The relationship between dialysis adequacy and serum uric acid in dialysis patients; a cross-sectional multi-center study in Iranian hemodialysis centers

Abstract

Introduction: Uric acid is one of the most significant uremic toxins accumulating in chronic renal failure patients treated with standard dialysis. Its clearance has not any exact relation with urea and creatinine clearance. Objectives: The aim of this study was to investigate the relationship between adequacy of dialysis and serum level of uric acid in dialysis patients of some dialysis centers in Iran. Patients and Methods: In this study 1271 hemodialysis patients who have been treated for more than 3 months were evaluated. Their information and examinations from their files in all over the country were gathered and analyzed using SPSS versin18.0. Results: In this study, a significant relationship between dialysis duration and serum level of uric acid was not detected, however, a significant relationship between patients Kt/V and uric acid (R=0.43, P=0.029) was seen. Patients who had higher adequacy of dialysis had a higher level of plasma uric acid. Conclusion: For better controlling of plasma uric acid level of hemodialysis patients, increasing of the adequacy of dialysis or its duration is not effective. Other modalities of decreasing of serum uric acid like, changing diet or lifestyle or medical therapy may be necessary.

The Relationship Between Nutritional Status Based on Subjective Global Assessment and Dialysis Adequacy

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Adequacy of Dialysis in Iranian Patients Undergoing Hemodialysis: A Systematic Review and Meta-Analysis

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The relationship between uric acid concentration and cardiovascular risk: Retrospective analysis of patients on hemodialysis

“…sugerišu da je efikasnost kontrolisanja koncentracije MK nezavisna od povećane adekvatnosti ili trajanja dijalize, tj. da je neophodno promeniti ishranu, stil života i primeniti odgovarajuću terapiju za korigovanje hiperurikemije (17). S druge strane, u našoj studiji statistički značajna regresija dobijena je između koncentracije MK i parametara muški pol, godine starosti, urea i neorganski fosfat.…”