The Relationship Between Birth Weight and Childhood Asthma

Sin, Don D.; Spier, Sheldon; Svenson, Larry; Schopflocher, Don; Senthilselvan, Ambikaipakan; Cowie, Robert L.; Man, S. F. Paul

doi:10.1001/archpedi.158.1.60

Cited by 71 publications

(73 citation statements)

References 25 publications

(24 reference statements)

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“…Respiratory symptoms were highly correlated with childhood obesity through the effects of high levels of leptin and proinflammatory cytokines [9,[11][12][13]. Our findings are in line with the hypothesis that children with a history of obesity in infancy and childhood have higher risks of respiratory health outcomes synergistically.…”

Section: Discussionsupporting

confidence: 82%

“…In accordance with previous epidemiological studies [8,[28][29][30], our data show that a higher childhood BMI is associated with an increased risk for allergic respiratory symptoms and showed significant trends on serious phenotypes. Possible explanations for the increased risk in obese children might be systematic immunological changes through higher levels of proinflammatory cytokines, such as leptin, interleukin-18 and tumour necrosis factor-a [9][10][11][12][13][14]. This immunological change, an important element of asthma pathophysiology, may affect airway function in the short and long term [9,[11][12][13].…”

Section: Discussionmentioning

confidence: 99%

“…Possible explanations for the increased risk in obese children might be systematic immunological changes through higher levels of proinflammatory cytokines, such as leptin, interleukin-18 and tumour necrosis factor-a [9][10][11][12][13][14]. This immunological change, an important element of asthma pathophysiology, may affect airway function in the short and long term [9,[11][12][13]. Conversely, obesity has also been noted to adversely affect lung function by decreasing expiratory flow rates and reducing airway calibre, leading to a worsening of respiratory symptoms [9,31].…”

Section: Discussionmentioning

confidence: 99%

“…The prevalence and incidence of allergic respiratory symptoms in children are also steadily increasing worldwide [4][5][6], which has led to the hypothesis that the two epidemics are somehow related [2,3,7,8]. Systematic immunological changes of pro-inflammatory cytokines, which could influence respiratory health, have been suggested as a possible mechanistic link between the two [9][10][11][12][13][14].…”

mentioning

confidence: 99%

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Joint effects of birth outcomes and childhood body mass index on respiratory symptoms

Wang

Chen²,

Hsieh³

et al. 2012

Eur Respir J

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Thinness in infancy and higher childhood body mass index (BMI) are risk factors for poor respiratory health. However, few studies have examined the joint effects of birth outcomes and childhood BMI on the occurrence of respiratory symptoms.A total of 78,011 Taiwanese middle-school children were investigated between 1995 and 1996 in a nationwide International Study of Asthma and Allergies in Childhood (ISAAC) survey, with standardised height/weight measurement. Their survey data was compared successfully with the birth registration dataset.Childhood BMI was positively associated with all respiratory symptoms, with greater effects and significant risks associated with serious phenotypes in the video questionnaire. Children with a history of low birth weight (LBW), those who were born prematurely (pre-term), or those who were small for gestational age (SGA) were also more likely to have allergic respiratory symptoms. As birthweight and gestational age were not positively associated with childhood BMI, we proposed that LBW, pre-term birth and childhood BMI were independent factors for respiratory symptoms.LBW, pre-term birth and childhood BMI are all independent risk factors for respiratory symptoms in children. Children with a history of LBW, pre-term birth or SGA and a higher current BMI might have larger respiratory burden.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Joint effects of birth outcomes and childhood body mass index on respiratory symptoms

Wang

Chen²,

Hsieh³

et al. 2012

Eur Respir J

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show abstract

“…Evidence suggests that obesity complicates the diagnosis, treatment, and course of asthma (20), whereas significant weight loss results in improved pulmonary status (21,22). Finally, excess body weight may precede and precipitate the onset of asthma, with preliminary evidence supporting this finding even in high-birth-weight infants (23,24). A lack of consensus exists in the literature, however, as other studies have not documented such associations (25)(26)(27).…”

Section: Introductionmentioning

confidence: 99%

Frequency and Correlates of Overweight Status in Adolescent Asthma

Abramson¹,

Wamboldt²,

Mansell³

et al. 2008

Journal of Asthma

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On the adjustment for covariates in genetic association analysis: a novel, simple principle to infer direct causal effects

Vansteelandt

Goetgeluk

Lutz

et al. 2009

Genetic Epidemiology

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In genetic association studies, different complex phenotypes are often associated with the same marker. Such associations can be indicative of pleiotropy (i.e. common genetic causes), of indirect genetic effects via one of these phenotypes, or can be solely attributable to non-genetic/environmental links between the traits. To identify the phenotypes with the inducing genetic association, statistical methodology is needed that is able to distinguish between the different causes of the genetic associations. Here, we propose a simple, general adjustment principle that can be incorporated into many standard genetic association tests which are then able to infer whether an SNP has a direct biological influence on a given trait other than through the SNP’s influence on another correlated phenotype. Using simulation studies, we show that, in the presence of a non-marker related link between phenotypes, standard association tests without the proposed adjustment can be biased. In contrast to that, the proposed methodology remains unbiased. Its achieved power levels are identical to those of standard adjustment methods, making the adjustment principle universally applicable in genetic association studies. The principle is illustrated by an application to three genome-wide association analyses.

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The Relationship Between Birth Weight and Childhood Asthma

Abstract: A high, but not low, birth weight is a risk factor for increased emergency visits during childhood. The risk increases linearly beyond a birth weight of 4.5 kg.

Cited by 71 publications

References 25 publications

Joint effects of birth outcomes and childhood body mass index on respiratory symptoms

Joint effects of birth outcomes and childhood body mass index on respiratory symptoms

Frequency and Correlates of Overweight Status in Adolescent Asthma

On the adjustment for covariates in genetic association analysis: a novel, simple principle to infer direct causal effects

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