The relationship between dairy products intake and breast cancer incidence: a meta-analysis of observational studies

He, Yujing; Tao, Qinghua; Zhou, Feifei; Si, Yue-Xiu; Fu, Rongrong; Xu, Binbin; Xu, Jiaxuan; Li, Xiangyuan; Chen, Bangsheng

doi:10.1186/s12885-021-08854-w

Cited by 14 publications

(5 citation statements)

References 125 publications

(101 reference statements)

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“…A balanced diet including extra virgin olive oil (LoE2b/B/AGO+), nuts (LoE 2b/B/AGO+) (>10 g/die), reduced consumption of fat (LoE2a/B/AGO+), and reduced consumption of red meat (LoE2b/C/AGO+) may decrease the incidence of breast cancer. For other factors such as supplementation of vitamin D3 (LoE1b/B/AGO+/−), vegetarian or vegan diet (LoE2b/C/AGO+/−), vegetables and fruits (LoE2a/B/AGO+/−), dairy products or phytoestrogens (LoE2a/B/AGO+/−), the data are contradictory regarding the reduction of breast cancer incidence [4, 5]. However, it should be considered that prospective randomized trials to investigate the impact of nutrition aspects on breast cancer risk are almost impossible to conduct.…”

Section: Options For Primary Prevention and Lifestyle Factorsmentioning

confidence: 99%

AGO Recommendations for the Diagnosis and Treatment of Patients with Early Breast Cancer: Update 2022

et al. 2022

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Introduction: The AGO (Arbeitsgemeinschaft Gynäkologische Onkologie, German Gynecological Oncology Group) Task Force on Diagnosis and Treatment of Breast Cancer as an interdisciplinary team consists of specialists from gynecological oncology, pathology, diagnostic radiology, medical oncology, and radiation oncology with a special focus on breast cancer. Methods: The updated evidence-based treatment recommendation 2022 for early breast cancer (EBC) and metastatic breast cancer (MBC) of the AGO Task Force have been released. Results and Conclusion: This paper captures the update of EBC.

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Section: Options For Primary Prevention and Lifestyle Factorsmentioning

confidence: 99%

AGO Recommendations for the Diagnosis and Treatment of Patients with Early Breast Cancer: Update 2022

et al. 2022

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“…Finally, moderate intake of low-fat dairy products is promoted in the DASH diet. A recent meta-analysis of thirty-six observational studies revealed that consumption of dairy products was associated with a decreased risk of breast cancer ( 58 ). In brief, the aforementioned these mechanisms may account for the beneficial association between DASH diet and breast cancer.…”

Section: Discussionmentioning

confidence: 99%

Adherence to the Dietary Approaches to Stop Hypertension diet reduces the risk of breast cancer: A systematic review and meta-analysis

et al. 2023

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BackgroundDespite increasing evidence for the association of adherence to the Dietary approaches to stop hypertension (DASH) diet with breast cancer risk, the results remain inconclusive. The purpose of the current systematic review was to summarize the evidence from previous observational studies and explore the potential association between DASH diet and breast cancer risk using meta-analysis.MethodsA comprehensive literature search was conducted using the databases of PubMed, Web of Science, CNKI and Wanfang Data to identify the relevant publications from inception up to July 2022. The pooled relative risks (RRs) and 95% confidence intervals (CIs) were calculated for the highest versus the lowest categories of DASH score in relation to breast cancer risk, using a random-effects model. The Cochran’s Q test and I-squared (I2) statistic were used to detect the sources of heterogeneity among the included studies.ResultsOverall, eleven studies, involving 23,254 breast cancer cases and 449,273 participants, were included in this systematic review and meta-analysis. Combining 16 effect sizes from 11 studies, a significant inverse association between adherence to the DASH diet and risk of breast cancer was observed (RR = 0.79; 95% CI: 0.70, 0.90, P < 0.0001). Stratified analysis showed a significant association between adherence to the DASH diet and risk of breast cancer in case-control studies (RR = 0.49; 95% CI: 0.27–0.89, P = 0.019), and a marginally significant association in prospective cohort studies (RR = 0.92; 95% CI: 0.86–0.98, P = 0.014), respectively. Besides, a more significant association between DASH score and reduced risk of breast cancer was observed in Asian countries (RR = 0.50; 95% CI: 0.31–0.81, P = 0.005) than in the United States (RR = 0.93; 95% CI: 0.89–0.99, P = 0.012). Similarly, when we conducted analyses separately by menopausal status, we found a significant inverse association between DASH diet and breast cancer risk in postmenopausal women (RR = 0.58; 95% CI: 0.39–0.87, P = 0.008).ConclusionThe results of this systematic review and meta-analysis indicate a significant inverse association between adherence to the DASH diet and risk of breast cancer. Further large prospective studies and randomized controlled trials are required to confirm our findings.

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“…In 2021, He et al [ 92 ]. performed a meta-analysis considering 36 articles with 1,019,232 participants including individuals of European and Asian populations.…”

Section: Epidemiological Evidencementioning

confidence: 99%

The Role of Cow’s Milk Consumption in Breast Cancer Initiation and Progression

et al. 2023

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Purpose of Review This review evaluates cow milk’s impact on breast carcinogenesis by linking recent epidemiological evidence and new insights into the molecular signaling of milk and its constituents in breast cancer (BCa) pathogenesis. Recent Findings Recent prospective cohort studies support the association between cow’s milk consumption and the risk of estrogen receptor-α-positive (ER+) BCa. Milk is a complex biological fluid that increases systemic insulin-like growth factor 1 (IGF-1), insulin and estrogen signaling, and interacting hormonal promoters of BCa. Further potential oncogenic components of commercial milk include exosomal microRNAs (miR-148a-3p, miR-21-5p), bovine meat and milk factors, aflatoxin M1, bisphenol A, pesticides, and micro- and nanoplastics. Individuals with BRCA1 loss-of-function mutations and FTO and IGF1 gain-of-function polymorphisms enhancing IGF-1/mTORC1 signaling may be at increased risk for milk-induced ER+ BCa. Summary Recent prospective epidemiological and pathobiochemical studies identify commercial milk consumption as a critical risk factor of ER+ BCa. Large meta-analyses gathering individuals of different ethnic origins with milk derived from dairy cows of varying genetic backgrounds and diverse feeding procedures as well as missing data on thermal processing of milk (pasteurization versus ultra-heat treatment) make multi-national meta-analyses unsuitable for BCa risk estimations in susceptible populations. Future studies are required that consider all vulnerable periods of breast carcinogenesis to cow’s milk exposure, beginning during the perinatal period and puberty, since these are the most critical periods of mammary gland morphogenesis. Notwithstanding the need for better studies including detailed information on milk processing and vulnerable periods of human breast carcinogenesis, the available evidence suggests that dietary guidelines on milk consumption may have to be reconsidered.

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The relationship between dairy products intake and breast cancer incidence: a meta-analysis of observational studies

Cited by 14 publications

References 125 publications

AGO Recommendations for the Diagnosis and Treatment of Patients with Early Breast Cancer: Update 2022

AGO Recommendations for the Diagnosis and Treatment of Patients with Early Breast Cancer: Update 2022

Adherence to the Dietary Approaches to Stop Hypertension diet reduces the risk of breast cancer: A systematic review and meta-analysis

The Role of Cow’s Milk Consumption in Breast Cancer Initiation and Progression

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