The relationship between depression and executive function and the impact of vascular disease burden in younger and older adults

Lugtenburg, Astrid; Voshaar, Richard C. Oude; Zelst, Willeke van; Schoevers, Robert A.; Enriquez‐Geppert, Stefanie; Zuidersma, Marij

doi:10.1093/ageing/afx043

Cited by 13 publications

(9 citation statements)

References 21 publications

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“…Compatible with our results, in other cross-sectional study, usual WS was associated with executive function on the TMT-B (β = −0.22, p = 0.003) [29]. In addition, a population-based cohort study included 9,402 older adults aged 60 or more had reported that major depression was associated with worse executive function across the lifespan (adjusted for age, gender, and level of education, β = −5.10, p < 0.01) [30].…”

Section: Discussion/conclusionmentioning

confidence: 99%

Polypharmacy and Lack of Joy Are Related to Physical Frailty among Northern Japanese Community-Dwellers from the ORANGE Cohort Study

Kume

Takahashi²,

Itakura

et al. 2021

Gerontology

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Introduction: A prevalence of frailty is gradually increasing with the progress of aging in Japan, and critical challenges regarding early diagnosis and prevention of frailty were necessary in community. Although previous studies have well documented the characteristics of physical disability, there is limited information on frail state differences among older adults in Japanese rural areas. The aim of our cross-sectional observational study was to clarify the association of frail status in northern Japanese community-dwellers aged 65 or more. Methods: 345 participants were recruited from 2018 to 2020, and after getting informed consent from each participant, assessments and outcomes were evaluated according to the ORANGE protocol. We applied the frailty index of Gerontology-the Study of Geriatric Syndromes (NCGG-SGS) to classify frailty status by collecting data of demographics and psychosocial status using the Kihon checklist (KCL) and cognitive domains used by the National Center for Geriatrics and Gerontology-Functional Assessment Tool (NCGG-FAT). Results: Our subjects included 313 older adults divided into 138 robust, 163 prefrail, and 12 frail. For statistical analysis, we found that the frail group had a lower educational duration, worsened KCL items, lower cognitive functions, and a tendency toward depression compared to the other groups. Moreover, physical frailty and cognitive decline were related, and polypharmacy and a lack of joy in daily life were explanatory variables of frail status. Conclusions: We suggest that KCL is important for frail discrimination, and in order to prevent physical frailty, our community should take care of not only exercise and nutrition but also cognitive functioning and depressive tendencies. In particular, polypharmacy and the presence of fun in your life are possible to be related to frailty.

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Section: Discussion/conclusionmentioning

confidence: 99%

Polypharmacy and Lack of Joy Are Related to Physical Frailty among Northern Japanese Community-Dwellers from the ORANGE Cohort Study

Kume

Takahashi²,

Itakura

et al. 2021

Gerontology

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“…Moderate and severe depression has also been associated with EF impairments as well as sleep disturbance. Thus, the unique contribution of sleep quality to EF may be attributed to depression if it is not controlled for in analyses (Lugtenburg et al, 2017).…”

Section: Methodological Differencesmentioning

confidence: 99%

Sleep Mediates Age-Related Executive Function for Older Adults with Limited Cognitive Reserve

Parker

Bucks

Rainey‐Smith

et al. 2020

J Int Neuropsychol Soc

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Objective: Sleep quantity and quality are associated with executive function (EF) in experimental studies, and in individuals with sleep disorders. With advancing age, sleep quantity and quality decline, as does the ability to perform EF tasks, suggesting that sleep disruption may contribute to age-related EF declines. This cross-sectional cohort study tested the hypothesis that poorer sleep quality (i.e., the frequency and duration of awakenings) and/or quantity may partly account for age-related EF deficits. Method: Community-dwelling older adults (N = 184) completed actigraphic sleep monitoring then a range of EF tasks. Two EF factors were extracted using exploratory structural equation modeling. Sleep variables did not mediate the relationship between age and EF factors. Post hoc moderated mediation analyses were conducted to test whether cognitive reserve compensates for sleep-related EF deficits, using years of education as a proxy measure of cognitive reserve. Results: We found a significant interaction between cognitive reserve and the number and frequency of awakenings, explaining a small (approximately 3%), but significant amount of variance in EF. Specifically, in individuals with fewer than 11 years of education, greater sleep disturbance was associated with poorer EF, but sleep did not impact EF in those with more education. There was no association between age and sleep quantity. Conclusions: This study highlights the role of cognitive reserve in the sleep–EF relationship, suggesting individuals with greater cognitive reserve may be able to counter the impact of disturbed sleep on EF. Therefore, improving sleep may confer some protection against EF deficits in vulnerable older adults.

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“…1,9,15,[17][18][19]35,36 Another point that it is indispensable to discuss is that both anxiety and depression are risk factors for CVD, such as AMI, stroke, and PAD. 1,15,17,30,[34][35][36][37][38] This could be because patients with anxiety/depression tend to have a less healthy lifestyle, with dietary errors and without physical exercise, 33,39 as was observed in our sample, the great majority of whom did not do regular physical exercise. However, in contrast to some other studies, 33,36 this factor did not affect the presence of depression.…”

Section: Discussionmentioning

confidence: 75%

Ansiedade e depressão em pacientes com doença arterial periférica internados em hospital terciário

et al. 2019

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Resumo Contexto Ansiedade e depressão são afecções neuropsiquiátricas altamente prevalentes e estão associadas a doenças crônicas, dor, perda de autonomia, dependência para realização de atividades rotineiras e solidão. A depressão, muitas vezes, possui relação de causa-consequência com outras doenças, como infarto agudo do miocárdio, hipertensão arterial sistêmica (HAS), diabetes mellitus e doença arterial periférica (DAP). Objetivos Estimar a frequência de ansiedade e depressão em pacientes de ambos os sexos com DAP, internados em hospital terciário. Métodos Trata-se de um estudo descritivo, transversal, com uma amostra não aleatória selecionada de forma consecutiva. Para avaliar a ansiedade e a depressão, foi utilizada a Escala Hospitalar de Ansiedade e Depressão (HADS) e, para a DAP, foi utilizado o índice tornozelo-braquial (ITB). Resultados A prevalência de ansiedade nesses pacientes foi de 24,4%, havendo associação entre ansiedade e renda familiar mensal, tabagismo e HAS. Já a prevalência de depressão foi de 27,6%, sendo verificadas associações entre depressão e sexo feminino, em união estável ou casada, que sobrevive com até um salário mínimo, não etilista e hipertensa. Conclusões É possível perceber que há uma alta prevalência de transtornos de ansiedade e depressão nos pacientes com DAP. Esses transtornos são subdiagnosticados e, consequentemente, não são devidamente tratados.

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The relationship between depression and executive function and the impact of vascular disease burden in younger and older adults

Cited by 13 publications

References 21 publications

Polypharmacy and Lack of Joy Are Related to Physical Frailty among Northern Japanese Community-Dwellers from the ORANGE Cohort Study

Polypharmacy and Lack of Joy Are Related to Physical Frailty among Northern Japanese Community-Dwellers from the ORANGE Cohort Study

Sleep Mediates Age-Related Executive Function for Older Adults with Limited Cognitive Reserve

Ansiedade e depressão em pacientes com doença arterial periférica internados em hospital terciário

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