The Relationship between Association between Blood Pressure and Risk of Cancer Development

Abstract

Background of the Study: We investigated the link between hypertension and cancer since it has been suggested that hypertension may raise the long-term risk of cancer. Previous large observational cohort studies found that greater blood pressure (BP) was related to a higher risk of cancer. Mendelian randomization (MR) was utilized to produce less confounded blood pressure estimates (BP) on overall and site-specific malignancies. The study aims to draw conclusions on the relationship between high blood pressure and cancer. Methods: Studies on high blood pressure and various malignancies are inconclusive, except for renal cell carcinoma. However, given that most meta-analyses only contained a limited number of trials, some relative risks had small to moderate magnitudes, and several may have been impacted by residual confounding, careful interpretation is necessary. The study was conducted using the meta-analysis technique. Cochran's Q test and I2 test were used to assess statistical heterogeneity between studies in the current investigation for research involving two or more cause and outcome combinations. Results: Positive correlations were also reported between high blood pressure and esophageal adenocarcinoma, squamous cell carcinoma, liver, and squamous cell carcinoma. However, most studies lacked multivariable adjustments. Physical and numerical risk of cardiovascular disease is linked to bowel cancer but no other cancers. According to a meta-analysis, hypertensive persons could also be at increased danger of gastrointestinal and breast cancer. Most meta-analyses comprised several trials with moderate or mild hazard ratios.ConclusionDifferent types of cancers have been noted to be directly caused by hypertension. In addition, some treatments have also been associated with the side effects of cancer treatments to cause hypertension. Women facing hypertension have an increased risk of getting breast cancer. Although some cancers showed a real relationship with hypertension, others had no connection at all.

Cancer Patients' Quality of Life

“…Others refer to patients being treated or having been treated some months before measurement [30,[33][34][35]. With regard to cancer survivors, differences have been found with respect to some aspects of life: marital status, the number of infants and insurance facilities for patients with Hodgkin's Disease (28); satisfaction with costs of living, taxes, national government and leisure activities for patients having been radiated [29]; psychosocial complaints, malaise, satisfaction with sleep, physical condition and life as a whole for patients having undergone chemotherapy [20), health concerns and self control [31 J and physical disability C32] in mixed patient groups. However, no differences were found with respect to most QL indicators: satisfaction with family, friends, work, income, values, activities, community, local government, health and the overall quality of life [29 J, psychological functioning [32], anxiety, depression, positive wellbeing, mental and general well-being [31 J, daily activities [20] and work rehabilitation [28).…”

“…However, no differences were found with respect to most QL indicators: satisfaction with family, friends, work, income, values, activities, community, local government, health and the overall quality of life [29 J, psychological functioning [32], anxiety, depression, positive wellbeing, mental and general well-being [31 J, daily activities [20] and work rehabilitation [28). Interestingly enough, survived cancer patients even seemed more satisfied with care from the partner and others than healthy controls are [20]. As in the studies referring to patients being treated more recently, the results look similar.…”

Obesity and endometrial cancer: the role insulin resistance and adipokines

“…The development of cancer prevention and treatment techniques may benefit from understanding the pathophysiological mechanisms underlying the link between obesity and malignancy. A group of researchers found that obesity can lead to hypertension which also increases cancer risk (Tzenios, Tazanios, & Chahine, 2022b).…”

Impact of Genetic Cancer to Family Members

“…In 1971, when Richard Nixon announced the war on cancer, the other scientists as well as the public were very optimistic towards this approach. By identifying a single gene or a cause or a handful of genes or a handful of causes for cancer [3,4], we would be able to identify some sort of a silver bullet that would allow us to eliminate this disease. It is really appreciating that cancer is the amalgam of hundreds of other diseases which is a much more intricate challenge to be faced.…”