In vivo and in vitro toxicological evaluation of the hydroalcoholic leaf extract of Ageratum conyzoides L. (Asteraceae)

Diallo, Aboudoulatif; Eklu-Gadégbéku, Kwashie; Amégbor, Koffi; Agbonon, Amégnona; Aklikokou, Kodjo; Creppy, Edmond E.; Gbéassor, Messanvi

doi:10.1016/j.jep.2014.07.005

Cited by 29 publications

(23 citation statements)

References 26 publications

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“…It was also evident that there are no any significant relationship between concentrations of STRE administrated that with relative organ weight. This indicate that extract did not induce any kind of xenobiotic enzyme activity or elevation of protein synthesis in study animal [31]. Similar propensity was previously observed in aqueous extract of the leaves of Herniaria glabra in rodents [32] where extract did not induce any changes in relative organ weight.…”

Section: Discussionsupporting

confidence: 85%

Acute and sub-acute toxicity study of bacterial signaling inhibitor Solanum torvum root extract in Wister rats

Vadakkan

2019

Clin Phytosci

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Background: Solanum torvum root extract is used to treat Asthma, Diabetes, and hypertension by Garo tribal healers of India and Bangladesh. Root tea is used to treat cough and fever by Attapadi tribal people of Kerala, India. The in vivo toxicological effects of Solanum torvum root extract was assessed by acute and sub-acute toxicity studies according to the OECD (Organisation for Economic Co-operation and Development) guidelines and per the guidance of Committee for the Purpose of Control and Supervision of Experiments on Animals (CPCSEA), Ministry of Environment and Forest, government of India.Results: A single dose of Solanum torvum root extract (300 mg/kg, 600 mg/kg and 1200 mg/kg) was administrated daily for 14 days to estimate acute toxicity whereas subjects were treated for 28 days to assess the sub-acute toxicity. General functional behaviors, Physiological, histological, biochemical and hematological parameters were observed to understand the effect of extract upon study animal. All the study subjects were alive after the study period after acute and sub-acute toxicity assay. Functional and behavioral characteristics such as body position, respiration, clonic involuntary movement, tonic involuntary movement, palpebral closure, approach response, touch response, pinna reflex and tail pinch response; palpebral closure, lacrimation, salivation, piloerection, pupillary reflex, abdominal tone, limb tone, when held in hand were also found to be normal. Histological, biochemical and hematological parameters were also normal compared that with untreated group. Conclusions:The acute and sub-acute toxicological analysis of Solanum torvum root extracts up on Wister rats suggested that there are no any dose response relation between extract administrated and toxicity, therefore there are no toxic effect by STRE, however more enlightenment regarding toxicity due to prolonged exposure can only be understood from chronic toxicity analysis.

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Section: Discussionsupporting

confidence: 85%

Acute and sub-acute toxicity study of bacterial signaling inhibitor Solanum torvum root extract in Wister rats

Vadakkan

2019

Clin Phytosci

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“…The rise in organ weight could be referred to stimulation of xenobiotic enzymes promoting to raise in proteins synthesis. Regularly the inducement of these enzymes leads to a raise of relative organ weight following an exposure to xenobiotic [ 49 , 50 ]. It could be argued that these alterations might be toxicological significant particularly for heart, liver, and kidney but the raise in the relative weight of spleen might be due to the high unevenness of the weight of this organ [ 51 ].…”

Section: Discussionmentioning

confidence: 99%

Antimycobacterial Activity and Safety Profile Assessment of Alpinia galanga and Tinospora cordifolia

Alajmi

Mothana

Al‐Rehaily

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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Tuberculosis (TB) remains a common deadly infectious disease and worldwide a major health problem. The current study was therefore designed to investigate the in vitro antimycobacterial activity of different extracts of Alpinia galanga and Tinospora cordifolia. Moreover, a safety assessment for both plants was carried out. Dichloromethane and ethanolic extracts of each plant were examined against H37Rv INH-sensitive and resistant INH strains of Mycobacterium tuberculosis. The safety assessment of both plants has been performed through in vivo acute and chronic toxicity studies in animal model. Body weight, food consumption, water intake, organ's weight, and haematological and biochemical parameters of blood and serum were evaluated. The extracts of A. galanga and T. cordifolia produced significant and dose-dependent inhibitory activity with maximum effect of 18-32% at 50 μg/ml against both strains of M. tuberculosis. No effect on the body weight or food and water consumption was observed but A. galanga caused significantly an increase in the relative weight of the heart, liver, spleen, and kidney. Haematological studies of both plants revealed a slight but significant fall in the RBC and WBC level as well as haemoglobin and platelets. In addition, A. galanga extracts increased significantly liver enzymes and bilirubin and glucose.

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“…conyzoides repaired acetaminophen induced hepatotoxicity in wistar rats (Verma et al, ). Diallo et al () have also studied the acute and subchronic oral toxicity of hydroalcohol leaf extract of A . conyzoides and reported that lower dose (500 mg/kg) of hydroalcholic extract of leaf does not cause liver toxicity, and it is safe to use to lower the urea level in the blood.…”

Section: Pharmacologymentioning

confidence: 99%

“…The alcoholic extract of the whole plant has been found to be toxic in mice at concentration 3,000 mg/kg body weight whereas, preexposure with acetone and n-hexane extracts (200 mg/kg, bw, orally) of A. conyzoides repaired acetaminophen induced hepatotoxicity in wistar rats (Verma et al, 2013). Diallo et al (2014) have also studied the acute and subchronic oral toxicity of hydroalcohol leaf extract of A. conyzoides and reported that lower dose (500 mg/kg) of hydroalcholic extract of leaf does not cause liver toxicity, and it is safe to use to lower the urea level in the blood.…”

Section: Toxicitymentioning

confidence: 99%

Phytochemical constituents and ethnopharmacological properties of Ageratum conyzoides L.

Yadav

Ganie

Singh

et al. 2019

Phytotherapy Research

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Ageratum conyzoides L. (Asteraceae) is an invasive aromatic herb with immense therapeutic importance. The herb is distributed in tropical and subtropical regions. A. conyzoides has imparted numerous ethnomedicinal uses because it has been used to cure various ailments that include leprosy, skin disorders, sleeping sickness, rheumatism, headaches, dyspnea, toothache, pneumonia and many more. A number of phytoconstituents have been scrutinized such as alkaloids, flavonoids, terpenes, chromenes, and sterols from almost every part of this plant. These phytoconstituents have shown diverse pharmacological properties including antimicrobial, anti‐inflammatory, analgesic, antioxidant, anticancer, antiprotozoal, antidiabetic, spasmolytic, allelopathy, and many more. The plant A. conyzoides has provided a platform for doing pharmaceutical and toxicological research in order to isolate some promising active compounds and authenticate their safety in clinical uses. A. conyzoides provides principal information for advanced studies in the field of pharmaceutical industries and agriculture. Present review article describes the cytogenetics, ethnobotany, phytochemistry, pharmacology, and toxicological aspects of A. conyzoides.

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In vivo and in vitro toxicological evaluation of the hydroalcoholic leaf extract of Ageratum conyzoides L. (Asteraceae)

Cited by 29 publications

References 26 publications

Acute and sub-acute toxicity study of bacterial signaling inhibitor Solanum torvum root extract in Wister rats

Acute and sub-acute toxicity study of bacterial signaling inhibitor Solanum torvum root extract in Wister rats

Antimycobacterial Activity and Safety Profile Assessment of Alpinia galanga and Tinospora cordifolia

Phytochemical constituents and ethnopharmacological properties of Ageratum conyzoides L.

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