Effects of Polymorphisms -1112C/T and +2044A/G in Interleukin-13 Gene on Asthma Risk: A Meta-Analysis

Abstract

BackgroundAssociations between interleukin-13 (IL-13) polymorphisms and asthma risk remained controversial and ambiguous. Therefore, we performed a meta-analysis to assess the associations between IL-13 polymorphisms and asthma susceptibility.MethodsPubmed, EMBASE, Chinese National Knowledge Infrastructure (CNKI) and Wangfang databases were searched. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to calculate the strength of association in the random-effects model.ResultsThirty-four studies were included in this meta-analysis. The results indicated that IL13 -1112C/T polymorphism was significantly associated with asthma risk (OR = 1.20, 95% CI 1.08–1.34, P = 0.0009) in a dominant genetic model. When stratifying for race, IL13 -1112C/T polymorphism exhibited increased asthma risk in Caucasians (OR = 1.30, 95% CI 1.09–1.55, P = 0.003), while no significant association was found in Asians and African Americans. In the subgroup analysis based on atopic status, significant association was observed in atopic patients (OR = 1.25, 95% CI 1.07–1.45, P = 0.004) but not in the non-atopic patients. In addition, a significant association between IL13+2044A/G polymorphism and asthma risk was observed (OR = 1.18, 95% CI 1.08–1.28, P = 0.0002). In the subgroup analysis by ethnicity, there were significant associations between IL13+2044A/G polymorphism and asthma risk in Asians (OR = 1.19, 95% CI 1.04–1.36, P = 0.01) and Caucasians (OR = 1.22, 95% CI 1.06–1.40, P = 0.005) but not in African Americans. In the subgroup analysis stratified by atopic status, a marginal significant association was found in atopic patients (OR = 1.12, 95% CI 1.00–1.26, P = 0.05).ConclusionsThis meta-analysis suggested that the IL13 -1112C/T and +2044A/G polymorphisms were risk factors for asthma.

Self-Reported Allergic Rhinitis and/or Allergic Conjunctivitis Associate with <b><i>IL13</i></b> rs20541 Polymorphism in Finnish Adult Asthma Patients

“…A meta-analysis suggests that the IL13 rs20541 G/A polymorphism is associated with (allergic) asthma [24]. A study group examined the impact of IL13 rs20541 G→A on the functional properties of IL-13 by directly comparing the activity of wild-type IL-13 and IL-13 R130Q on primary human cells [11].…”

Involvement of lymphocytes in asthma and allergic diseases

“…Importantly, gene-environment interactions between the IL-4 promoter and mold exposure are related to the development of asthma in children [26]. A recent meta-analysis also confirmed IL-13-1112C/T polymorphism exhibited increased asthma risk in whites [odds ratio (OR) ¼ 1.30] and in atopic patients (OR ¼ 1.25) [28]. SNP rs2244012 in intron 2 of RAD50 has been identified as risk factor for severe asthma.…”

“…In a recent meta-analysis of 3000 asthmatic patients, C-589T represented as a low-penetrant risk factor for atopic asthma [27]. 19) and whites (OR¼1.22) [28]. SNP-1112C/T on IL-13 promoter increases IL-13 transcription, and the IL-13þ2044A/ G SNP located on exon 4 is associated with more active IL-13 function.…”

Angiotensin-converting enzyme I/D polymorphism is associated with pneumonia risk: A meta-analysis

“…These pairwise differences were used to indicate the most appropriate genetic model as following: if OR1 = OR3 ≠ 1 and OR2 = 1, then a recessive model was suggested; if OR1 = OR2 ≠ 1 and OR3 = 1, then a dominant model was suggested; if OR2 = 1/OR3 ≠ 1 and OR1 = 1, then a complete overdominant model was suggested; if OR1 > OR2 > 1 and OR1 > OR3 > 1 (or OR1 < OR2 < 1 and OR1 < OR3 < 1), then a codominant model was suggested. [19][20][21][22][23] Once the best genetic model was identified, this model was used to collapse the three genotypes into two groups (except in the case of a codominant model) and to pool the results again. The significance of the pooled OR was determined by the z-test, and two-tailed p < 0.05 was considered as statistically significant.…”