IL-23R and IL-17A polymorphisms correlate with susceptibility of ankylosing spondylitis in a Southwest Chinese population

Yang, Bin; Xu, Yuanwei; Liu, Xinle; Huang, Zhuochun; Wang, Lanlan

doi:10.18632/oncotarget.20319

Cited by 16 publications

(13 citation statements)

References 36 publications

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“…Single nucleotide polymorphisms identified in the IL-17 signalling pathway that have been linked to axial spondyloarthritis and psoriatic arthritis. a Significant association shown in European but not Asian populations204; b No risk associated with this SNP shown in certain studies204–206; c No risk associated with this SNP shown in certain studies207; d SNP can be associated with risk or protection depending on the specific mutation. AS, ankylosing spondylitis; IL-1R2, interleukin 1 receptor; IL-6R, interleukin 6 receptor; IL17R, interleukin receptors; PsA, psoriatic arthritis; SNP, single nucleotide polymorphism.…”

Section: Role Of Il-17a In Spamentioning

confidence: 99%

The role of IL-17A in axial spondyloarthritis and psoriatic arthritis: recent advances and controversies

et al. 2019

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Although the pathogenic mechanisms underlying axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA) are not fully elucidated, several lines of evidence suggest that immune responses mediated by interleukin 17A (IL-17A) play a pivotal role in both diseases. This is best highlighted by the significant clinical efficacy shown with inhibitors of IL-17A in treating axSpA and PsA. Nevertheless, a number of knowledge gaps exist regarding the role of IL-17A in the pathophysiology of spondyloarthritis in man, including its cellular origin, its precise role in discrete disease processes such enthesitis, bone erosion, and bone formation, and the reasons for the discrepant responses to IL-17A inhibition observed in certain other spondyloarthritis manifestations. In this review, we focus on the latest data from studies investigating the role of IL-17A in ankylosing spondylitis (AS) and PsA that build on existing and emerging scientific knowledge in the field. Key remaining research questions are also highlighted to guide future research.

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Section: Role Of Il-17a In Spamentioning

confidence: 99%

The role of IL-17A in axial spondyloarthritis and psoriatic arthritis: recent advances and controversies

et al. 2019

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“…Three single nucleotide polymorphisms (SNPs) in genes that encode inflammatory cytokines have been associated with AS, in a previous study by our research group ( TNF rs1800629, IL17A rs2275913, and IL17F rs763780) ( 6 ). These polymorphisms can interfere with the level of production of these cytokines and contribute to the development of AS ( 7 – 10 ).…”

Section: Introductionmentioning

confidence: 99%

Influence of IL10 (rs1800896) Polymorphism and TNF-α, IL-10, IL-17A, and IL-17F Serum Levels in Ankylosing Spondylitis

et al. 2021

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Ankylosing spondylitis (AS) is a chronic autoimmune inflammatory disease that mainly affects the axial and sacroiliac joints. Single-nucleotide polymorphisms (SNPs) in genes encoding cytokines have been associated with AS, which can interfere with the production of these cytokines and contribute to the development of AS. In order to contribute to a better understanding of the pathology of AS, our objective was to investigate a possible association of the IL10 −1082 A>G SNP (rs1800896) with AS and to evaluate the serum levels of TNF-α, IL-10, IL-17A, and IL-17F in AS patients and controls comparing them with their respective genotypes (TNF rs1800629, IL10 rs1800896, IL17A rs2275913, and IL17F rs763780). Patients and controls were selected from the Maringá University Hospital and the Maringá Rheumatism Clinic, in Paraná State, Southern Brazil, and they were diagnosed by the ASAS Criteria. In total, 149 patients and 169 controls were genotyped for the IL10 −1082 A>G polymorphism using a polymerase chain reaction with sequence specific primers (PCR-SSP); the measurement of TNF-α serum levels was performed through the immunofluorimetric test and IL-10, IL-17A, and IL-17F using an ELISA test. There was a high frequency of the IL10 −1082 G allele in AS patients compared with controls with an odds ratio of 1.83 and 95% confidence interval of 1.32 to 2.54, and a significant difference in the genotype frequencies of the IL10 −1082 A/G+G/G between patients and healthy controls, with an odds ratio of 3.01 and 95% confidence interval of 1.75 to 5.17. In addition, increased serum levels of IL-10 were observed in AS patients: 2.38 (IQR, 0.91) pg/ml compared with controls 1.72 (IQR 0.93) pg/ml (P = 0.01). Our results also showed an association between IL17F rs763780 C/T+T/T genotypes and increased serum levels of IL-17F in patients with AS and also in controls. We can conclude that patients with the A/G and G/G genotypes for −1082 A>G (rs1800896) in the IL10 gene are three times more likely to develop AS, that the serum level of IL-10 was higher in AS patients and that the IL17F rs763780 polymorphism can affect the levels of IL-17F in the serum of patients and controls in the same way.

