The relationship among microsomal enzyme induction, liver weight, and histological change in cynomolgus monkey toxicology studies

Amacher, David E.; Schomaker, Shelli; Boldt, Sherri; Mirsky, Michael

doi:10.1016/j.fct.2005.08.027

Cited by 39 publications

(25 citation statements)

References 25 publications

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“…Histopathological examination of tissues is not only acknowledged as the most sensitive end point for detecting organ toxicity during exposure to toxicants (Lanning et al 2002), but is also capable of providing specific information on the acute and chronic effects of toxicants on targeted organs that may not be detected by functional biomarkers (Amacher et al 2006;Travlos et al 1996). Therefore, histological lesions on tissues serve as warning symptoms for the organism's health.…”

Section: Discussionmentioning

confidence: 98%

Cytogenotoxicity and histopathological assessment of Lekki Lagoon and Ogun River inSynodontis clarias(Linnaeus, 1758)

Alimba

Saliu

Ubani-Rex

2015

Toxicological & Environmental Chemistry

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Section: Discussionmentioning

confidence: 98%

Cytogenotoxicity and histopathological assessment of Lekki Lagoon and Ogun River inSynodontis clarias(Linnaeus, 1758)

Alimba

Saliu

Ubani-Rex

2015

Toxicological & Environmental Chemistry

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“…This increase in the relative weight of the liver can have a toxic origin or not. It could be due to an inflammation or an increase of enzymes or peroxysomes synthesis (Amacher et al, 2006;Juberg et al, 2006;Sellers et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

In vivo and in vitro toxicological evaluation of the hydroalcoholic leaf extract of Ageratum conyzoides L. (Asteraceae)

Diallo

Eklu-Gadégbéku

Amégbor

et al. 2014

Journal of Ethnopharmacology

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“…Alterations in liver weight may suggest treatment-related changes including hepatocellular hypertrophy (e.g., enzyme induction or peroxisome proliferation) (Greaves, 2000;Amacher et al, 2006;Juberg et al, 2006). Liver weights may be elevated in studies of less than 7 days duration for potent hepatic enzyme-inducing compounds.…”

Section: Organ Weights Recommended For Collection In General Toxicolomentioning

confidence: 99%

Society of Toxicologic Pathology Position Paper: Organ Weight Recommendations for Toxicology Studies

et al. 2007

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The evaluation of organ weights in toxicology studies is an integral component in the assessment of pharmaceuticals, chemicals, and medical devices. The Society of Toxicologic Pathology (STP) has created recommendations for weighing organs in GLP general toxicology studies lasting from 7 days to 1 year. The STP recommends that liver, heart, kidneys, brain, testes, and adrenal glands be weighed in all multidose general toxicology studies. Thyroid gland and pituitary gland weights are recommended for all species except mice. Spleen and thymus should be weighed in rodent studies and may be weighed in non-rodent studies. Weighing of reproductive organs is most valuable in sexually mature animals. Variability in age, sexual maturity, and stage of cycle in non-rodents and reproductive senescence in female rodents may complicate or limit interpretation of reproductive organ weights. The STP recommends that testes of all species be weighed in multidose general toxicology studies. Epididymides and prostate should be weighed in rat studies and may be weighed on a case-by-case basis in non-rodent and mouse studies. Weighing of other organs including female reproductive organs should be considered on a case-by-case basis. Organ weights are not recommended for any carcinogenicity studies including the alternative mouse bioassays. Regardless of the study type or organs evaluated, organ weight changes must be evaluated within the context of the compound class, mechanism of action, and the entire data set for that study.

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The relationship among microsomal enzyme induction, liver weight, and histological change in cynomolgus monkey toxicology studies

Cited by 39 publications

References 25 publications

Cytogenotoxicity and histopathological assessment of Lekki Lagoon and Ogun River inSynodontis clarias(Linnaeus, 1758)

Cytogenotoxicity and histopathological assessment of Lekki Lagoon and Ogun River inSynodontis clarias(Linnaeus, 1758)

In vivo and in vitro toxicological evaluation of the hydroalcoholic leaf extract of Ageratum conyzoides L. (Asteraceae)

Society of Toxicologic Pathology Position Paper: Organ Weight Recommendations for Toxicology Studies

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