The relationship between central corneal thickness and the optic disc in an elderly population: the Bridlington Eye Assessment Project

Abstract

Purpose To determine population-based normative CCT data for elderly white subjects, with and without diabetes, and to explore the relationship between CCT and IOP and HRT2 measurements in such subjects with normal visual fields. Methods All eligible subjects were consecutive in a population screened for eye disease. CCT was measured by ultrasound pachymetry, and the optic disc was morphometrically defined using Heidelberg retinal tomography (HRT2). Inclusion criteria were: (1) normal visual field on suprathreshold testing and (2) corrected logMAR acuity of at least 0.3 in both eyes. Subjects with significant corneal pathology, previous corneal surgery, or known history of glaucoma or treatment for raised intraocular pressure were excluded. One eye was randomly selected from each subject for analysis. Results In all, 983 eyes of 983 subjects were included with 690 HRT images deemed acceptable for the analysis. The mean age (414 men and 569 women) was 73.3 years (minimum 65 years). Mean (SD) CCT was 544.1 (36.5) lm, with a normally distributed range of 429-633 lm. There was no significant difference in CCT between men and women (mean CCT 546.1 and 542.7 lm, respectively, P ¼ 0.15, Student's t-test), though CCT was correlated weakly and negatively with age (Pearson's r ¼ À0.063, P ¼ 0.047). Diabetic patients (n ¼ 103) had a greater mean CCT than non-diabetic patients (551.9 and 543.0 lm respectively, P ¼ 0.02). No significant correlation was found between any global optic disc parameter and CCT in the 690 eyes analysed. Conclusion Elderly white eyes with normal fields have CCTs that are normally distributed, with those from diabetic persons having greater CCTs. No clear evidence of a relationship between CCT and HRT2 optic disc parameters used in glaucoma diagnosis was found.

Optic Disk Size Variability Between African, Asian, White, Hispanic, and Filipino Americans Using Heidelberg Retinal Tomography

“…The two variables had a positive, although small relationship. Some studies have suggested that CCT may vary with optic disk size in all eyes or those with POAG29, 36 while other, larger studies evaluating CCT and optic disk size have suggested no relationship31, 37. Our multivariate analysis revealed no relationship between CCT and Global Disk Area in our population when correcting for diagnosis, or in the POAG group alone.…”

The Heidelberg retina tomograph ancillary study to the European glaucoma prevention study: study design and baseline factors

“…None of these associations remained significant after adjusting for age, HRT disc size and IOP (Table 5). This is consistent with the results of a population-based study on normal individuals Hawker et al (2009).…”

The thick and thin of the central corneal thickness in glaucoma

“…Similarly, the Tajimi study in Japan found a thinner CCT associated with a larger cup volume [58]. However, in other population-based studies there was no significant relationship with any optic disc parameter [15,59]. Some hospital-based studies have found CCT associated with optic disc area [60][61][62], nasal rim area [63], as well as no significant correlation of CCT and disc size [62].…”