The relationship between cd5‐expressing b lymphocytes and serologic abnormalities in rheumatoid arthritis patients and their relatives

Youinou, Pierre; Mackenzie, Lorna; Katsikis, Peter D.; Merdrignac, G.; Isenberg, David; Tuaillon, Nadine; Lamour, A.; Goff, P. Le; Jouquan, Jean; Drogou, A.; Muller, Sylviane; Genetet, B; Moutsopoulos, H. M.; Lydyard, Peter M.

doi:10.1002/art.1780330306

Cited by 63 publications

(25 citation statements)

References 42 publications

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“…These 4C8-secreting cells were reported to have the surface phenotype of B1 cells (31,32). B1 cells have been observed in elevated numbers in patients with the autoimmune diseases Sjogren's syndrome and rheumatoid arthritis, suggestive that these cells may have some role to play in the pathogenicity of certain autoimmune diseases (33,34).…”

Section: Discussionmentioning

confidence: 98%

Different Kinetics of Blimp-1 Induction in B Cell Subsets Revealed by Reporter Gene

Fairfax

Corcoran

Pridans

et al. 2007

The Journal of Immunology

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The transcriptional repressor Blimp-1 (B lymphocyte-induced maturation protein 1) has been described as a “master regulator” of B cell differentiation into Ab-secreting cells (ASCs). Although there is mounting evidence for the importance and necessity of Blimp-1 in plasma cell development, there is uncertainty as to the role it plays in B cell differentiation of B cell subsets and the way in which it may interact with other transcription factors such as Pax5 and Bcl6 during ASC differentiation. Using a mouse expressing GFP under the control of the Blimp-1 regulatory elements (Blimp-1GFP/+), we examined the kinetics of Blimp-1 up-regulation in purified B cell subsets following activation. B1 cells showed the most rapid and pronounced up-regulation of Blimp-1 in response to the mitogens tested, followed by marginal zone B cells and then conventional B2 cells. Interestingly, only B1 cells substantially up-regulated Blimp-1 expression in response to CpG. B1 cells secreted negligible Ig upon isolation but were able to up-regulate Blimp-1 and initiate Ig secretion within 28 h of stimulation. Also of interest, B1 cells have a transcriptional factor profile that is intermediate between a naive B cell and an ASC, indicative of the semiactivated state of B1 cells. Transferred naive Blimp-1GFP/+ B1 and B2 cells both gave rise to ASCs in the bone marrow, suggesting no intrinsic barriers to B1 cell entry into the long-lived ASC compartment.

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Section: Discussionmentioning

confidence: 98%

Different Kinetics of Blimp-1 Induction in B Cell Subsets Revealed by Reporter Gene

Fairfax

Corcoran

Pridans

et al. 2007

The Journal of Immunology

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“…These selfantigen-reactive antibodies may bind to their own components, initiate an inflammatory response, and contribute to the pathogenesis of various autoimmune disorders. Indeed, elevated numbers of CD5 ϩ B-1 cells producing a variety of self-reactive antibodies have been reported in patients suffering from Sjögren's syndrome (11) and rheumatoid arthritis (42). Also, the close association of H. pylori infection with several autoimmune diseases such as rheumatoid arthritis (22), Sjögren's syndrome (12), and ITP (17), has been shown.…”

Section: Discussionmentioning

confidence: 99%

Implications for Induction of Autoimmunity via Activation of B-1 Cells byHelicobacter pyloriUrease

Yamanishi

Iizumi²,

Watanabe³

et al. 2006

Infect Immun

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“…In addition to CD22 and CD19, the size of the B-1a cell pool appears to be under genetic regulation. It has indeed been established that twins have the same levels of B-1a [105], and that the relatives of patients with RA offer a similar frequency of B-1a cells as the proband [106].…”

Section: Role Of Polymorphism In Signalling Molecules In Determining mentioning

confidence: 99%

Recent Progress in the Understanding of B‐Cell Functions in Autoimmunity

Porakishvili

Mageed

Jamin³

et al. 2001

Scand J Immunol

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54:30±38Our early concepts of the normal role of B cells in immunity focused on their ability to produce antibodies (Ab) and in the case of autoimmune diseases autoAbs, some of which were pathogenic. Over the past 10 years, it has became apparent that B cells display a variety of characteristics, other than Ab production, which could contribute to autoimmunity. They normally play a role in the development of lymphoid architecture, regulating T-cell subsets and dendritic cell (DC) function through cytokine production, and in activation of T cells. Receptors editing is also important in B cells which aids in immunity to infection and, possibly, prevention of autoimmunity. Transgenic animal models have now shown that B cells are necessary for many autoimmune diseases although their Ab products are not required in some cases. Negative signalling by CD5 and other molecules, such as CD22, in maintaining tolerance through recruitment of src-homology two domaincontaining protein tyrosine phosphatase-1 has also been documented. In fact, we have now reached a new era whereby the B cell has returned as an important contributor to autoimmune disorders, so that the race is on to characterize signalling regulation via the B-cell receptor and coreceptors. Identification of such molecules and their potential defects should lead to effective ways of controlling the immune response and in particular preventing the development of autoimmune states. The classical view of B cells in the biology of immune responses to infectious and self-antigens (Ag) that they promote immunity primarily by producing Ab turns out to be rather naõ Ève. Indeed, studies over the last few years indicate that this view is far from complete, and suggest that B lymphocytes have extraordinarily diverse functions within the immune system. Furthermore, it is becoming increasingly clear that the pathogenesis of autoimmune diseases cannot solely be accounted for by T cells, and intrinsic abnormalities of B cells have been described in such conditions. In this brief review we highlight some recent observations in the context of B lymphocyte in pathophysiology, and focus on their revival as pivotal players the pathophysiology in autoimmune diseases. Yet, it remains difficult to provide a model of how important B cells are in immunity and autoimmunity.

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The relationship between cd5‐expressing b lymphocytes and serologic abnormalities in rheumatoid arthritis patients and their relatives

Abstract: The influence of genetic factors on the expression of CD5+ B lymphocytes and their relationship to a broad spectrum of autoantibodies was investigated in a study of 12 patients with rheumatoid arthritis (RA) and 52 of their healthy first-degree relatives.

Cited by 63 publications

References 42 publications

Different Kinetics of Blimp-1 Induction in B Cell Subsets Revealed by Reporter Gene

Different Kinetics of Blimp-1 Induction in B Cell Subsets Revealed by Reporter Gene

Implications for Induction of Autoimmunity via Activation of B-1 Cells byHelicobacter pyloriUrease

Recent Progress in the Understanding of B‐Cell Functions in Autoimmunity

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