Effect of prescription medications on erectile dysfunction

Razdan, Shirin; Patel, Amir Shahreza; Alameddine, Mahmoud; Jue, Joshua S.; Ramasamy, Ranjith

doi:10.1136/postgradmedj-2017-135233

Cited by 18 publications

(17 citation statements)

References 97 publications

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“…Patients who discontinue these medications because of adverse effects can experience detrimental psychiatric outcomes. 4 Neuropsychiatric medications have a variety of adverse effects due to the multiple receptors targeted throughout the body. These receptors include central and peripheral serotonergic, adrenergic, dopaminergic, cholinergic, histaminergic, and melanocortin receptors.…”

Section: Neuropsychiatrymentioning

confidence: 99%

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Medications Most Commonly Associated with Erectile Dysfunction: Evaluation of the Food and Drug Administration National Pharmacovigilance Database

et al. 2022

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Background Erectile dysfunction (ED) is an adverse effect of many medications. Aim We used a national pharmacovigilance database to assess which medications had the highest reported frequency of ED. Methods The Food and Drug Administration Adverse Event Reporting System (FAERS) was queried to identify medications with the highest frequency of ED adverse event reports from 2010 to 2020. Phosphodiesterase-5 inhibitors and testosterone were excluded because these medications are often used as treatments for men with ED. The 20 medications with the highest frequency of ED were included in the disproportionality analysis. Outcomes Proportional Reporting Ratios (PRRs) and their 95% confidence intervals were calculated. Results The 20 medications accounted for 6,142 reports of ED. 5-α reductase inhibitors (5-ARIs) and neuropsychiatric medications accounted for 2,823 (46%) and 2,442 (40%) of these reports respectively. Seven medications showed significant levels of disproportionate reporting with finasteride and dutasteride having the highest PRRs: 110.03 (103.14–117.39) and 9.40 (7.83–11.05) respectively. The other medications are used in a wide variety of medical fields such as cardiology, dermatology, and immunology. Clinical Implications Physicians should be familiar with these medications and understand their respective mechanisms of action, so that they may counsel patients appropriately and improve their quality of life. Strengths and Limitations The strength of the study is its large sample size and that it captures pharmacologic trends on a national level. Quantitative and comparative “real-world” data is lacking for the most common medications associated with ED. The limitation is that the number of reported events does not establish causality and cannot be used to calculate ED incidence rates. Conclusion In a national pharmacovigilance database, 5-ARIs and neuropsychiatric medications had the highest reports of ED adverse effects. There were many other medications used in a variety of medical fields that were also associated with ED.

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Section: Neuropsychiatrymentioning

confidence: 99%

“…In an age when about 60% of the population reports prescription drug use in a given year, medication-induced ED is an important organic cause of ED. 4 It is estimated that up to 25% of all ED is related to medication use and may be reversible. 5 It is incumbent on physicians to be familiar with these medications.…”

Section: Introductionmentioning

confidence: 99%

Medications Most Commonly Associated with Erectile Dysfunction: Evaluation of the Food and Drug Administration National Pharmacovigilance Database

et al. 2022

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“…There is a wide range of risk factors for ED, including age, obesity, smoking, depression, hypertension, various medications, history of pelvic surgery, spinal cord lesions and psychological variables (Razdan et al, 2018). In this respect, many common conditions like depression and widely used medications are related to the aetiology of ED (Nguyen et al, 2017).…”

Section: C-reactive Protein-albumin Ratio and Erectile Dysfunctionmentioning

confidence: 99%

C‐reactive protein–albumin ratio and erectile dysfunction

Balta

Mikhailidis

2022

Andrologia

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“…It is associated with underlying comorbidities such as cardiovascular disease [ 2 ] and metabolic syndrome [ 3 ], and it has been shown that men with ED have a significantly higher chance of a cardiovascular event in the years following diagnosis [ 4 ]. Multiple factors may contribute to ED, including hypertension [ 5 ], diabetes [ 6 ], psychological disorders [ 7 ], medications [ 8 ], hypogonadism [ 9 ], and sleep disorders [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Contemporary cost-analysis comparison of direct-to-consumer vs. traditional prescriptions of phosphodiesterase-5 inhibitors

et al. 2022

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After a focused telehealth visit, patients can now access phosphodiesterase-5 inhibitor (PDE5 inhibitor) prescriptions through online direct-to-consumer (DTC) healthcare companies. This study seeks to quantify the cost of DTC PDE5 inhibitor treatment compared to a traditional physician visit and local pharmacy prescription. Two DTC companies, two compounding pharmacies with national reach, three online Canadian pharmacies, and sixteen American pharmacy chains were queried for prices of 90-day regimens of common PDE5 inhibitors. Prices for chains were determined using their publicly available price on GoodRx ® with coupon. Cost of physician visit was determined using 2020 Center for Medicare and Medicaid Services reimbursement for a level 3 new patient visit. For sildenafil 20 mg, a physician visit and local prescription cost a low of $125.45 compared to $144.35 for compounding, $169.34 for Canadian, and $195.00 for DTC. For sildenafil 100 mg, a physician visit and local prescription cost a low of $137.16 compared to $289.35 for compounding, $200.36 for Canadian, and $900.00 for DTC. For tadalafil 5 mg, a physician visit and local prescription cost a low of $125.80 compared to $169.35 for compounding, $195.34 for Canadian, and $720.00 for DTC. For tadalafil 20 mg, a physician visit and local prescription cost a low of $161.00 compared to $289.35 for compounding, $229.00 for Canadian, and $2880.00 for DTC. Thus, local pharmacies, in conjunction with online coupons, consistently provide a markedly less-expensive option for fulfillment of PDE5 inhibitor prescriptions than online DTC services.

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Effect of prescription medications on erectile dysfunction

Cited by 18 publications

References 97 publications

Medications Most Commonly Associated with Erectile Dysfunction: Evaluation of the Food and Drug Administration National Pharmacovigilance Database

Medications Most Commonly Associated with Erectile Dysfunction: Evaluation of the Food and Drug Administration National Pharmacovigilance Database

C‐reactive protein–albumin ratio and erectile dysfunction

Contemporary cost-analysis comparison of direct-to-consumer vs. traditional prescriptions of phosphodiesterase-5 inhibitors

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