The Relationship Between Breast Cancer and Risk Factors: A Single-Center Study

Özsoy, Arzu; Barça, Nurdan; Dolek, Betul Akdal; Aktaş, Hafize; Elverici, Eda; Araz, Levent; Ozkaraoğlu, Ozlen

doi:10.5152/tjbh.2017.3180

Cited by 33 publications

(37 citation statements)

References 17 publications

(7 reference statements)

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“…Certain major risk factors for breast cancer are beyond individual's control. 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 For example, simply being a woman is the main risk factor for breast cancer as this disease is about 100 times more likely to occur in women than in men. Aging inevitably increases one's risk of breast cancer as evinced by the fact that most breast cancers are diagnosed in women age 55 and older.…”

Section: Disease Landscape and Risk Factors Of Breast Cancermentioning

confidence: 99%

“…Family history of breast cancer: While less than 15% of women with breast cancer have a family member with this disease, women who do have close blood relatives with breast cancer have a higher risk. 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 25 For instance, having a first-degree relative (mother, sister, or daughter) with breast cancer almost doubles a woman's risk while having two first-degree relatives with the disease increases the woman's risk about 3-fold. Interestingly, women with a father or brother who have breast cancer also have a higher risk of breast cancer.…”

Section: Disease Landscape and Risk Factors Of Breast Cancermentioning

confidence: 99%

“…Other races such as Asian, Hispanic, and Native American women have a lower risk of developing and dying from breast cancer. 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 …”

Section: Disease Landscape and Risk Factors Of Breast Cancermentioning

confidence: 99%

“…Certain proliferative breast lesions: Some proliferative lesions without atypia seem to raise a woman's risk of breast cancer slightly. 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 Examples of such proliferative lesions are ductal hyperplasia, fibroadenoma, sclerosing adenosis, papillomatosis or radial scar. However, certain proliferative lesions with atypia in the ducts or lobules of the breast tissue will increase breast cancer risk 4–5-fold; and these include atypical ductal hyperplasia (ADH) and atypical lobular hyperplasia (ALH).…”

Section: Disease Landscape and Risk Factors Of Breast Cancermentioning

confidence: 99%

“…Lobular carcinoma in situ (LCIS) or lobular neoplasia: LCIS cells are cancer-like and grow in the lobules of the milk-producing glands of the breast, but are limited within the walls of the lobules. 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 LCIS is traditionally grouped with ductal carcinoma in situ (DCIS) as a non-invasive breast cancer, while recent updates in the field consider LCIS to be benign. However, LCIS differs from DCIS in that it usually does progress to become invasive cancer if it is not treated.…”

Section: Disease Landscape and Risk Factors Of Breast Cancermentioning

confidence: 99%

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Breast cancer development and progression: Risk factors, cancer stem cells, signaling pathways, genomics, and molecular pathogenesis

et al. 2018

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As the most commonly occurring cancer in women worldwide, breast cancer poses a formidable public health challenge on a global scale. Breast cancer consists of a group of biologically and molecularly heterogeneous diseases originated from the breast. While the risk factors associated with this cancer varies with respect to other cancers, genetic predisposition, most notably mutations in BRCA1 or BRCA2 gene, is an important causative factor for this malignancy. Breast cancers can begin in different areas of the breast, such as the ducts, the lobules, or the tissue in between. Within the large group of diverse breast carcinomas, there are various denoted types of breast cancer based on their invasiveness relative to the primary tumor sites. It is important to distinguish between the various subtypes because they have different prognoses and treatment implications. As there are remarkable parallels between normal development and breast cancer progression at the molecular level, it has been postulated that breast cancer may be derived from mammary cancer stem cells. Normal breast development and mammary stem cells are regulated by several signaling pathways, such as estrogen receptors (ERs), HER2, and Wnt/β-catenin signaling pathways, which control stem cell proliferation, cell death, cell differentiation, and cell motility. Furthermore, emerging evidence indicates that epigenetic regulations and noncoding RNAs may play important roles in breast cancer development and may contribute to the heterogeneity and metastatic aspects of breast cancer, especially for triple-negative breast cancer. This review provides a comprehensive survey of the molecular, cellular and genetic aspects of breast cancer.

