The relationship between C‐reactive protein rs3091244 polymorphism and ankylosing spondylitis

Akbal, Ayla; Reşorlu, Hatice; Gökmen, Ferhat; Savaş, Yılmaz; Zateri, Çoşkun; Sargın, Betül; Bozkurt, Emre; Sılan, Fatma; Özdemir, Öztürk

doi:10.1111/1756-185x.12619

Cited by 5 publications

(7 citation statements)

References 22 publications

(35 reference statements)

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“…Recently, two Caucasian studies have addressed the association between CRP gene rs3091244 polymorphism and AS risk 19,20 and both showed that CRP gene rs3091244 polymorphism was associated with an increased risk of AS, which was in line with our findings. This present study demonstrated that AA+GA or AA genotype was associated with an increased risk of AS.…”

Section: Discussionsupporting

confidence: 90%

“…12 Moreover, SNPs of some genes could predict treatment response to etanercept in AS patients. Recently, two Caucasian studies have addressed the association between CRP gene rs3091244 polymorphism and AS risk 19,20 and both showed that CRP gene rs3091244 polymorphism was associated with an increased risk of AS, which was in line with our…”

Section: Association Of Crp Gene Rs3091244 Polymorphism With the Sesupporting

confidence: 83%

“…However, whether CRP gene rs3091244 polymorphism affects the therapeutic effect of etanercept in AS patients is unsolved. In addition, the association between CRP gene rs3091244 polymorphism and AS risk was explored in Caucasian populations, 19,20 but no Chinese studies addressed this issue. For the above reasons, we designed this case-control study to assess the association between CRP gene rs3091244 polymorphism and AS risk, and the efficacy of etanercept treatment for AS patients in a Chinese Han population.…”

Section: Introductionmentioning

confidence: 99%

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Association between C‐reactive protein gene variant and treatment efficacy of etanercept in ankylosing spondylitis patients receiving hip arthroplasty

Jiang

Zhang

2020

Clinical Laboratory Analysis

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Background C‐reactive protein (CRP) level is one of the most widely used parameters to assess ankylosing spondylitis (AS), since CRP is associated with poor radiographic progression of AS patients. Recent studies have investigated the association between CRP gene variants and AS risk, but with conflicting findings. Material and Methods We enrolled 232 AS cases and 314 controls in this case‐control study. Next, we assessed the association of CRP gene rs3091244 polymorphism with the efficacy of etanercept for AS. Genotyping was done using a custom‐by‐design 48‐Plex SNP scanTM Kit. Results CRP gene rs3091244 polymorphism was associated with an increased risk of AS in this Chinese population. Clinical indicators of AS patients including morning stiffness time, Bath AS function index (BASFI), Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Visual Analogue Scale (VAS), erythrocyte sedimentation rate (ESR), and CRP were significantly decreased after 12 weeks of etanercept treatment. Furthermore, AA genotype carriers showed higher values of VAS, BASDAI, BASFI, and CRP before etanercept treatment. AA genotype or A allele of rs3091244 polymorphism was associated with Ankylosing Spondylitis Assessment Study group response criteria 20 scores (ASAS20) and Assessment in SpondyloArthritis international Society 40 response (ASAS40) improvement. In addition, AA genotype carriers showed significantly higher CRP levels compared with genotype GG carriers (16.3 vs 8.8 mg/L). Conclusion CRP gene rs3091244 polymorphism is associated with an increased risk of AS. Additionally, rs3091244 polymorphism could serve as a biomarker for good response to etanercept treatment in AS.

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Section: Discussionsupporting

confidence: 90%

Section: Association Of Crp Gene Rs3091244 Polymorphism With the Sesupporting

confidence: 83%

Section: Introductionmentioning

confidence: 99%

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Association between C‐reactive protein gene variant and treatment efficacy of etanercept in ankylosing spondylitis patients receiving hip arthroplasty

Jiang

Zhang

2020

Clinical Laboratory Analysis

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“…we found that AS patients with CT genotype on rs6693831 have higher CRP levels ( P = 0.022), which brings up a hint that this SNP may relate to the expression or regulation of CRP among AS patients. Previous studies have demonstrated that CRP polymorphisms could influence serum CRP levels and the disease activity in AS, and polymorphism on rs3091244 can also affect CRP levels [ 35 ]. These facts suggest that there may exist mutual SNPs, which influence both the IL-23 and CRP at the same time.…”

Section: Discussionmentioning

confidence: 99%

IL-23R and IL-17A polymorphisms correlate with susceptibility of ankylosing spondylitis in a Southwest Chinese population

