanism of H. pylori or their products cross the epithelial barriers to enter the blood circulation remains unclear. Recent studies have shown that the extracellular vesicles (EVs) derived from H. pylori‐infected gastric epithelial cells encapsulated H. pylori virulence factor cytotoxin‐associated gene A (CagA) and existed in the blood samples of patients or mice, which indicating that they can carry CagA into the blood circulation. Based on these findings, some researchers proposed a hypothesis that H. pylori is involved in the pathogenesis of AS via EVs‐based mechanisms. In addition, outer membrane vesicles (OMVs) serve as transport vehicles to deliver H. pylori virulence factors to epithelial cells. It is necessary to discuss the role of H. pylori OMVs in the development of AS. Objectives This review will focus on the correlation between H. pylori infection and AS and tried to unveil the possible role of EVs from H. pylori‐infected cells and H. pylori OMVs in the pathogenesis of AS, with a view to providing help in refining our knowledge in this aspect. Methods All of information included in this review was retrieved from published studies on H. pylori infection in AS. Results H. pylori infection may be an atherosclerotic risk factor and drives researchers to reevaluate the role of H. pylori in the pathogenesis of AS. Some findings proposed a new hypothesis that H. pylori may be involved in the pathogenesis of AS through EVs‐based mechanisms. Besides EVs from H. pylori‐infected cells, whether H. pylori OMVs may play some role in the pathogenesis of AS is still remain unclear. Conclusion Existing epidemiological and clinical evidence had shown that there is a possible association between H. pylori and AS. However, except for the larger randomized controlled trials, more basic research about EVs from H. pylori‐infected cells and H. pylori OMVs is the need of the hour to unveil the possible role of H. pylori infection in the pathogenesis of AS.

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Flow Mediated Dilation and Carotid Intima Media Thickness in Patients With Chronic Gastritis Associated With Helicobacter Pylori Infection

Abstract: -Background -Endothelial dysfunction is one of the early stages of vascular diseases. Objective -The aim of this study was to investigate the endothelial dysfunction markers in patients with chronic gastritis associated with

Cited by 9 publications

References 19 publications

Evaluation of celiac artery blood flow in children with chronic active gastritis

Evaluation of celiac artery blood flow in children with chronic active gastritis

Helicobacter pylori Infection and Endothelial Dysfunction

Extracellular vesicles from helicobacter pylori‐infected cells and helicobacter pylori outer membrane vesicles in atherosclerosis

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