The relationship between circulating natural killer cells after reduced intensity conditioning hematopoietic stem cell transplantation and relapse-free survival and graft-versus-host disease

Dunbar, Erin; Buzzeo, Mathew P.; Levine, Jeffrey M.; Schold, Jesse D.; Meier-Kriesche, Herwig Ulf; Reddy, Vijay

doi:10.3324/haematol.13033

Cited by 54 publications

(45 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Some studies highlighted the ability of NK cells to exert potent anti-leukemic effects and to reduce relapse in patients after autologous or allogeneic SCT [2,20,28,29]. In the present study, NKA of patients increased after SCT compared with that before SCT; these patients achieved complete remission.…”

Section: Discussionsupporting

confidence: 59%

“…One study showed that, during the rst few months post-SCT, NK cells were the predominant circulating lymphoid cell subset with the potential to control disease relapse [2]. Another study demonstrated that a low absolute NK cell count at 60 days post-transplant was independently associated with relapse and death among patients receiving reduced intensity conditioning, and there was no signi cant association between the absolute NK cell count and graft-versus-host disease [28].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Variable Natural Killer Cell Activity in Hematological Malignancies at Diagnosis

et al. 2018

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 59%

Section: Discussionmentioning

confidence: 99%

Variable Natural Killer Cell Activity in Hematological Malignancies at Diagnosis

et al. 2018

View full text Add to dashboard Cite

show abstract

“…An expansion of CD56– NK cells may be common to different forms of HSCT, as CD56–/CD16+ NK cells has previously been described after cord blood transplantation [28], and after HLA-matched bone marrow/peripheral blood stem cell transplantation [29]. Little is known, however, about the function of CD56– NK cells arising after HSCT.…”

Section: Discussionmentioning

confidence: 97%

Expansion of CD56-Negative, CD16-Positive, KIR-Expressing Natural Killer Cells after T Cell-Depleted Haploidentical Hematopoietic Stem Cell Transplantation

et al. 2011

View full text Add to dashboard Cite

The main functions of natural killer (NK) cells are early protection against viruses or tumor cells and production of cytokines that regulate immune functions. The present study assessed the role of different NK subsets in exerting graft-versus-leukemia effects in recipients of human leukocyte antigen (HLA) haploidentical hematopoietic transplants and monitored for the first time CD3–/CD56– lymphocyte expansion. CD3–/CD56– cells expressed NK cell-associated molecules, such as CD16, NKp46, NKp30, CD244 (2B4), CD161, and killer cell immunoglobulin-like receptors. CD3–/CD56– cells further exhibited the classical functional characteristics of NK cells: cytolysis of target cells lacking HLA class I, antibody-dependent cellular cytotoxicity and cytokine production. These results demonstrate that CD56– NK cells are functional, recognize missing self and, like their CD56+ counterparts, may contribute to graft-versus-leukemia reactions.

show abstract

“…In contrast, the depletion of NK cells reduced the severity of the disease in a nonobese diabetic mouse model (7). Furthermore, NK cells have been reported to influence engraftment, graft-versus-host disease, and graft-versustumor effects in allogeneic hematopoietic stem cell transplantation (allo-SCT) (8)(9)(10)(11)(12), suggesting that NK cells are involved in the regulation of allogeneic tolerance and antitumor immunity.…”

Section: The Journal Of Immunologymentioning

confidence: 97%

The Rapid Induction of HLA-E Is Essential for the Survival of Antigen-Activated Naive CD4 T Cells from Attack by NK Cells

Takao

Ishikawa

Yamashita

et al. 2010

The Journal of Immunology

View full text Add to dashboard Cite

Increasing evidence shows that NK cells regulate adaptive immunity, but the underlying mechanisms are not well understood. In this study, we show that activated human NK cells suppress autologous naive CD4 T cell proliferation in response to allogeneic dendritic cells (DCs) by selectively killing Ag-activated T cells. Naive CD4 T cells, which were initially resistant to NK cell-mediated cytotoxicity, became substantially susceptible to NK cells within a day after priming with DCs. Ag-activated T cells showed various degrees of susceptibility to NK cells. After 1 d of priming with LPS-matured DCs, T cells were less susceptible to NK cells than were T cells primed with TNF-α–matured DCs. Subsequently at day 3, Ag-activated T cells regained resistance to NK cells. The level of HLA-E expression on Ag-activated T cells was closely correlated with resistance to NK cells. HLA-E was highly expressed at day 1 by T cells primed with LPS-matured DCs but not by T cells primed with TNF-α–matured DCs. An Ab blockade revealed a critical role for the HLA-E–NKG2A interaction in the protection of Ag-activated T cells from NK cells. Collectively, this study demonstrates that NK cells impact adaptive immunity through the finely controlled kinetics of HLA-E expression on T cells. Thus, HLA-E may be a new target for immunoregulation.

show abstract

The relationship between circulating natural killer cells after reduced intensity conditioning hematopoietic stem cell transplantation and relapse-free survival and graft-versus-host disease

Cited by 54 publications

References 30 publications

Variable Natural Killer Cell Activity in Hematological Malignancies at Diagnosis

Variable Natural Killer Cell Activity in Hematological Malignancies at Diagnosis

Expansion of CD56-Negative, CD16-Positive, KIR-Expressing Natural Killer Cells after T Cell-Depleted Haploidentical Hematopoietic Stem Cell Transplantation

The Rapid Induction of HLA-E Is Essential for the Survival of Antigen-Activated Naive CD4 T Cells from Attack by NK Cells

Contact Info

Product

Resources

About