The relationship among IL-13, GSTP1, and CYP1A1 polymorphisms and environmental tobacco smoke in a population of children with asthma in Northern Mexico

Muñoz, Balam; Magaña, Jonathan J.; Romero-Toledo, Israel; Juárez-Pérez, Evelyn; López-Moya, Andrea; Leyva-García, Norberto; López-Campos, Celsa; Dávila-Borja, Víctor Manuel; Albores, Arnulfo

doi:10.1016/j.etap.2011.12.007

Cited by 19 publications

(13 citation statements)

References 29 publications

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“…Two papers reported on associations between variants coding for the antioxidant protein glutathione S-transferase P1 (GSTP1) and SHS exposure [(18), p. 125; (19), p. 226–232] and neither found an association although one [(18), p. 125] was able to describe increased risk for asthma among those exposed to SHS and low dietary vitamin E, who also were genetically predisposed to oxidant stress. Two other studies related SNPs in the gene coding for GSTP1 and exposure to dampness [(20), p. e30694] and air pollution [(21), p. e52715]; one study described complicated gene–gene and gene–environment interactions for dampness (but not several other exposures) and asthma [(20), p. e30694] while the second described a small increased risk for asthma among those genetically predisposed to oxidant stress and exposed to nitrogen dioxide (NO 2 ) [(21), p. e52715].…”

Section: Gene–environment Interactions For Asthmamentioning

confidence: 99%

Gene–Environment Interactions—What Can These Tell Us about the Relationship between Asthma and Allergy?

Turner

2017

Front. Pediatr.

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Asthma is a common condition, which is associated with atopy and allergic conditions including hay fever, eczema, and food allergies. Asthma and atopy are both complex conditions where genetic and environmental factors are implicated in causation. Interactions between genetic and environmental factors, likely via epigenetic mechanisms, are widely thought to be important in determining the risk for developing asthma and atopy. The nature of the relationship between asthma and atopy is unclear and the answer to the question “does atopy cause asthma?” remains unknown. This review explores the relationship between asthma and atopy from a gene–environment interaction perspective and tackles the question “are similar gene–environment interactions present for asthma and atopy?” The main finding is that gene–environment interactions are described for asthma and atopy in children but these interactions are seldom sought for both asthma and atopy in the same population. In the few instances where a gene–environment interaction is related to both asthma and atopy, there is no consistent evidence that similar interactions are common to asthma and atopy. Many plausible gene–environment interactions for asthma and atopy are yet to be explored. Overall, from the gene–environment interaction perspective, there is absence of evidence to better understand the complex relationship between asthma and atopy.

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Section: Gene–environment Interactions For Asthmamentioning

confidence: 99%

Gene–Environment Interactions—What Can These Tell Us about the Relationship between Asthma and Allergy?

Turner

2017

Front. Pediatr.

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“…A sthma is a common chronic multifactorial disease that affects Ͼ300 million people worldwide, leading to a serious public health problem. 1 During the last decades research all over the world has highlighted that outdoor and indoor pollution exposure has been associated with respiratory health effects in adults and children. [2][3][4][5] The respiratory health risk for a child can extensively be molded by the status of the sensitive time windows of prenatal and early childhood because of adverse effects of pollutants exposure on programming of lung growth and on the maturation of innate immune cells.…”

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confidence: 99%

Smoke exposure as a risk factor for asthma in childhood: A review of current evidence

Ferrante

Antona²,

Malizia³

et al. 2014

allergy asthma proc

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Asthma is a common chronic multifactorial disease that affects >300 million people worldwide. Outdoor and indoor pollution exposure has been associated with respiratory health effects in adults and children. Smoking still represents a huge public health problem and millions of children suffer the detrimental effects of passive smoke exposure. This study was designed to review the current evidences on exposure to passive smoke as a risk factor for asthma onset in childhood. A review of the most recent studies on this topic was undertaken to provide evidence about the magnitude of the effect of passive smoking on the risk of incidence of asthma in children. The effects of passive smoking are different depending on individual and environmental factors. Environmental tobacco smoke (ETS) is one of the most important indoor air pollutants and can interact with other air pollutants in eliciting respiratory outcomes during childhood. The increased risk of respiratory outcomes in children exposed to prenatal and early postnatal passive smoke might be caused by an adverse effect on both the immune system and the structural and functional development of the lung; this may explain the subsequent increased risk of incident asthma. The magnitude of the exposure is quite difficult to precisely quantify because it is significantly influenced by the child's daily activities. Because exposure to ETS is a likely cause for asthma onset in childhood, there is a strong need to prevent infants and children from breathing air contaminated with tobacco smoke.

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“…In this current study, a total of 34 eligible studies met the inclusion criteria [7]–[40]. Four articles reported two cohorts [12], [14], [33], [38], and each cohort was considered as a case-control study.…”

Section: Resultsmentioning

confidence: 99%

“…So far, a lot of studies investigated the association between the IL-13 gene polymorphisms and susceptibility of asthma [7]–[40]. Most of them focused on two polymorphisms: -1112C/T and +2044A/G.…”

Section: Introductionmentioning

confidence: 99%

Effects of Polymorphisms -1112C/T and +2044A/G in Interleukin-13 Gene on Asthma Risk: A Meta-Analysis

et al. 2013

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BackgroundAssociations between interleukin-13 (IL-13) polymorphisms and asthma risk remained controversial and ambiguous. Therefore, we performed a meta-analysis to assess the associations between IL-13 polymorphisms and asthma susceptibility.MethodsPubmed, EMBASE, Chinese National Knowledge Infrastructure (CNKI) and Wangfang databases were searched. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to calculate the strength of association in the random-effects model.ResultsThirty-four studies were included in this meta-analysis. The results indicated that IL13 -1112C/T polymorphism was significantly associated with asthma risk (OR = 1.20, 95% CI 1.08–1.34, P = 0.0009) in a dominant genetic model. When stratifying for race, IL13 -1112C/T polymorphism exhibited increased asthma risk in Caucasians (OR = 1.30, 95% CI 1.09–1.55, P = 0.003), while no significant association was found in Asians and African Americans. In the subgroup analysis based on atopic status, significant association was observed in atopic patients (OR = 1.25, 95% CI 1.07–1.45, P = 0.004) but not in the non-atopic patients. In addition, a significant association between IL13+2044A/G polymorphism and asthma risk was observed (OR = 1.18, 95% CI 1.08–1.28, P = 0.0002). In the subgroup analysis by ethnicity, there were significant associations between IL13+2044A/G polymorphism and asthma risk in Asians (OR = 1.19, 95% CI 1.04–1.36, P = 0.01) and Caucasians (OR = 1.22, 95% CI 1.06–1.40, P = 0.005) but not in African Americans. In the subgroup analysis stratified by atopic status, a marginal significant association was found in atopic patients (OR = 1.12, 95% CI 1.00–1.26, P = 0.05).ConclusionsThis meta-analysis suggested that the IL13 -1112C/T and +2044A/G polymorphisms were risk factors for asthma.

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The relationship among IL-13, GSTP1, and CYP1A1 polymorphisms and environmental tobacco smoke in a population of children with asthma in Northern Mexico

Cited by 19 publications

References 29 publications

Gene–Environment Interactions—What Can These Tell Us about the Relationship between Asthma and Allergy?

Gene–Environment Interactions—What Can These Tell Us about the Relationship between Asthma and Allergy?

Smoke exposure as a risk factor for asthma in childhood: A review of current evidence

Effects of Polymorphisms -1112C/T and +2044A/G in Interleukin-13 Gene on Asthma Risk: A Meta-Analysis

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