The relationship between circulating adiponectin, leptin and vaspin with bone mineral density (BMD), arterial calcification and stiffness: a cross-sectional study in post-menopausal women

Tanna, Nuttan; Patel, Kishan; Moore, Amelia; Dulnoan, Dwight; Edwards, Sian; Hampson, Geeta

doi:10.1007/s40618-017-0711-1

Cited by 33 publications

(31 citation statements)

References 48 publications

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“…In the groups with BMD disorders, the number of patients who had calcinosis of two or more valves was significantly higher, and it was maximal in the group with osteoporosis. The studies of other authors also showed a link between calcification of the valves of the heart, coronary and peripheral arteries, and a decrease in BMD [13,[16][17][18], which can be explained by excessive activation of specific proteins (osteoprotegerin, osteocalcin), which leads not only to bone mineralization abnormalities, but also to the formation of ectopic calcification.…”

Section: Discussionmentioning

confidence: 99%

The interrelationship between the cardiovascular remodeling indicators and the state of bone mineral density in women with coronary artery disease

Mykhailovska

Stetsiuk

2019

Patologìâ

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A-research concept and design; B-collection and/or assembly of data; C-data analysis and interpretation; D-writing the article; E-critical revision of the article; F-final approval of the article Objective. To determine the peculiarities of the interrelationship between the cardiovascular remodeling indicators and the state of bone mineral density (BMD) in women with coronary artery disease (CAD). Methods. A double open cross-sectional monocentric clinical study in parallel groups involved 115 women in postmenopausal period with coronary artery disease (CAD): stable exertional angina of II-III functional class. Depending on the BMD state they were divided into 3 groups: group 1-24 patients with normal BMD; group 2-34 patients with osteopenia; group 3-44 patients with osteoporosis. The BMD state was assessed with the help of ultrasound densitometry combined with FRAX algorithm. The structural and functional parameters of the heart and blood vessels were determined using the two-dimensional echocardiography and pulsed-wave Doppler imaging. Results. It was established that in women with CAD there was a significant decrease in T-and Z-criteria and an increase in the 10-year risk of developing of osteoporosis fractures, depending on the severity of BMD loss. The presence of postmenopausal osteoporosis in women with coronary artery disease was associated with a significant increase in thickness of the intima-media complex of the right and left common carotid artery (by 14.94 % and 15.56 % respectively), LV PWd (by 9.26 %), and LV Myocardial stiffness index (by 40.00 %), decreased LV EF (by 8.77 %), development of the LV diastolic dysfunction by the type of the impaired relaxation (in 80.76 %), formation of predominantly concentric hypertrophy of LV (in 68.18 % of cases) and an increase in the incidence of LV eccentric hypertrophy compared to patients with normal BMD (11.36 % vs. 4.17 %; χ 2 = 4.267; df = 1; P < 0.05). In women with coronary artery disease and BMD abnormalities, the number of patients with heart valves calcification was significantly higher: 60.00 % in the group with osteopenia, 77.42 % in the group with osteoporosis in comparison with 28.58 % in the group with normal BMD; there was an increase in the incidence of calcinosis identification in two or more heart valves. The existence of a correlative dependence was established between T-and Z-criteria of the radial bone and LV EF (r = +0.42; P < 0.05), LV ESV (r = +0.61; P < 0.05), between Z-criteria of the radius, the 10-year risk of development of fractures of the radial bone and tibia and LAD (r = +0.43; P < 0.05; r = +0.50; P < 0.05 respectively), between the 10-year risk of the development of the tibial fractures and LVM (r = +0.58; P < 0.05). Conclusions. Changes in the structural and functional parameters of the heart in women with coronary artery disease progress depending on the severity of BMD loss, which indicates the interrelationship of bone and cardiovascular remodeling. Взаємозв'язок показників кардіоваскулярного ремоделювання зі станом мін...

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Section: Discussionmentioning

confidence: 99%

The interrelationship between the cardiovascular remodeling indicators and the state of bone mineral density in women with coronary artery disease

Mykhailovska

Stetsiuk

2019

Patologìâ

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“…Data on the association between serum leptin and AAC are scarce: a weak negative relation in 1 study, no link in others. 11,12 Those studies did not provide the prevalence of severe AAC. They analyzed AAC as present/absent, which is not specific enough to study its associations with other factors.…”

Section: Discussionmentioning

confidence: 99%

“…35 However, in our study HDL-C was not associated with AAC severity/progression (data not shown). Because the data on the link between HDL-C and vascular calcification are discordant, 10,12,15,22,23 the relationships between leptin, HDL and AAC need further study.…”

Section: Prospective Studymentioning

confidence: 99%

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Positive Association of High Leptin Level and Abdominal Aortic Calcification in Men　― The Prospective MINOS Study ―

