The relationship between depression and physical symptom burden in advanced cancer

Abstract

These findings support the view that a synergistic relationship exists between depression and a broad array of physical symptoms in patients with advanced cancer.

Depression and hopelessness in patients with acute leukemia: the psychological impact of an acute and life‐threatening disorder

“…We have demonstrated in metastatic cancer that depression represents a final common pathway of distress related to burden of disease and to such individual factors such as self‐esteem, the sense of meaning, and attachment security . Depressive symptoms in the present study were associated with a greater number of physical symptoms and distress about these symptoms, and with lower spiritual meaning and peace, similar to findings in patients with metastatic cancer . We have also shown that depression contributes to the amplification of somatic symptoms .…”

The biopsychosocial model in cancer pain

“…Cross-sectional research has consistently found that many factors including greater depression [15], anxiety [17], distress [18], and lower quality of life [19] are correlated with greater pain levels among cancer patients. Cross-sectional research has consistently found that many factors including greater depression [15], anxiety [17], distress [18], and lower quality of life [19] are correlated with greater pain levels among cancer patients.…”

Systematic review and meta-analysis of collaborative care interventions for depression in patients with cancer

“…Depressive disorders in the context of cancer can have clinically relevant effects on health outcomes. Depression has been associated with more prolonged hospital stays, increased physical distress, poorer treatment compliance, lower quality of life, and increased desire for hastened death . More severe depression in cancer has also been shown to be a risk factor for death, independent of medical variables .…”