The relationship between epilepsy and sexual dysfunction: a review of the literature

Abstract

Background and objectivesRegardless of the disease states that people suffer from, maintaining sexual function is an important indicator of quality of life. The objective of this review was to figure out the relationship between epilepsy, antiepileptic drugs (AEDs) and sexual dysfunction.ResultsIn various epidemiological and clinical studies, epilepsy has been correlated with a reduction in sexual function. This sexual dysfunction is not always detected in epileptic patients until systematic efforts are put in place, as part of the assessment and treatment process. Therefore, precise evaluations of the incidence of treatment related sexual dysfunction in epileptic patients is still lacking.ConclusionsThis literature review concluded that sexual function is influenced by the pathophysiology of epilepsy, as well as through the use of AEDs. To maximize quality of care in patients with epilepsy and those patients with other disease states who receive AEDs, it is important to address the status of the patient’s sexual function as part of the initial routine assessment and with any treatment related follow-up. Minimizing the effects of AED related sexual dysfunction can be achieved by raising awareness among patients, providing education and training for physicians regarding sexual dysfunction and obtaining a baseline sexual history from the patient so are important recommendations. In addition, systematic studies are needed to explore the risk and mechanism of such treatment related side effects on sexual function.

Sexual Dysfunction in Epilepsy and the Role of Anti-Epileptic Drugs

“…Sexual dysfunction affects between 30 to 66% of men (20) with epilepsy and 14 to 50% of women (20). The variability in these figures is related to a number of limitations common to epidemiological studies and which include, lack of a control groups, selection bias, differing adopted clinical instruments and cultural backgrounds.…”

Effect of prescription medications on erectile dysfunction

“…AEDs can be separated into two groups, based on their effect on hepatic enzymes 65. Hepatic enzyme stimulation results in increased sex hormone binding globulin (SHBG) levels, which leads to lower free testosterone levels.…”

WITHDRAWN: Effects of Satureja Edmondi Briq on Ameliorate Reproductive Parameters in Pentylenetetrazol-Induced Epilepsy Models in Rats

“…Sexual dysfunction and fertility problems have been noted in men with epilepsy [4]. Reproductive impairment is attributed both to epilepsy itself and antiepileptic drugs (AEDs) [5]. Epilepsy,antiepileptic drugs (AEDs), and the reproductive system haveintricateinteractions [6].…”