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“…[12,21] The expression of MMP genes were found to be associated with several proinflammatory cytokines, such as tumor necrosis factor-alfa (TNF-α) and IL-17. [22,23] Recent studies have indicated that single-nucleotide polymorphisms (SNPs) in IL and ERAP are associated with an increased risk of AS, [24,25] while few studies concentrated on the correlation between SNPs in MMP and AS. In addition, there is no report on the relationship between MMP-8 and AS.…”

Section: Introductionmentioning

confidence: 99%

MMP-8 single-nucleotide polymorphisms are related to ankylosing spondylitis in Chinese Han population

Meng

Bai

Zhao³

et al. 2018

Medicine

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Ankylosing spondylitis (AS) is an extreme form of inflammatory arthritis which always leads to bony fusion of vertebral and chronic pain of back. A lot of genes including interleukin, matrix metalloproteinases (MMPs), and endoplasmic reticulum aminopeptidase were found associated with AS. MMP family members were involved in the autoimmune disease and orthopedic diseases such as rheumatoid arthritis and osteoarthritis, while few studies concentrated on the correlation between single-nucleotide polymorphisms (SNPs) in MMP and AS. In addition, there is no report on the relationship between MMP-8 and AS. To investigate the association between SNPs in MMP-8 and AS, we recruited 268 patients with AS and 654 healthy people to conduct a case-control study. Five SNPs including rs3740938, rs2012390, rs1940475, rs11225394, and rs11225395 of MMP-8 gene were genotyped. It was found rs3740938 of MMP-8 was associated with an increased risk of AS under the dominant model and additive model after adjustment for gender and age by performing logistic regression analysis (odds ratio [OR] = 1.49, 95% confidence interval [CI] = 1.02-2.18, P = .038; OR = 1.37, 95% CI = 1.01-1.87, P = .042, respectively). Moreover, haplotype "GGTCA" was associated with an increased risk of AS without adjustment for age and gender (OR = 1.75, 95% CI = 1.05-2.92, P = .032), while no positive result was found after adjustment for age and gender. Based on our results, our study indicates significant association between SNPs of MMP-8 and AS risk in a Chinese Han population and these results provide the first evidence that MMP-8 is correlated with AS.

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IL-23R and IL-17A polymorphisms correlate with susceptibility of ankylosing spondylitis in a Southwest Chinese population

Cited by 16 publications

References 36 publications

The role of IL-17A in axial spondyloarthritis and psoriatic arthritis: recent advances and controversies

The role of IL-17A in axial spondyloarthritis and psoriatic arthritis: recent advances and controversies

Influence of IL10 (rs1800896) Polymorphism and TNF-α, IL-10, IL-17A, and IL-17F Serum Levels in Ankylosing Spondylitis

MMP-8 single-nucleotide polymorphisms are related to ankylosing spondylitis in Chinese Han population

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