The relationship between adipocyte fatty acid binding protein-4, retinol binding protein-4 levels and early diabetic nephropathy in patients with type 2 diabetes

Törüner, Füsun Baloş; Altınova, Alev Eroğlu; Aktürk, Müjde; Kaya, Meral; Arslan, Emre; Bukan, Neslihan; Kan, Erdal; Yetkin, İlhan; Arslan, Metin

doi:10.1016/j.diabres.2010.11.011

Cited by 28 publications

(34 citation statements)

References 30 publications

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“…Since serum creatinine is a component of the GFR estimation. Studies also noted serum A-FABP4 levels correlated positively with serum creatinine and negatively with GFR in type 2 DM patients [30, 31]. Serum A-FABP level was independently associated with macrovascular complications in type 2 DM patients [31].…”

Section: Discussionmentioning

confidence: 99%

High Serum Adipocyte Fatty Acid Binding Protein Is Associated with Metabolic Syndrome in Patients with Type 2 Diabetes

Hou

et al. 2016

Journal of Diabetes Research

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Adipocyte fatty acid binding protein (A-FABP) is a key mediator of obesity-related metabolic syndrome (MetS). The aim of this study was to evaluate the relationship between A-FABP concentration and MetS in type 2 diabetes mellitus (DM) patients. Fasting blood samples were obtained from 165 type 2 DM volunteers. MetS and its components were defined using diagnostic criteria from the International Diabetes Federation. Among 165 DM patients, 113 patients (68.5%) had MetS. Diabetic persons who had MetS had significantly higher A-FABP levels (P < 0.001) than those without MetS. Female DM persons had higher A-FABP level than man (P < 0.001). No statistically significant differences in A-FABP levels were found in use of statin, fibrate, or antidiabetic drugs. Multivariate forward stepwise linear regression analysis revealed that body fat mass (P < 0.001), logarithmically transformed creatinine (log-creatinine; P < 0.001), female DM patients (P < 0.001), and logarithmically transformed high sensitive C-reactive protein (log-hs-CRP; P = 0.013) were positively correlated, while albumin (P = 0.004) and glomerular filtration rate (GFR; P = 0.043) were negatively correlated with serum A-FABP levels in type 2 DM patients. In this study, higher serum A-FABP level was positively associated with MetS in type 2 DM patients.

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Section: Discussionmentioning

confidence: 99%

High Serum Adipocyte Fatty Acid Binding Protein Is Associated with Metabolic Syndrome in Patients with Type 2 Diabetes

Hou

et al. 2016

Journal of Diabetes Research

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“…Increased RBP-4 levels lead to reduced glucose uptake by muscle cells through inhibiting PI3K signaling pathway and serine phosphorylation of IRS1 (Wolf, 2007), followed by decreased insulin sensitivity. Some studies demonstrated an inverse correlation between glucose transporter 4 (GLUT4) protein expression and plasma RBP-4 levels (Graham et al, 2006; Esteve et al, 2009; Toruner et al, 2010). Decreased GLUT4 expression is accompanied by increased RBP-4 secretion in the adipose tissue of obese subjects and reduced GLUT4 expression can be caused by increased RBP-4 secretion (Yang et al, 2005).…”

Section: The Changes Of Novel Adipokines After Bariatric Surgery and mentioning

confidence: 99%

Effects of Bariatric Surgery on Adipokine-Induced Inflammation and Insulin Resistance

Göktaş¹,

Moustaid‐Moussa²,

Shen³

et al. 2013

Front. Endocrinol.

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Over a third of the US population is obese and at high risk for developing type 2 diabetes, insulin resistance, and other metabolic disorders. Obesity is considered a chronic low-grade inflammatory condition that is primarily attributed to expansion and inflammation of adipose tissues. Indeed, adipocytes produce and secrete numerous proinflammatory and anti-inflammatory cytokines known as adipokines. When the balance of these adipokines is shifted toward higher production of proinflammatory factors, local inflammation within adipose tissues and subsequently systemic inflammation occur. These adipokines including leptin, visfatin, resistin, apelin, vaspin, and retinol binding protein-4 can regulate inflammatory responses and contribute to the pathogenesis of diabetes. These effects are mediated by key inflammatory signaling molecules including activated serine kinases such as c-Jun N-terminal kinase and serine kinases inhibitor κB kinase and insulin signaling molecules including insulin receptor substrates, protein kinase B (PKB, also known as Akt), and nuclear factor kappa B. Bariatric surgery can decrease body weight and improve insulin resistance in morbidly obese subjects. However, despite reports suggesting reduced inflammation and weight-independent effects of bariatric surgery on glucose metabolism, mechanisms behind such improvements are not yet well understood. This review article focuses on some of these novel adipokines and discusses their changes after bariatric surgery and their relationship to insulin resistance, fat mass, inflammation, and glucose homeostasis.

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“…Recent human studies have confirmed its association with diabetes mellitus, non-alcoholic fatty liver disease, and cardiovascular disease. Circulating A-FABP level is also an independent predictor of metabolic syndrome development and coronary heart disease outcomes [10-14]. …”

Section: Introductionmentioning

confidence: 99%

Association between serum adipocyte fatty-acid binding protein concentrations, left ventricular function and myocardial perfusion abnormalities in patients with coronary artery disease

Huang

et al. 2013

Cardiovasc Diabetol

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BackgroundAdipokines, including adipocyte fatty acid-binding protein (A-FABP), have been demonstrated to be involved in the pathogenesis of atherosclerosis. In the present study, we investigated the association of circulating A-FABP level with severity of myocardial perfusion abnormalities analyzed by Tl-201 dipyridamole single-photon emission computed tomography.MethodsA total of 170 patients with coronary artery disease (CAD) from cardiovascular clinics were enrolled in the study. Serum A-FABP levels, echocardiography, and stress myocardial perfusion imaging results were analyzed.ResultsCompared with the patients with mild CAD (summed stress score [SSS] ≤ 8), those with moderate to severe CAD (SSS > 8) had significantly higher A-FABP concentrations. However, the difference was attenuated in the subgroup of patients with heart failure. In the correlation analyses, A-FABP level was correlated with age, body mass index, waist circumference, levels of creatinine, fasting glucose, high-sensitivity C-reactive protein, N-terminal pro-brain natriuretic peptide, adiponectin, and several echocardiographic parameters, including left ventricular ejection fraction. Multivariate logistic regression analysis demonstrated that the A-FABP level was not only associated with higher SSS (odds ratio, 1.30; 95% confidence interval [CI], 1.01–1.69; P = 0.048), but also an independent risk factor for heart failure (odds ratio 2.71, 95% CI, 1.23–5.94; P = 0.013).ConclusionsSerum A-FABP levels not only were associated with myocardial perfusion abnormalities and left ventricular function, but also predicted the presence of heart failure in our patients with CAD.

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The relationship between adipocyte fatty acid binding protein-4, retinol binding protein-4 levels and early diabetic nephropathy in patients with type 2 diabetes

Cited by 28 publications

References 30 publications

High Serum Adipocyte Fatty Acid Binding Protein Is Associated with Metabolic Syndrome in Patients with Type 2 Diabetes

High Serum Adipocyte Fatty Acid Binding Protein Is Associated with Metabolic Syndrome in Patients with Type 2 Diabetes

Effects of Bariatric Surgery on Adipokine-Induced Inflammation and Insulin Resistance

Association between serum adipocyte fatty-acid binding protein concentrations, left ventricular function and myocardial perfusion abnormalities in patients with coronary artery disease

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