The interrelationship between the cardiovascular remodeling indicators and the state of bone mineral density in women with coronary artery disease

Mykhailovska, N. S.; Stetsiuk, I. O.

doi:10.14739/2310-1237.2019.1.166296

Cited by 4 publications

(5 citation statements)

References 8 publications

(10 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Thus, the obtained results confirm the existing scientific data on the presence of general pathogenetic bases of growth of bone and vascular remodeling biomarker levels, impaired osteogenesis and clinical features of coronary artery disease in postmenopausal women with CAD [11,16,31].…”

Section: Imc -Intima-media Complex La -Left Atrium LV -Left Ventricsupporting

confidence: 85%

“…Currently, there are only a few studies dedicated to the interrelation of coronary artery disease with bone mineral density (BMD) disorders. Existing literature provides information on only some aspects of this problem, firstly, regarding the prevalence and severity of vascular atherosclerosis and aortic calcification in patients with PMO [10,11].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The interrelationship of bone and cardiovascular remodeling biomarkers and clinical peculiarities of coronary artery disease in postmenopausal women

et al. 2020

View full text Add to dashboard Cite

Objectives: To investigate the interrelationship between bone and cardiovascular remodeling biomarkers and some clinical, laboratory and instrumental parameters of coronary artery disease in postmenopausal women. Material and methods: The double open cross-sectional monocentric clinical study in parallel groups involved 115 women in the postmenopausal period with coronary artery disease (CAD): stable exertional angina of functional class (FC) II-III (mean age 67.07 ±0.92 years). Depending on the bone mineral density (BMD) state, all patients were divided into 3 groups: group 1 (n = 24)-patients with normal BMD (T-criterion more than 1 SD); group 2 (n = 34)-patients with osteopenia (T-criterion from-1 SD to-2.5 SD); group 3 (n = 44)-patients with osteoporosis (T-criterion less than-2.5 SD). The selected control group consisted of 12 relatively healthy women of the corresponding age. All patients underwent cardiovascular and bone remodeling biomarkers' assessment, lipid profile tests, daily monitoring of ECG by Holter, two-dimensional echocardiography and pulsed-wave Doppler. Intima-media complex (IMC) measurement, ultrasound densitometry, and the FRAX algorithm were performed. Results: In women with coronary artery disease and postmenopausal osteoporosis (PMO), there was a significant increase in the level of bone osteoprotegerin (OPG), osteocalcin and vascular remodeling biomarkers (VEGF-A, homocysteine) in parallel with the progression of BMD disorders. The existence of a correlative dependence between osteoprotegerin level and the 10-year risk of fracture of the radial bone (r = 0.46; p < 0.05) was discovered. A probable interrelationship between the OPG, osteocalcin, VEGF-A and homocysteine level and decrease of the T-criterion was observed. An interrelationship between the bone and cardiovascular remodeling biomarkers and atherogenic dyslipidemia, diastolic dysfunction of the left ventricle, dilatation of the left atrium, thickening of the intima-media complex, arrhythmic complications and vegetative imbalance development was proved (p < 0.05), which confirms their clinical and pathogenic role in patients with CAD and PMO. Conclusions: The results obtained prove the existing interrelationship of bone and cardiovascular remodeling biomarkers with the state of bone mineral density and clinical peculiarities of coronary artery disease in postmenopausal women.

show abstract

Section: Imc -Intima-media Complex La -Left Atrium LV -Left Ventricsupporting

confidence: 85%

Section: Introductionmentioning

confidence: 99%

The interrelationship of bone and cardiovascular remodeling biomarkers and clinical peculiarities of coronary artery disease in postmenopausal women

et al. 2020

View full text Add to dashboard Cite

show abstract

“…The BMD state was assessed with the help of the ultrasound osteodensitometry on the Omnisense 7000 apparatus (Israel) according to the criteria specified in our previous works [13][14][15]. Electrical and ischemic parameters were investigated using Holter ECG daily moni toring with the use of a Cardiosens K instrument (KhAI MEDICA, Ukraine) according to the recommendations of the European Society of Cardiologists, and the Ukrainian Association of Cardiologists.…”

Section: Methodsmentioning

confidence: 99%

Vegetative and electrical disorders in women with chronic coronary syndrome depending on the state of bone mineral density