Yang

Liu

et al. 2017

Oncotarget

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The association between the IL-23R and IL-17A polymorphisms and ankylosing spondylitis (AS) in the Southwest Chinese Population is still unclear. The purpose of this study is to detect the association between IL-23R and IL-17A polymorphisms and AS. A case–control study consisting of 486 AS patients and 480 healthy controls was performed. We used the high-resolution melting methods (HRM) to genotype five selected single nucleotide polymorphisms (SNPs), rs6693831, rs7517847, rs1884444, rs10889677 in the IL-23R gene and rs2275913 in the IL-17A gene. Meanwhile, the laboratory indexes were recorded. In this study, patients with genotype CC (p = 8.574E-8) and allele C (p = 3.206E-31) on SNP rs6693831 (IL-23R) showed decreased risk of AS. The genotype TT (p = 4.551E-6) and allele T (p = 0.02) on SNP rs1884444 (IL-23R) showed significant lower risk of AS. Individuals carrying the allele A of rs2275913 showed higher morbidity of AS (p = 0.04). We first detected that rs6693831 and rs1884444 in IL-23R gene and rs2275913 in IL-17A gene have genetic association with AS.

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“…В наших исследованиях, проведенных ранее, отмечалась связь повышенных уровней СРБ с фенотипами системной склеродермии: диффузной формой, длительностью дебюта, серопозитивностью по антителам к топоизомеразе 1 и генетическими вариантами полиморфизма rs1205 С/Т гена CRP [17]. Высокий риск развития АС был показан у носителей генотипа СС другого полиморфизма rs3091244 C/T гена CRP [18].…”

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Involvement of polymorphisms of TNF, CRP and SAA1 genes in the predisposition to the development of ankylosing spondylitis and its clinical manifestations

Krylov¹,

Гусева²,

Sakharova³

et al. 2022

Naučno-praktičeskaâ revmatologiâ

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Objective. To study the involvement of the rs1800629 G/A polymorphisms of the TNF-α gene, rs1205C/T of the CRP gene, and rs12218T/C of the SAA1 gene in the predisposition to ankylosing spondylitis (AS) and their role in the formation of clinical phenotypes of AS.Materials and methods. 122 patients with AS were included in the study. All patients had a diagnosis of AS based on the modified New York criteria. The presence of the HLA-B27 antigen was detected in 109 (89.3%) patients, the presence of peripheral arthritis – in 71 (58.2%), enthesitis – in 92 (75.4%), coxitis – in 82 (67.2%) patients. All patients had a high degree of activity with an average BASDAI index of 5.6±1.2. The control group consisted of 142 healthy blood donors. Polymorphisms were studied using allele-specific real-time polymerase chain reaction (RT-PCR).Results. Significant differences were found in the frequencies of genotypes and alleles of the -308G/A polymorphism of the TNF gene and the frequencies of alleles of the rs12218 T/C polymorphism of the SAA1 gene between patients and the control group (p=0.01, p=0.01 and p=0.03 respectively). Logistic regression analysis showed that the presence of at least one -308A allele in the patient’s genotype reduced the risk of developing AS by 4.4 times compared with the GG genotype (p=0.006). In carriers of the GA genotype, the probability of a predisposition to the development of enthesitis was 2.2 times lower than in carriers of the GG genotype (p=0.01). The relationship between the rs1205 polymorphism of the CRP gene and the predisposition to peripheral arthritis has been established. Carriage of the rs1205T allele doubled the susceptibility to arthritis compared with the rs1205C allele (p=0.013). Carriage of at least one rs12218C allele of the SAA1 gene doubled the susceptibility to AS (p=0.018).Conclusion. The data obtained confirm the involvement of polymorphisms rs1800629 of the TNF gene, rs1205 of the CRP gene, and rs12218 of the SAA1 gene in the predisposition to AS. TNF gene polymorphism is associated with the formation of the clinical phenotype of enthesitis, and CRP gene polymorphism is associated with a predisposition to peripheral arthritis.

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The relationship between C‐reactive protein rs3091244 polymorphism and ankylosing spondylitis

Abstract: The presence of the CRP gene CC wild haploid and C allele in patients may indicate an increased risk for AS.

Cited by 5 publications

References 22 publications

Association between C‐reactive protein gene variant and treatment efficacy of etanercept in ankylosing spondylitis patients receiving hip arthroplasty

Association between C‐reactive protein gene variant and treatment efficacy of etanercept in ankylosing spondylitis patients receiving hip arthroplasty

IL-23R and IL-17A polymorphisms correlate with susceptibility of ankylosing spondylitis in a Southwest Chinese population

Involvement of polymorphisms of TNF, CRP and SAA1 genes in the predisposition to the development of ankylosing spondylitis and its clinical manifestations

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