The relationship between depression and mortality in 
elderly subjects with less severe dementia

Janzing, J.G.E.; Bouwens, J. M. P.; Teunisse, Robert J.; Zitman, F.G.

doi:10.1017/s003329179900865x

Cited by 28 publications

(27 citation statements)

References 16 publications

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“…Apart from face validity, the relevance of these factors was shown by differential relationships with clinical characteristics. Mood symptoms have been found to be predictive of short-term mortality in subjects with dementia, whereas motivation symptoms were associated with the severity of dementia [4,11,25] .…”

Section: Discussionmentioning

confidence: 99%

Depressive Symptoms Predict Slow Cognitive Decline in Mild Dementia

Janzing¹,

Naarding²,

Eling³

2005

Dement Geriatr Cogn Disord

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Depression may be a prognostic marker of subsequent cognitive decline in patients with dementia. Earlier investigations did not find support for this hypothesis, but these considered mainly syndromal depression. In this prospective study, 32 subjects with mild dementia were followed up for 12 months. The effects of GMS-AGECAT syndromal depression, subsyndromal depression and dimensions of depressive symptoms were studied. Higher levels of mood symptoms but not (sub)syndromal depression predicted slower cognitive decline during follow-up. It is hypothesized that the report of depressive symptoms by subjects with mild dementia reflects relative intactness of cognitive functions, not accounted for by cognitive screening instruments.

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Section: Discussionmentioning

confidence: 99%

Depressive Symptoms Predict Slow Cognitive Decline in Mild Dementia

Janzing¹,

Naarding²,

Eling³

2005

Dement Geriatr Cogn Disord

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“…Depression and mood symptoms have previously been associated with a higher mortality in AD [35], but this effect is likely to be non-specific, as mood disorders have been related to an increased mortality in non-demented elderly as well [36,37].…”

Section: Discussionmentioning

confidence: 99%

Mortality in Alzheimer’s Disease

Bonsignore

Heun²

2003

Dement Geriatr Cogn Disord

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Objective: This study examines the relevance of variables suspected to influence mortality in Alzheimer’s disease (AD). Methods: 172 subjects with AD recruited through a family study were followed up for a mean of 4.7 ± 2.6 years. Their survival was compared with that of matched control subjects using Kaplan-Meier and log-rank statistics. Variables determining mortality were examined with the Cox proportional hazards model. Results: Survival in subjects with AD depended on age, the severity of cognitive decline and on the incidence of hospitalisation. Gender, the duration of the illness, the velocity of cognitive decline, the allele E4 of the apolipoprotein E genotype and the presence of other lifetime psychiatric diagnoses did not influence mortality. Conclusion: Mortality in AD depended mainly on the subjects’ age and the severity of the disorder.

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“…These patients also have greater difficulty in restoring social activities (6). Several studies have described a higher mortality rate in stroke patients with depression (7), and certain studies have reported that PSD patients using antidepressant drugs demonstrate improved ability to function than those without antidepressant therapy. The treatment of depression has been demonstrated to aid functional recovery (8), meaning that the early diagnosis and effective treatment of PSD are crucial to recovery from a stroke.…”

Section: Introductionmentioning

confidence: 99%

Estrogen therapy increases BDNF expression and improves post-stroke depression in ovariectomy-treated rats

Cheng

Jin

et al. 2016

Experimental and Therapeutic Medicine

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Abstract. The present study investigated the effect of exogenous estrogen on post-stroke depression. Rats were exposed to chronic mild stress following middle cerebral artery occlusion. The occurrence of post-stroke depression was evaluated according to the changes in preference for sucrose and performance in a forced swimming test. Estrogen therapy significantly improved these neurological symptoms, indicating that estrogen is effective in treating post-stroke depression. Increased brain-derived neurotrophic factor (BDNF) expression was reported in the hippocampus of rats that had been treated with estrogen for two weeks, suggesting that BDNF expression may be an important contributor to the improvement of post-stroke depression that is observed following estrogen therapy. IntroductionDepression is a common complication of stroke, occurring in ~33% of patients (1,2); the clinical symptoms of this include feelings of guilt, low self-esteem, reduction in food intake, sleep disorders and fatigue. There are between 1.6-2.0 million new stroke patients in China every year and post-stroke depression (PSD) is closely associated with the increased risk of mortality following a stroke (3). PSD negatively impacts upon subsequent rehabilitation; in a previous study by Sinyor et al, PSD patients demonstrated greater functional impairment than patients without depression, also scoring lower on behavioral action and functional status (4). The severity of depression is closely associated with health-associated quality of life and functional recovery in stroke survivors (5). PSD patients demonstrate a negative mood during rehabilitation and achieve poorer outcomes during functional recovery therapy. These patients also have greater difficulty in restoring social activities (6). Several studies have described a higher mortality rate in stroke patients with depression (7), and certain studies have reported that PSD patients using antidepressant drugs demonstrate improved ability to function than those without antidepressant therapy. The treatment of depression has been demonstrated to aid functional recovery (8), meaning that the early diagnosis and effective treatment of PSD are crucial to recovery from a stroke.Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family, which regulates neurogenesis (9), apoptosis (10), the expression level of monoamine transmitters (11), and the function and plasticity of synapses (12). Neurotrophins may be key in the development of depression (13); BDNF, for instance, can activate intracellular mitogen-activated protein kinase/extracellular signal-regulated kinase cascade signaling pathways (14), affecting synaptic plasticity (12) and alleviating the symptoms of depression (15), and BDNF may thus be important in the maintenance of emotional stability. Deletion of the BDNF receptor induces a reduction in neurogenesis and increases anxious behavior (16). Additionally, BDNF expression is associated with 5-hydroxytryptamine receptor expression in the brain, particularly the hi...

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The relationship between depression and mortality in elderly subjects with less severe dementia

Abstract: Short-term mortality in elderly subjects with less severe dementia is predicted by the presence of (sub) syndromal depression and by mood symptoms. The effects of depression and severity of dementia on the mortality rates seem to be largely independent.

Cited by 28 publications

References 16 publications

Depressive Symptoms Predict Slow Cognitive Decline in Mild Dementia

Depressive Symptoms Predict Slow Cognitive Decline in Mild Dementia

Mortality in Alzheimer’s Disease

Estrogen therapy increases BDNF expression and improves post-stroke depression in ovariectomy-treated rats

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