The Relationship Between Alzheimer’s Disease and Skin Diseases: A Review

Zhang, Hanlin; Zhang, Dingyue; Tang, Keyun; Sun, Qiuning

doi:10.2147/ccid.s322530

Cited by 8 publications

(7 citation statements)

References 108 publications

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“…Patients with Alzheimer's disease have significantly higher rates of autoantibody detection than controls 26 . Alzheimer's disease is epidemiologically associated with autoimmune diseases such as rheumatoid arthritis, 27 bullous pemphigoid, 28 pyogenic hidradenitis 28 and systemic lupus erythematosus 29 . The genetic loci associated with Alzheimer's disease include genes related to the immune system 30 .…”

Section: Discussionmentioning

confidence: 99%

Risk factors, treatment and survival rates of late‐onset acquired haemophilia A: A cohort study from the Shizuoka Kokuho Database

et al. 2023

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Introduction:Acquired haemophilia A (AHA) is a rare disease. The risk factors have yet to be studied. Aim:We aimed to identify risk factors for late-onset AHA in Japan. Methods:A population-based cohort study was conducted using data from the Shizuoka Kokuho Database. The study population was defined as individuals aged ≥60 years. Cause-specific Cox regression analysis was performed to calculate hazard ratios.Results: Of 1,160,934 registrants, there were 34 patients with newly diagnosed AHA.The mean follow-up period was 5.6 years, and the incidence of AHA was 5.21 per million person-years. Myocardial infarction, diabetes mellitus, solid tumors, antimicrobial agents, phenytoin and anti-dementia drugs, which showed significant differences in the univariate analysis, were excluded from the multivariable analysis because of the small number of cases. Multivariable regression analysis showed that the presence of Alzheimer's disease (hazard ratio [HR]:4.28, 95% confidence interval [CI]:1.67-10.97) and rheumatic disease (HR:4.65, 95% CI:1.79-12.12) increased the risk of AHA development. Conclusion:We found that comorbid Alzheimer's disease is a risk factor of AHA incidence in the general population. Our findings provide insight into the etiology of AHA, and the proof of the coexistence of Alzheimer's disease may support the recent notion that Alzheimer disease is an autoimmune disease.

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Section: Discussionmentioning

confidence: 99%

Risk factors, treatment and survival rates of late‐onset acquired haemophilia A: A cohort study from the Shizuoka Kokuho Database

et al. 2023

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“…They concluded that most studies support such a hypothesis, but of course, more studies are required for definite conclusions (Zhao et al, 2021 ). A review by Zhang et al introduced a hypothesis of a bidirectional link between psoriasis and AD: on one hand, psoriasis predisposes to AD, but on the other hand, AD patients may be at increased risk of psoriasis (Zhang et al, 2021 ). The authors justified the relationship between these two diseases by the common background: inflammatory, immunological, and genetic (Zhang et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

“…A review by Zhang et al introduced a hypothesis of a bidirectional link between psoriasis and AD: on one hand, psoriasis predisposes to AD, but on the other hand, AD patients may be at increased risk of psoriasis (Zhang et al, 2021 ). The authors justified the relationship between these two diseases by the common background: inflammatory, immunological, and genetic (Zhang et al, 2021 ). In the last two reviews, which concerned PD, there were discrepancies.…”

Section: Discussionmentioning

confidence: 99%

Psoriasis and neurodegenerative diseases—a review

Nowowiejska

Baran

Flisiak

2022

Front. Mol. Neurosci.

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Psoriasis is a chronic skin disease with underlying genetic, inflammatory and immunological background, which is a great medical problem, currently regarded as a systemic condition. Neurodegenerative diseases (NDs) are characterized by a progressive loss of nervous tissue, which affects elderly people more frequently; therefore, it is suspected that, due to society's aging, morbidity is going to increase. We performed a thorough review in order to investigate for the first time whether psoriasis may predispose to different particular neurodegenerative diseases—Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS). PubMed search resulted in the retrieval of 833 records, of which 77 eligible were included in the review. Our thorough analysis revealed there are some potential links between psoriasis and NDs (inflammation, oxidative stress, genetics, cardiometabolic disorders), but there is no strong evidence that psoriasis may predispose to NDs. Based on the evidence, it seems that the risk of PD in psoriatics is not increased, and the evidence for increased risk of AD slightly prevails the data that state the opposite. ALS risk does not seem to be increased in psoriatics. The paucity of original studies does not allow for the formulation of definitive conclusions but encourages to perform further investigations.

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“…Taken together, the relatively elderly patient population and ever increasing prevalence have led to higher socioeconomic burden of BCC [8].It was estimated by Chen et al that the average cost for NMSC care in US is $650 million each year [9]. Apart from age, mental disorders are thought to have an effect on non-melanoma skin cancer, especially BCC [10,11].…”

Section: Introductionmentioning

confidence: 99%

A bidirectional Mendelian randomization study negates causal effects of Parkinson, Alzheimer on Basal Cell Carcinoma

Cai

Wang

et al. 2023

Preprint

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Basal cell carcinoma is the most common malignant disease of the skin. The relationship between basal cell carcinoma and neurodegenerative diseases including Parkinson’s disease and Alzheimer’s disease has been inconsistent. To determine the causal relationship, a bidirectional two sample mendelian randomization method was used to investigate causal effects. Single-nucleotide polymorphisms (SNPs) at genome-wide significance (P < 5 × 10 − 8) were identified from genome-wide association studies and a European basal cell carcinoma genome-wide association studies (GWAS) including 17,416 cases and 375,455 controls was selected. Inverse-variance weighted (IVW) method was used as the main analyses, with sensitivity analyses using weighted median and MR-PRESSO. As a result, no significance was found in the association between PKD and BCC (IVW, OR = 1.02, 95%CI[0.98–1.06], P = 0.38), neither was in AD and BCC(IVW, OR = 1.01, 95%CI[0.97–1.05], P = 0.77). Reversal estimation found no causal association between BCC and PKD(IVW-MRE, OR = 0.98, 95%CI[0.92–1.04], P = 0.45) or AD(IVW, OR = 0.98, 95%CI[0.95-1.00], P = 0.10). The results remain consistent after outlier correction and sensitivity analyses. In conclusion, PKD and AD do not necessarily reduce the risk of BCC, neither does BCC necessarily reduce the risk of PKD and AD.

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The Relationship Between Alzheimer’s Disease and Skin Diseases: A Review

Cited by 8 publications

References 108 publications

Risk factors, treatment and survival rates of late‐onset acquired haemophilia A: A cohort study from the Shizuoka Kokuho Database

Risk factors, treatment and survival rates of late‐onset acquired haemophilia A: A cohort study from the Shizuoka Kokuho Database

Psoriasis and neurodegenerative diseases—a review

A bidirectional Mendelian randomization study negates causal effects of Parkinson, Alzheimer on Basal Cell Carcinoma

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