Depressive Symptoms Predict Slow Cognitive Decline in Mild Dementia

Janzing, J.G.E.; Naarding, Paul; Eling, Paul

doi:10.1159/000085859

Cited by 7 publications

(4 citation statements)

References 33 publications

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“…This hypothesis is consistent with the results reported by Janzing et al [9] in a small observational study of subjects with mild dementia, in whom the number of depressive symptoms was inversely related to cognitive decline over 12 months, independent of changes in mood status. However, this inverse relationship between depression and cognitive outcome is not supported by epidemiological and neuropathological studies [41,42] and is contradicted by other clinical investigations suggesting an opposite association [8] .…”

Section: Discussionsupporting

confidence: 93%

“…In some cross-sectional reports, AD patients with major depression had greater cognitive impairment than nondepressed patients [5] , especially in the early stages of dementia [6] , a result not confirmed by other studies [7] . Contrasting findings were reported in longitudinal studies, in which baseline depressive symptoms predicted either a faster [8] or a slower cognitive decline [9] , or no effect at all [10] .…”

Section: Introductioncontrasting

confidence: 91%

See 1 more Smart Citation

Is Antidepressant Treatment Associated with Reduced Cognitive Decline in Alzheimer’s Disease?

Mossello

Boncinelli

Caleri

et al. 2008

Dement Geriatr Cogn Disord

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Background: Although antidepressant drugs (ATD) are frequently prescribed to patients with Alzheimer’s disease (AD), their effect on cognitive status has been only rarely assessed. Methods: The impact of depressive symptoms and ATD on cognitive status was retrospectively assessed in 72 older AD outpatients with mild-to-moderate cognitive impairment, treated with cholinesterase inhibitors, over a 9-month follow-up. Results: Compared to subjects without baseline depressive symptoms, those with symptoms who were continuously treated with ATD had less cognitive decline; those never treated, or not continuously treated despite baseline symptoms, had an intermediate trend. Such a protective action of ATD was, at least in part, independent of their action on depressive symptoms. Conclusion: These observations suggest that ATD may reduce cognitive decline in depressed older AD patients.

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Section: Discussionsupporting

confidence: 93%

Section: Introductioncontrasting

confidence: 91%

Is Antidepressant Treatment Associated with Reduced Cognitive Decline in Alzheimer’s Disease?

Mossello

Boncinelli

Caleri

et al. 2008

Dement Geriatr Cogn Disord

View full text Add to dashboard Cite

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“…Diagnoses were then made using the Automated Geriatric Examination for Computer-Assisted Taxonomy computer program (AGECAT) [22]. It is documented that the GMS-AGECAT system performs well in diagnosing depression and dementia [23,24]. …”

Section: Methodsmentioning

confidence: 99%

Do Depression and Educational Attainment Mediate the Association between Ethnicity and Dementia?

Momtaz

Hamid²,

Yusoff³

et al. 2012

Gerontology

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Introduction: Research shows marked differences in the prevalence of dementia among different ethnic groups. However, there is a relative dearth of studies focusing on how ethnicity may influence dementia. The main aim of the current study is to test potential mediating effects of depression and level of education on the association between ethnicity and dementia. Methods: The sample for this study, consisting of 2,796 community-dwelling elderly people aged 60 years and older, was drawn from a cross-sectional national survey entitled ‘Mental Health and Quality of Life of Older Malaysians'. The Malaysian adapted version of the Geriatric Mental State-Automated Geriatric Examination for Computer-Assisted Taxonomy was used to assess dementia and depression. Data analysis was conducted using IBM SPSS version 19. Results: As expected, the result of the χ² analysis revealed significant ethnic difference in the prevalence of dementia (χ² = 58.05, p ≤ 0.001). The results of the mediational analyses revealed that depression (Z = 4.05, p ≤ 0.001) and education (Z = 2.78, p ≤ 0.01) significantly, but partially, mediate the association between ethnicity and dementia. This suggests that disparities of depressive symptoms and education contribute to ethnic difference in the prevalence of dementia. Conclusions: These findings provide more insight into how ethnicity may influence an individual's vulnerability to dementia. The limitations of the study along with implications of the findings and needs for further study are discussed.

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“…In Alzheimer's classic case description (1906) psychotic symptoms were among the prominent manifestations of the disease (2). It has been disputable about prevalence of different BPSD in demented patients (1,16,19). The rates of all the psychotic symptoms vary widely depending on how the phenomena are defined, patients' sample, stage of the disease, accurate data, investigator's skills, etc.…”

Section: Introductionmentioning

confidence: 99%

Upon Type, Frequency and Some Clinical Aspects of Psychotic Symptoms in Alzheimer’s Disease

Arnaoudova¹

2011

JofIMAB

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SUMMARY:Various psychotic disorders develop often at different stages of the disease. A comprehensive approach of type, frequency and clinical aspects of the psychotic disorders patients with Alzheimer's disease (AD) can optimize management of these conditions in patients with dementia. We examined 120 patients with probable AD. The routine clinical examination and observation were used to delineate the most common psychotic symptoms. Delusions, found in the explored patients were predominantly paranoid. The delusions are often short lived and lack complexity of that seen in schizophrenia. In number of cases they are difficult to be distinguished from confabulations. Hallucinations were mostly verbal, visual and tactile. Misidentification syndromes were identified in a considerable number of patients. They are often disputable or have been classified as delusions or hallucinations, depending on interpretation of psychotic phenomena. We discuss different forms of misidentification. The presence of psychotic symptoms predicts the occurrence and frequency of different forms of aggression and destructive behavior.Key words: Alzheimer's disease, psychotic symptoms, BPSD INTRODUCTION:Various psychotic disorders develop often at different stages of Alzheimer's disease (AD). Behavioral and Psychological Symptoms of Dementia (BPSD) are an integral part of the disease process. In Alzheimer's classic case description (1906) psychotic symptoms were among the prominent manifestations of the disease (2). It has been disputable about prevalence of different BPSD in demented patients (1,16,19). The rates of all the psychotic symptoms vary widely depending on how the phenomena are defined, patients' sample, stage of the disease, accurate data, investigator's skills, etc. A psychosis of Alzheimer's disease has been accepted since the 1999 conference of the International Psychogeriatric Association (IPA). Psychotic symptoms are among the most intrusive and difficult BPSD to cope with. Estimates of their frequency differ in a broad range (17, 20 Papers) 2011, vol. 17, book 1 and clinical aspects of the psychotic disorders in AD patients can optimize management of these conditions in patients with dementia. Journal of IMAB -Annual Proceeding (Scientific

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Depressive Symptoms Predict Slow Cognitive Decline in Mild Dementia

Cited by 7 publications

References 33 publications

Is Antidepressant Treatment Associated with Reduced Cognitive Decline in Alzheimer’s Disease?

Is Antidepressant Treatment Associated with Reduced Cognitive Decline in Alzheimer’s Disease?

Do Depression and Educational Attainment Mediate the Association between Ethnicity and Dementia?

Upon Type, Frequency and Some Clinical Aspects of Psychotic Symptoms in Alzheimer’s Disease

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