Mykhailovska¹,

Stetsiuk²

2022

Patologìâ

View full text Add to dashboard Cite

Aim: to determine the features of heart rate variability and electrical changes in the myocardium in women with chronic coronary syndrome, depending on the state of the bone mineral density (BMD). Materials and methods. 121 women with chronic coronary syndrome (CCS): stable exertional angina of II–III functional class (FC) (mean age 68.0 (60.0; 75.0) years) were examined and divided into 3 groups: group 1 − 30 women with ССS and normal BMD; group 2 – 33 women with CCS and osteopenia (OPе); group 3 – 58 women with CCS and osteoporosis (OP). All patients underwent daily ECG monitoring and ultrasound osteodensitometry. Results. In women with CCS and OP, increase in the frequency (by 2.9 times; P < 0.05) and duration (by 2.3 times; P < 0.05) of tachycardia episodes, the frequency of registration of ventricular and supraventricular extrasystole episodes (by 8.1 time and 1.2 times, respectively; P < 0.05) if compared to patients without BMD disorders was found. In women with СCS and OPе there was a tendency to increase in these indicators, which did not reach the level of statistical significance. The presence of BMD disorders in patients with CCS was accompanied with decrease in total HRV activity (RMSSD and HRVT), the development of the predominance of ANS sympathetic domain activity, as evidenced by an increase in LF by 44.3 % at the daytime and 44.0 % at night, decrease in HF 2.3 times during the day and 2.1 times at night in patients with OPe and OP, respectively. According to the correlation analysis data, the presence of correlations between the state of BMD and indicators of electrical and autonomic activity of the myocardium was established. Conclusions. In postmenopausal women with CCS, the severity of autonomic and electrical disorders is associated with the degree of bone disorders and is maximal in osteoporosis.

show abstract

“…Хронічний коронарний синдром (ХКС)найважливіша проблема сучасної кардіології як в світі, так і в Україні, зокрема, через значну поширеність та негативні наслідки [4,11]. Тому актуальним є дослідження впливу супутніх захворювань на перебіг ІХС з метою пошуку патогенетичних взаємозв'язків коморбідної патології [14,20] Поряд із ХКС важливою медико-соціальною проблемою є захворювання шлунково-кишкового тракту [2. 23], серед них важлива роль відводиться патології печінки.…”

Section: вступunclassified

Predictor value of neurohumoral disorders in patients with chronic coronary syndrome with concomitant non-alcoholic fat disease

Mykhailovska¹,

Miniailenko²,

Lisova³

et al. 2021

Rep. of Vinnytsia Nation. Med. Univ.

Self Cite

View full text Add to dashboard Cite

Annotation. Today it is important to study the clinical and prognostic role of neurohumoral disorders in patients with stable forms of chronic coronary syndrome (CCS) and concomitant liver pathology. The aim of the study: to investigate the levels of markers of insulin, adipokine balance, systemic inflammation and endothelial dysfunction and their predictor value for the presence of non-alcoholic fatty liver disease (NAFLD) in patients with CCS. The prospective monocenter double open study in parallel groups involved 120 patients with CCS: stable angina pectoris II-III functional class aged 60.0 (55.0; 64.0) years, of whom 67 (55%) men and 53 (45 %) women. The control selected group included 30 healthy individuals aged 59.0 (58.0; 66.0) years, including 14 (46%) men and 16 (54%) women. Determination of the serum concentration of biomarkers (adiponectin, resistin, insulin, asymmetric dimethylarginine (ADMA), C-reactive protein) was performed using enzyme-linked immunosorbent assay. Statistical data processing was performed using the license program package “Statistica 13.0” (StatSoftInc, USA, № JPZ8041382130ARCN10-J). The hypothesis about the normality of the distribution of the studied indicators was tested using the Shapiro-Wilk test. Quantitative traits were presented as M ± m or Me (Q25; Q75), depending on the type of distribution. Significance of differences was assessed using Student's t-test (for normal distribution) or Mann-Whitney U-test for independent samples (for distribution other than normal). In order to establish the threshold values of biomarkers for predicting the presence of NAFLD ROC analysis was used. It was found that in patients with CCS with concomitant NAFLD, compared with patients with CCS without liver pathology, there is a significant (p <0,05) increase in insulin levels, HOMA index, resistin, ADMA, RF-C-reactive protein and a decrease in adiponectin concentration. According to the results of ROC analysis, it was found that ADMA (Se = 80.0; Sp = 82.9; AUC = 0.91) had a high sensitivity, the optimal ratio of sensitivity and specificity for the diagnosis of NAFLD among all studied biomarkers. Other biomarkers (HOMA index, adiponectin, resistin, adiponectin/resistin ratio) also had an AUC greater than 0.8, but smaller sensitivity/specificity ratio. Thus, in patients with CCS associated with NAFLD, compared with patients without NAFLD, an imbalance of adipocytokines on the background of insulin resistance, systemic inflammation and endothelial dysfunction is observed. Asymmetric dimethylarginine has the highest sensitivity, the optimal ratio of sensitivity and specificity for the diagnosis of NAFLD in patients with coronary artery disease.

show abstract

The interrelationship between the cardiovascular remodeling indicators and the state of bone mineral density in women with coronary artery disease

Cited by 4 publications

References 8 publications

The interrelationship of bone and cardiovascular remodeling biomarkers and clinical peculiarities of coronary artery disease in postmenopausal women

The interrelationship of bone and cardiovascular remodeling biomarkers and clinical peculiarities of coronary artery disease in postmenopausal women

Vegetative and electrical disorders in women with chronic coronary syndrome depending on the state of bone mineral density

Predictor value of neurohumoral disorders in patients with chronic coronary syndrome with concomitant non-alcoholic fat disease

Contact Info

Product

Resources

About