Szulc

Amri

Varennes

et al. 2018

Circ J

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Background: Severe abdominal aortic calcification (AAC) points to high cardiovascular risk and leptin stimulates arterial calcification; however, clinical data on their association are scarce. We studied the link between serum leptin and AAC severity and progression, and the effect of smoking and lipid levels, on this association in men. Methods and Results: At baseline, 548 community-dwelling men aged 50-85 years underwent blood collection and lateral lumbar spine radiography. In 448 men, X-ray was repeated after 3 and 7.5 years. AAC was assessed using Kauppila's semiquantitative score. In multivariable models, high leptin was associated with higher odds of severe AAC (odds ratio [OR]=1.71 per SD, 95% confidence interval [CI]: 1.22-2.40). The odds of severe AAC were the highest in men who had elevated leptin levels and either were ever-smokers (OR=9.22, 95% CI: 3.43-24.78) or had hypertriglyceridemia (vs. men without these characteristics). Higher leptin was associated with greater AAC progression (OR=1.34 per SD, 95% CI: 1.04-1.74). The risk of AAC progression was the highest in men who had elevated leptin levels and either were current smokers or had high low-density lipoprotein-cholesterol levels (OR=5.91, 95% CI: 2.46-14.16 vs. men without these characteristics). These links remained significant after adjustment for baseline AAC and in subgroups defined according to smoking and low-density lipoprotein-cholesterol levels. Conclusions: In older men, high leptin levels are associated with greater severity and rapid progression of AAC independent of smoking, low-density lipoprotein-cholesterol or triglycerides.

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“…Moreover, the fact that many types of cytokines and peroxisome proliferator-activated receptor γ have effects on the differentiation and growth of the two cell types may explain the relationship [ 20 21 ]. Furthermore, it has been demonstrated that bone tissue formation is influenced by the fat-derived hormones leptin and adiponectin also via signals generated from adipose tissue [ 22 23 ], based on the presence of receptors for adipokines on both osteoblasts and osteoclasts [ 24 ]. Conversely, it has been found that bone tissue is involved in direct and indirect modulation of adipose tissue [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

Association between Bone Mineral Density and Albuminuria: Cross-Sectional Analysis of Data from the 2011 Korea National Health and Nutrition Examination Survey V-2

Kim

Lee

et al. 2018

Endocrinol Metab

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BackgroundAlbuminuria is known to be independently associated with progression of renal and cardiovascular disease. However, little is known regarding the exact relationship between albuminuria and bone mineral density (BMD). The aim of this population-based study conducted in Korea was to identify the association between albuminuria and BMD.MethodsWe performed a cross-sectional analysis of data from the Korea National Health and Nutrition Examination Survey (KNHANES V-2) 2011. BMD was measured for total hip (TH), femur neck (FN), and lumbar spine (LS). Analysis of covariance was used to compare BMD levels between the groups at the TH, FN, and LS sites, after adjusting for age. Separate analyses were performed according to sex; women were divided into two groups according to menopausal status and each group was subdivided into three according to urine albumin-to-creatinine ratio (level 1, <30 mg/g; level 2, 30 to 299 mg/g; level 3, ≥300 mg/g).ResultsData on a total of 1,831 adults (857 men and 974 women) were analyzed. In postmenopausal women, after adjusting for age, BMD of TH tended to decrease as levels of albuminuria increased (0.767±0.117, 0.757±0.129, 0.752±0.118, respectively; P=0.040). However, there was no significant difference in BMD according to albuminuria level in premenopausal women and men.ConclusionLevel of albuminuria was closely related with BMD of TH in postmenopausal women, after adjusting for age, but there was no significant relationship between albuminuria and BMD in premenopausal women and men.

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The relationship between circulating adiponectin, leptin and vaspin with bone mineral density (BMD), arterial calcification and stiffness: a cross-sectional study in post-menopausal women

Abstract: Adiponectin, leptin, vaspin are related to markers of bone and vascular health and may contribute to the observed association between osteoporosis and CVD.

Cited by 33 publications

References 48 publications

The interrelationship between the cardiovascular remodeling indicators and the state of bone mineral density in women with coronary artery disease

The interrelationship between the cardiovascular remodeling indicators and the state of bone mineral density in women with coronary artery disease

Positive Association of High Leptin Level and Abdominal Aortic Calcification in Men　― The Prospective MINOS Study ―

Association between Bone Mineral Density and Albuminuria: Cross-Sectional Analysis of Data from the 2011 Korea National Health and Nutrition Examination Survey V-2

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The relationship between circulating adiponectin, leptin and vaspin with bone mineral density (BMD), arterial calcification and stiffness: a cross-sectional study in post-menopausal women

Abstract: Adiponectin, leptin, vaspin are related to markers of bone and vascular health and may contribute to the observed association between osteoporosis and CVD.

Cited by 33 publications

References 48 publications

The interrelationship between the cardiovascular remodeling indicators and the state of bone mineral density in women with coronary artery disease

The interrelationship between the cardiovascular remodeling indicators and the state of bone mineral density in women with coronary artery disease

Positive Association of High Leptin Level and Abdominal Aortic Calcification in Men ― The Prospective MINOS Study ―

Association between Bone Mineral Density and Albuminuria: Cross-Sectional Analysis of Data from the 2011 Korea National Health and Nutrition Examination Survey V-2

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Positive Association of High Leptin Level and Abdominal Aortic Calcification in Men　― The Prospective MINOS Study ―