The relation of total body potassium to height, weight, and age in normal adults

Boddy, K.; King, Priscilla C.; Hume, Robert; Weyers, Elspeth

doi:10.1136/jcp.25.6.512

Cited by 181 publications

(92 citation statements)

References 15 publications

(12 reference statements)

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“…Thomsen et al (1986) have shown that BMC/lean body mass (LBM) is an effective correction for both height and weight. LBM was caculated according to the equation of Boddy et al (1972) and has previously been shown to fit closely with LBM measured by dual photon absorptiometry . We used both BMC and BMC/ LBM measurements in the men studied.…”

Section: S and Methodsmentioning

confidence: 98%

Reduced bone mineral density in men following chemotherapy for Hodgkin's disease

Holmes

Whitehouse²,

Clark³

et al. 1994

Br J Cancer

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(Finkelstein et al., 1992). Men who undergo bilateral orchidectomy have a rapid and progressive loss of lumbar spine integral bone with time from orchidectomy (Stepan et al., 1989). In men with hyperprolactinaemic hypogonadism restoration of normal testicular function is assocated with a significant increase in cortical BMD (Greenspan et al., 1986). Siilarly, restoration of normal serum testosterone in men with idiopathic hypogonadotrophic hypogonadism is also associated with a significant increase in cortical BMD (Finkelstein et al., 1989 puted tomography. There was, however, a significant reduction in cortical and trabecular BMD in women with chemotherapy-induced premature ovarian failure compared with similarly treated women with normal ovarian function.We have studied BMD in 29 men in complete remission following treatment of Hodgkin's disease. We have studied the relationship between serum testosterone and BMD, and the effect on BMD of time elapsed since completion of chemotherapy, type of chemotherapy received and number of cycles of chemotherapy. S and methodsWe studied 29 caucasian men who had previously received chemotherapy for Hodg9in's disease. The study subjects were drawn from 50 consecutive men who presented to the Medical Oncology Dertment at Christie Hospital with newly diagosed Hodgkin's diseas and who were randomised to receive MVPP or hybrid chemotherapy. The 50 men took part in a study investigating the effects of MVPP and hybrid chemotherapy on gonadal function, and 29 of these men consented to have measurements of BMD performed. In the 29 men who underwent measurements of BMD, age at onset of chemotherapy was 31.0 ± 1.9 (mean + standard error, range 16.4-54.0) years. Twelve men had received a mean of 7.5 (range 5-8) cycles of MVPP (mustine 10 mg i.v. and vinblasin 10 mg i.v. on days 1 and 8 with procarbazine 150 mg daily and prednisolone 50 mg daily on days 1-14 of a 42 day cycle) and 17 men had received a mean of 7.5 (range 6-8) cycles of hybrid chemotherapy (vinblastine lOmgi.v. on day 1, with chlorambucil 1Omg daily, procarbazine 150 mg daily and prednisolone 50 mg daily on days 1-7, and etoposide 200mg m-2 i.v., viris 2 mg i.v. and doxorubicin 50 mg m-2i.v. on day 8 of a 28 day cycle). Twenty-four men received radiotherapy (15 to chest and mediastinum, eight to neck and one to axilla) but none in a radiation field which included the testes or the parts of the skeleton studied. All men were in complete remission at the time of study, and all had azoospermia.Blood samples were taken for estimation of serum testosterone, sex hormone-binding globulin (SHBG), LH and FSH. Seven men had blood samples taken on one occasion, 19 on two occasions and three on three occasions. There were therefore a total of 54 blood samples taken 2.7 ± 0.2

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Section: S and Methodsmentioning

confidence: 98%

Reduced bone mineral density in men following chemotherapy for Hodgkin's disease

Holmes

Whitehouse²,

Clark³

et al. 1994

Br J Cancer

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“…The gold standard for measuring body composition in a two-compartment model has been underwater weighing (UWW), which measures body density from which fat and lean mass content are estimated by assuming standard ®gures for density of these components (Siri, 1961). Other robust methods include the total-body potassium method, measuring intracellular¯uid by detecting the natural radioactive 40 K isotope (Boddy et al, 1972), and measurement of total body water by dilution of a deuterium-labeled water dose (Schoeller et al, 1980). More complicated multicompartment models of body composition that include bone mass are under development (Harsha & Bray, 1996).…”

Section: Introductionmentioning

confidence: 99%

Skinfold thickness measurements are better predictors of body fat percentage than body mass index in male Spanish children and adolescents

et al. 1998

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Objective: To develop equations, from some simple anthropometric measurements, for the prediction of body density from underwater weighing in male spanish children and adolescents. Subjects: One hundred and seventy-®ve males, aged 7.0±16.9 y, participated in this study, they were recruited from primary and secondary schools. Measurements: Body weight and height and skinfold thicknesses by anthropometry, body density by underwater weighing. Results: Correlations between body density and body mass index (BMI) were high until 14.0±16.9 y. Correlations between body density and log S 4 skinfolds were higher than those with BMI at all ages. Log S 4 skinfolds explained between 61% (14.0±16.9 y) and 68% (11.0±13.9 y) of the body density variance. Regression equations for body density from BMI and triceps skinfold thickness explained between 51% (14.0±16.9 y) and 68% (7.0±10.9 y) of the body density variance. Conclusions: The best estimators of body density in the children and adolescents studied were log S 4 skinfolds and a combination of BMI and triceps skinfold.

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“…In no subject was the measured TBK significantly less than both predicted normal values (Boddy et al, 1972). However, in two subjects (6 and 9) the measured value was less than that estimated from height and age only.…”

Section: Discussionmentioning

confidence: 64%

“…The procedure has been described in detail previously (Boddy et al, 1971). The measured TBK in each subject was compared with the expected normal values and range estimated from height and age and from height, weight, and age (Boddy et al, 1972). Exchangeable body potassium was measured by the general method of Davies and Robertson (1973) except that 43K alone was administered.…”

Section: Methodsmentioning

confidence: 99%

Total body and exchangeable potassium in chronic airways obstruction: a controversial area?

Boddy¹,

Davies²,

Howie³

et al. 1978

Thorax

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The relation of total body potassium to height, weight, and age in normal adults

Cited by 181 publications

References 15 publications

Reduced bone mineral density in men following chemotherapy for Hodgkin's disease

Reduced bone mineral density in men following chemotherapy for Hodgkin's disease

Skinfold thickness measurements are better predictors of body fat percentage than body mass index in male Spanish children and adolescents

Total body and exchangeable potassium in chronic airways obstruction: a controversial area?

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