Implications for Induction of Autoimmunity via Activation of B-1 Cells by<i>Helicobacter pylori</i>Urease

Yamanishi, Shingo; Iizumi, Tadasu; Watanabe, Eri; Shimizu, Mitsuru; Kamiya, Shigeru; Nagata, Kumiko; Kumagai, Yoshihiro; Fukunaga, Yoshitaka; Takahashi, Hidemi

doi:10.1128/iai.74.1.248-256.2006

Cited by 94 publications

(72 citation statements)

References 42 publications

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“…In the most recent study, it was concluded that there is generally a negative relationship of various infectious agents, including H. Pylori, in the development of SLE [11]. In an animal study, H. Pylori exposed to urease enzyme was found to lead to the formation of anti-ssDNA antibodies [12]. Generally, the existing evidence does not support that H. Pylori has a role in the development of SLE [13].…”

Section: H Pylorı and Slementioning

confidence: 98%

The Relationship of Systemic Lupus Erythematosus and Helicobacter Pylori

Yıldırım¹,

Yıldırım²

2015

Med-Science

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Systemic lupus erythematosus (SLE) is an inflammatory disease of unknown etiology. In the pathogenesis of SLE, several infectious agents have been held responsible such as cytomegalovirus, parvovirus B19 and Epstein Barr virus (EBV). There is a variable relationship between SLE and helicobacter, which is different from that of lupus and other infections. We would like to emphasize the interrelation between these entities.

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Section: H Pylorı and Slementioning

confidence: 98%

The Relationship of Systemic Lupus Erythematosus and Helicobacter Pylori

Yıldırım¹,

Yıldırım²

2015

Med-Science

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“…This hypothesis may explain the observed variability in treatment effect by country since CagA-positive strains of H. pylori are more prevalent in Japan than in North America. 28 Other proposed mechanisms are modulation of host immunity following colonization by H. pylori to favor the emergence of autoreactive B-1 cells 29 and the enhancement of phagocytic capacity of monocytes together with low levels of the inhibitory Fcγ receptor IIB following H. pylori infection. 30 Our findings raise questions that merit further research.…”

Section: Discussionmentioning

confidence: 99%

Platelet count response to H. pylori treatment in patients with immune thrombocytopenic purpura with and without H. pylori infection: a systematic review

Arnold¹,

Bernotas²,

Nazi³

et al. 2009

Haematologica

122

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Eradication of H. pylori improves thrombocytopenia in some patients with immune thrombocytopenic purpura by mechanisms that remain obscure. Platelet count responses may occur independently of H. pylori infection as a result of the immune modulating effects of macrolide antimicrobials or the removal of other commensal bacteria. We performed a systematic review of the literature to determine the effect of H. pylori eradication therapy in patients with immune thrombocytopenic purpura by comparing the platelet response in patients who were, and who were not infected with H. pylori. MEDLINE, EMBASE, Cochrane central registry and abstracts from the American Society of Hematology (from 2003) were searched in duplicate and independently without language or age restrictions. Eleven studies, 8 from Japan, were included enrolling 282 patients with immune thrombocytopenic purpura who received eradication therapy; 205 were H. pylori-positive and 77 were H. pylori-negative. The odds of achieving a platelet count response following eradication therapy were 14.5 higher (95% confidence interval 4.2 to 83.0) in patients with H. pylori infection (51.2% vs. 8.8%). No study reported bleeding or quality of life. Adverse events were reported in 12 patients. H. pylori eradication therapy was of little benefit for H. pylori-negative patients. These findings strengthen the causal association between H. pylori infection and immune thrombocytopenia in some patients. Randomized trials are needed to determine the applicability of H. pylori eradication therapy across diverse geographical regions.Key words: helicobacter, autoimmunity, purpura, platelets. Citation

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“…In an animal study, it was found that exposure to H.pylori urease can lead to production of anti-single stranded DNA antibodies [39]. Kalabay and colleagues studied the prevalence of anti-H.pylori antibodies in various autoimmune rheumatic diseases and they found the comparable prevalence of H.pylori in SLE patients and healthy controls [40].…”

Section: Discussionmentioning

confidence: 99%

Association of Helicobacter pylori Infection with Systemic Lupus Erythematosus

Ejtehadi¹,

Roghanian²,

Bonakdar³

2017

J Clin Cell Immunol

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Objective: Systemic Lupus Erythematosus (SLE) is an autoimmune disease of unknown etiology. However, a complex combination of host and environmental factors are believed to play a pivotal role. In the pathogenesis of SLE, several infectious agents have been held responsible such as Cytomegalovirus, Parvovirus B19, Epstein Barr virus and Retrovirus. There is a variable relationship between SLE and Helicobacter, which is different from that of lupus and other infections. The aim of this study was to investigate the association between Helicobacter pylori (H.pylori) infection and SLE development. Method:In this study, 82 serum samples and 65 stool samples were collected from the SLE patients as well as the control group, respectively. An enzyme-linked immunosorbent assay (ELISA) was used to detect the presence of specific IgG/IgM antibodies against H.pylori in all serum samples. The presence of H.pylori antigen was examined in all stool samples by using stool antigen test. Suitable statistical analysis was applied.Results: Thirteen (15.9%) out of 82 SLE patients and 30 (36.6%) out of 82 control group were anti-H.pylori IgM seropositive. There was a significant difference between the level of IgM in SLE patients and control group (p<0.05). Anti-H.pylori IgG antibodies were present in 37 (45.1%) of SLE patients and in 41 (50%) of the control group without any significant difference. Regarding stool antigen examination, there were 24 (36.9%) and 26 (42/6%) positive samples among the SLE patients and control group, respectively. There was no significant difference between the patients and controls samples in the number of stool antigen test positive samples (p>0.05). Conclusions:Based on data obtained in this study, it is concluded that there was a significant difference between the number of IgM seropositive in SLE patients and control group, which shows that SLE disease may have an inhibitory role in H.pylori infection occurance.

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Implications for Induction of Autoimmunity via Activation of B-1 Cells byHelicobacter pyloriUrease

Abstract: Besides various gastroduodenal diseases,

Cited by 94 publications

References 42 publications

The Relationship of Systemic Lupus Erythematosus and Helicobacter Pylori

The Relationship of Systemic Lupus Erythematosus and Helicobacter Pylori

Platelet count response to H. pylori treatment in patients with immune thrombocytopenic purpura with and without H. pylori infection: a systematic review

Association of Helicobacter pylori Infection with Systemic Lupus Erythematosus

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