The Relationship between Diabetes mellitus, Impotence and Veno-Occlusive Dysfunction in Peyronie’s Disease Patients

Çulha, Melih; Alıcı, Bülent; Acar, Ömer; Mutlu, N; Gökalp, Ayşe Sevim

doi:10.1159/000030220

Cited by 19 publications

(5 citation statements)

References 23 publications

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“…Schwarzer et al [5] found that the incidence of PD was three times greater in diabetics than non‐diabetics. Culha et al [16] also found a close relationship between diabetes mellitus and PD. On the contrary, Lindsay et al [8] reported that the incidence of diabetes mellitus was low among men with PD.…”

Section: Discussionmentioning

confidence: 94%

Risk factors for Peyronie's disease: a case‐control study

Bjekić¹,

Vlajinac²,

Šipetić³

et al. 2006

BJU International

135

107

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RESULTSFrom the multivariate logistic regression analysis the risk factors for PD were: a history of genital and/or perineal injuries, transurethral prostatectomy, cystoscopy, diabetes mellitus, hypertension, lipoma, propranolol in therapy, Dupuytren's contracture in the medical history, ever having smoked, alcohol consumption, fibromatous lesions of the genital tract of the partner, and surgical intervention on the genital tract of the partner. CONCLUSIONThe results of the present study are in line with the hypothesis that, in addition to genetic predisposition, trauma of the penis and systemic vascular diseases are risk factors for PD. Smoking and alcohol consumption also seem to have some role in the development of the disease.

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Section: Discussionmentioning

confidence: 94%

Risk factors for Peyronie's disease: a case‐control study

Bjekić¹,

Vlajinac²,

Šipetić³

et al. 2006

BJU International

135

107

View full text Add to dashboard Cite

show abstract

“…However, it should be noted that the study never examined whether PD (TA plaque) caused veno-occlusive dysfunction or ED. In another study that evaluated 143 PD patients, only 27 (19%) were found to have concomitant ED, and 22 (including 4 diabetics) of the 27 PD+ED patients were found to have veno-occlusive dysfunction [73]. So, on one hand, these two studies disagree sharply in the prevalence of ED among PD patients (80% versus 19%), but on the other, they do agree that veno-occlusive dysfunction is the principal cause of ED in PD patients.…”

Section: Peyronie's Disease-associated Edmentioning

confidence: 98%

Advances in Stem Cell Therapy for Erectile Dysfunction

Lin

2014

Advances in Andrology

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Stem cell (SC) therapy for erectile dysfunction (ED) has been investigated in 35 published studies, with one being a small-scale clinical trial. Out of these 35 studies, 19 are concerned with cavernous nerve (CN) injury-associated ED while 10 with diabetes mellitus-(DM-) associated ED. Adipose-derived SCs (ADSCs) were employed in 18 studies while bone marrow SCs (BMSCs) in 9. Transplantation of SCs was done mostly by intracavernous (IC) injection, as seen in 25 studies. Allogeneic and xenogeneic transplantations have increasingly been performed but their immune-incompatibility issues were rarely discussed. More recent studies also tend to use combinatory therapies by modifying or supplementing SCs with angiogenic or neurotrophic genes or proteins. All studies reported better erectile function with SC transplantation, and the majority also reported improved muscle, endothelium, and/or nerve in the erectile tissue. However, differentiation or engraftment of transplanted SCs has rarely been observed; thus, paracrine action is generally believed to be responsible for SC's therapeutic effects. But still, few studies actually investigated and none proved paracrine action as a therapeutic mechanism. Thus, based exclusively on functional outcome data shown in preclinical studies, two clinical trials are currently recruiting patients for treatment with IC injection of ADSC and BMSC, respectively.

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“…PDE5 enzyme [19][20][21][22][23][24][25] converts cGMP into 5' AMP then lowering cGMP levels that are needed for the erection process. Medications such as sildefanil block the PDE5 enzyme then increasing and maintaining levels of cGMP necessary for the erection process.…”

Section: Erection Processmentioning

confidence: 99%

Adipose-derived adult stem cells and new technique for intracavernosal injection for erectile dysfunction: novel approach to treat diabetes mellitus. Erectus Shot Technique

Mercado¹

2016

Integr Mol Med

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Erectile Dysfunction (ED) affects 10 percent of the population worldwide. In 1995 it was estimated that 152 million men were affected by ED. It is estimated that by 2025 352 million of population worldwide will be affected. Currently there is not available treatment that can restore or regenerate the tissues in the corpus cavernosum or arterial system tthat will cure ED a 20 percent failure rate with present therapies and high rate of drop out in patients with ED due to radical prostatectomy and post radiation. Testosterone eplacement is the only independent risk factor that might help endothelial dysfunction and consequently ED. Adipose tissue is abundant and easy to collect from a miniliposuction. The procedure consists in collecting a lipoaspirate of 60 ml. No general Anesthesia is required. It is an outpatient procedure. Adipose tissue is processed using a non animal collagenase enzyme. Stromal vascular fraction (SVF) is isolated. Blood is obtained through a venipuncture. Platelet rich-plasma (PRP) is obtained. The SVF is suspended in PRP. The mixture is injected into the corpus cavernosum using our designed protocol for injection.Four types of patients: DM, ED due to prostatectomy and radiation, Peyronie's disease, and ED organic cause/aging/vascular. Patients filled out the intensity score questionnaire before and after procedure. Both reported better erections in the morning, firmer, and better response to PDI5 inhibitors for which they were not responders prior to the treatment. This might be due to stem cells induced regeneration of the cavernous nerve and endothelial cells enhancing the nitric oxide production hence improved response to PDI-5 inhibitors.

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The Relationship between Diabetes mellitus, Impotence and Veno-Occlusive Dysfunction in Peyronie’s Disease Patients

Cited by 19 publications

References 23 publications

Risk factors for Peyronie's disease: a case‐control study

Risk factors for Peyronie's disease: a case‐control study

Advances in Stem Cell Therapy for Erectile Dysfunction

Adipose-derived adult stem cells and new technique for intracavernosal injection for erectile dysfunction: novel approach to treat diabetes mellitus. Erectus Shot Technique

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