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Section: Disease Landscape and Risk Factors Of Breast Cancermentioning

confidence: 99%

Section: Disease Landscape and Risk Factors Of Breast Cancermentioning

confidence: 99%

“…Other races such as Asian, Hispanic, and Native American women have a lower risk of developing and dying from breast cancer. 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 …”

Section: Disease Landscape and Risk Factors Of Breast Cancermentioning

confidence: 99%

Section: Disease Landscape and Risk Factors Of Breast Cancermentioning

confidence: 99%

Section: Disease Landscape and Risk Factors Of Breast Cancermentioning

confidence: 99%

See 3 more Smart Citations

Breast cancer development and progression: Risk factors, cancer stem cells, signaling pathways, genomics, and molecular pathogenesis

et al. 2018

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Higher dietary acid load is not associated with risk of breast cancer in Iranian women

et al. 2019

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Background: Dietary acid load (DAL) may play a key role in certain cancers, including breast cancer (BC); however, evidence showing a causal relationship is lacking.Aim: We examined the relationship between DAL, assessed with both the potential renal acid load (PRAL) and the net endogenous acid production (NEAP) scores, and BC risk. Methods:We identified 150 women who had a diagnosis of BC recently and 150 age-matched apparently healthy controls. Data from dietary intake and anthropometric measures were collected from participants and eventually, PRAL and NEAP scores were obtained from nutrient intakes. Multivariate odds ratios (OR) with 95% confidence intervals (CI) were used to evaluate the relationship of BC risk with PRAL and NEAP scores. Results:The odds ratios (OR) of BC according to tertiles of PRAL and NEAP scores by multivariate logistic regression models revealed that both PRAL (P-trend = 0.8) and NEAP (P-trend = 0.1) scores were not significantly associated with BC risk. After controlling confounders, multiple logistic regressions still remained non-significant which indicated no significant associations between PRAL (P-trend = 0.9), NEAP (Ptrend = 0.4) scores and risk of BC. Conclusion:The results of our study suggested that there is no significant relationship between DAL and BC incidence among Iranian women. KEYWORDS acid-base balance, breast cancer, dietary acid load, net endogenous acid production, potential renal acid load

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Cold atmospheric plasma modification of curcumin loaded in tri‐phosphate chitosan nanoparticles enhanced breast cancer cells apoptosis

Sadoughi

Irani

Bagheri‐Khoulenjani

et al. 2020

Polymers for Advanced Techs

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The anti-cancer mechanisms of curcumin have been reported to include suppressions of angiogenesis and tumor proliferation. The main goal of this research is to increase the solubility of curcumin by cold atmospheric plasma (CAP) and assess the effects of modified curcumin by charging with tri-polyphosphate chitosan nanoparticles for MCF-7, MDA-MB-231 breast cancer cells, and human fibroblast cells. Curcumin modification was done by CAP and its solubility was evaluated by spectrophotometry. After loading modified curcumin into nano-chitosan-TPP, nanocurcumin was characterized by scanning electron microscopy. Cellular viability and apoptosis of treated cells were assessed by MTT and Annexin V. The changes of messenger RNA expression of TP5353 and VEGF genes were analyzed by real-time PCR. CAP was able to transform the curcumin to possess hydrophilic characteristics after 90 seconds. The mean diameter of Curcumin loaded chitosannanoparticles (NPs) were determined as 48 nm. MTT results showed that the IC 50 of nano Cur-chitosan-TPP was effectively decreased compared to free curcumin in MCF-7 (15 μg/mL at 72 hours vs 20 μg/mL at 48 hours). Additionally, nano Cur-chitosan-TPP had no significant effect on normal cells (Human dermal fibroblas: HDF), whereas it also decreased the viability of triple negative breast cancer cell line (MDA-MB-231). Realtime PCR results showed that expression level of TP53 gene was upregulated (P = .000), whereas VEGF gene downregulated (P = .000) in treated MCF-7 cells. Curcumin loaded chitosan nanoparticles have led to an induction of apoptosis (79.93%) and cell cycle arrest (at S and G2M). Modified-curcumin-tri-polyphosphate chitosan nanoparticles using CAP can be considered as a proper candidate for breast cancer treatment.

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The Relationship Between Breast Cancer and Risk Factors: A Single-Center Study

Cited by 33 publications

References 17 publications

Breast cancer development and progression: Risk factors, cancer stem cells, signaling pathways, genomics, and molecular pathogenesis

Breast cancer development and progression: Risk factors, cancer stem cells, signaling pathways, genomics, and molecular pathogenesis

Higher dietary acid load is not associated with risk of breast cancer in Iranian women

Cold atmospheric plasma modification of curcumin loaded in tri‐phosphate chitosan nanoparticles enhanced breast cancer cells apoptosis

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