The Relation to Alcohol to Arteriosclerosis.

Cabot, Richard C.

doi:10.1001/jama.1904.92500120002a

Cited by 52 publications

(10 citation statements)

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“…On the other hand, it has been noted as early as 1904 that alcohol consumption is associated with positive effects on the cardiovascular ( Cabot, 1904 ) system. There is now almost unanimous agreement (but see Fillmore et al ., 2006 ) that regular low‐to‐moderate alcohol consumption leads to significant positive effects on health and longevity ( Zakhari and Gordis, 1999 ; Klatsky, 2003 ; Mukamal et al ., 2003 ).…”

Section: Pleiotropic Effects Of Alcoholmentioning

confidence: 99%

Physiology and pharmacology of alcohol: the imidazobenzodiazepine alcohol antagonist site on subtypes of GABA_A receptors as an opportunity for drug development?

Wallner

Olsen

2008

British J Pharmacology

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Alcohol (ethanol, EtOH) has pleiotropic actions and induces a number of acute and long-term effects due to direct actions on alcohol targets, and effects of alcohol metabolites and metabolism. Many detrimental health consequences are due to EtOH metabolism and metabolites, in particular acetaldehyde, whose high reactivity leads to nonspecific chemical modifications of proteins and nucleic acids. Like acetaldehyde, alcohol has been widely considered a nonspecific drug, despite rather persuasive evidence implicating inhibitory GABA A receptors (GABA A Rs) in acute alcohol actions, for example, a GABA A R ligand, the imidazobenzodiazepine Ro15-4513 antagonizes many low-to-moderate dose alcohol actions in mammals. It was therefore rather surprising that abundant types of synaptic GABA A Rs are generally not responsive to relevant low concentrations of EtOH. In contrast, d-subunit-containing GABA A Rs and extrasynaptic tonic GABA currents mediated by these receptors are sensitive to alcohol concentrations that are reached in blood and tissues during low-to-moderate alcohol consumption. We recently showed that low-dose alcohol enhancement on highly alcohol-sensitive GABA A R subtypes is antagonized by Ro15-4513 in an apparently competitive manner, providing a molecular explanation for behavioural Ro15-4513 alcohol antagonism. The identification of a Ro15-4513/EtOH binding site on unique GABA A R subtypes opens the possibility to characterize this alcohol site(s) and screen for compounds that modulate the function of EtOH/Ro15-4513-sensitive GABA A Rs. The utility of such drugs might range from novel alcohol antagonists that might be useful in the emergency room, to drugs for the treatment of alcoholism, as well as alcohol-mimetic drugs to harness acute positive effects of alcohol.

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Section: Pleiotropic Effects Of Alcoholmentioning

confidence: 99%

Physiology and pharmacology of alcohol: the imidazobenzodiazepine alcohol antagonist site on subtypes of GABA_A receptors as an opportunity for drug development?

Wallner

Olsen

2008

British J Pharmacology

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“…This phenomenon was first noted by the Irish physician Samuel Black (1819) who attributed the observation to the French habit of drinking red wine with meals, while the first scientific study was published by Cabot (1904), and the first comparison of coronary heart disease mortality between wine‐drinking countries and those where beer or spirits were consumed was made 75 years later (St. Leger et al., 1979).…”

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confidence: 95%

The Biological Responses to Resveratrol and Other Polyphenols From Alcoholic Beverages

Brown

Kroon

Das

et al. 2009

Alcoholism Clin & Exp Res

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Although excessive consumption of ethanol in alcoholic beverages causes multi-organ damage, moderate consumption, particularly of red wine, is protective against all-cause mortality. These protective effects could be due to one or many components of the complex mixture of bioactive compounds present in red wine including flavonols, monomeric and polymeric flavan-3-ols, highly coloured anthocyanins as well as phenolic acids and the stilbene polyphenol, resveratrol. The therapeutic potential of resveratrol, firstly in cancer chemoprevention and then later for cardioprotection, has stimulated many studies on the possible mechanisms of action. Further indications for resveratrol have been developed, including the prevention of age-related disorders such as neurodegenerative diseases, inflammation, diabetes and cardiovascular disease. These improvements are remarkably similar yet there is an important dichotomy: low doses improve cell survival as in cardio-and neuro-protection yet high doses increase cell death as in cancer treatment. Fewer studies have examined the responses to other components of red wine, but the results have, in general, been similar to resveratrol. If the non-alcoholic constitutents of red wine are to become therapeutic agents, their ability to get to the sites of action needs to be understood. This mini-review summarizes recent studies on the possible mechanisms of action, potential therapeutic uses and bioavailability of the non-alcoholic constitutents of alcoholic beverages, in particular resveratrol and other polyphenols.

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“…Resveratrol became popular when the consumption of red wine was linked with the term French Paradox [58]. A mild-to-moderate wine drinking habit attenuates cardiovascular, cerebrovascular, and peripheral vascular risk due to reduced platelet and monocyte adhesion, attenuates the risk of prostate as well as a variety of cancers including pancreatic, gastric, and thyroid cancer, and slows down some neurodegenerative diseases like Alzheimer diseases [8,20,33,35,46,48,59]. Among approximately 500 different antioxidants, recent studies revealed that resveratrol and proanthocyanidins are the two most important polyphenolic antioxidants present in wine that attenuate various health problems [12].…”

Section: Resveratrol Grapes Wine and French Paradoxmentioning

confidence: 99%

Longevity nutrients resveratrol, wines and grapes

2009

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A mild-to-moderate wine drinking has been linked with reduced cardiovascular, cerebrovascular, and peripheral vascular risk as well as reduced risk due to cancer. The reduced risk of cardiovascular disease associated with wine drinking is popularly known as French Paradox. A large number of reports exist in the literature indicating that resveratrol present in wine is primarily responsible for the cardioprotection associated with wine. Recently, resveratrol was shown to extend life span in yeast through the activation of longevity gene SirT1, which is also responsible for the longevity mediated by calorie restriction. This review summarizes the reports available on the functional and molecular biological aspects of resveratrol, wine and grapes in potentiating the longevity genes.

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The Relation to Alcohol to Arteriosclerosis.

Cited by 52 publications

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Physiology and pharmacology of alcohol: the imidazobenzodiazepine alcohol antagonist site on subtypes of GABA_A receptors as an opportunity for drug development?

Physiology and pharmacology of alcohol: the imidazobenzodiazepine alcohol antagonist site on subtypes of GABA_A receptors as an opportunity for drug development?

The Biological Responses to Resveratrol and Other Polyphenols From Alcoholic Beverages

Longevity nutrients resveratrol, wines and grapes

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The Relation to Alcohol to Arteriosclerosis.

Cited by 52 publications

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Physiology and pharmacology of alcohol: the imidazobenzodiazepine alcohol antagonist site on subtypes of GABAA receptors as an opportunity for drug development?

Physiology and pharmacology of alcohol: the imidazobenzodiazepine alcohol antagonist site on subtypes of GABAA receptors as an opportunity for drug development?

The Biological Responses to Resveratrol and Other Polyphenols From Alcoholic Beverages

Longevity nutrients resveratrol, wines and grapes

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Product

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Physiology and pharmacology of alcohol: the imidazobenzodiazepine alcohol antagonist site on subtypes of GABA_A receptors as an opportunity for drug development?

Physiology and pharmacology of alcohol: the imidazobenzodiazepine alcohol antagonist site on subtypes of GABA_A receptors as an opportunity for drug development?