The Relation of Serum Adiponectin and Resistin Concentrations with Metabolic Risk Factors

Ryu, Seong Tae; Park, Seok O; Kim, Se Hwa

doi:10.3803/jkes.2005.20.5.444

Cited by 7 publications

(3 citation statements)

References 26 publications

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“…Previous studies have suggested a relationship between inflammation and overweight or even morbid obesity in humans 19 . Indeed, fat cells, through the production of interleukins called adipokines and, more specifically, resistin, leptin and adiponectin, interfere with inflammatory processes associated with the use of simvastatin for the treatment of apical lesions 20 . Because simvastatin plays a role in the reduction of inflammation, it is possible to decrease the amount of cholesterols and interleukins to prevent bone resorption.…”

Section: Discussionmentioning

confidence: 99%

“…Based on this finding, research concerning the use of simvastatin and evaluation of oral health indicators, as conducted in the present study, could provide important data for understanding the cause/effect relationship between pulp tissue aggression and apical lesion progression. 20,21 Alterations in the cardiovascular system have been associated with dyslipidemia worldwide 24 . To treat these complications, simvastatin, a member of the statins group, has been widely used due to its low cost, easy acquisition and few side effects 25 .…”

Section: Discussionmentioning

confidence: 99%

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Effect of Simvastatin on induced apical periodontitis in rats: a tomographic and biochemical analysis

Pereira

Semenoff-Segundo

Silva

et al. 2016

Rev. odontol. UNESP

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ResumoIntrodução: A sinvastatina é uma das várias estatinas utilizadas no tratamento da hipercolesterolemia e, na odontologia, alguns estudos têm buscado relacioná-la ao reparo ósseo. Objetivo: Avaliar o efeito da sinvastatina na progressão da periodontite apical induzida em ratos. Material e método: Para tanto, 36 ratos Wistar, previamente selecionados, foram divididos em 3 grupos (N=12). Grupo Controle (GC); Grupo Periodontite Apical (GPA); Grupo Periodontite Apical Associada à Sinvastatina (GPAS). No primeiro dia do ensaio o GPA e o GPAS foram anestesiados e submetidos à abertura coronária do primeiro molar inferior direito. Durante trinta dias, o GPAS recebeu diariamente 6mg de sinvastatina, através de gavagem. No trigésimo primeiro dia, todos os grupos foram submetidos à coleta de sangue e a eutanásia. As mandíbulas foram removidas e fixadas em formol. Para a mensuração das regiões periapicais, foram realizadas tomografias. Além disso, avaliou-se a massa corporal, glicemia e o lipidograma. Os dados foram submetidos à análise estatística ANOVA de uma via e teste Post Hoc de Tukey (p<0,05). Resultado: Os resultados demonstram que o GPA (3,42±0,65) apresentou os maiores perímetros para espaço do ligamento periapical, seguido pelo GPAS (1,54±0,78) e GC (0,64±0,24), respectivamente (p<0,05). Em relação ao lipidograma percebe-se o efeito da sinvastatina avaliando-se a quantidade de glicose, triglicérides, HDL, VLDL (p<0,05). Para a massa corporal o GPA foi o que mais ganhou peso (264,75±44,11); seguido pelo GC (252,00±44,36); e GPAS (245,41±42,56). Os três grupos apresentaram diferenças estatísticas entre si, de forma decrescente (p<0,05). Conclusão: O uso da sinvastatina diminuiu a progressão do aumento do espaço do ligamento periapical em ratos.Descritores: Sinvastatina; ratos; periodontite apical; endodontia. AbstractIntroduction: Simvastatin is one of several statins that are used to treat hypercholesterolemia, and in dentistry, few studies have attempted to associate the administration of this compound with bone repair. Objective: To evaluate the effect of simvastatin on the progression of induced apical periodontitis in rats. Material and method: To this end, 36 male Wistar rats were divided into 3 groups (N=12): Induced Apical Periodontitis Associated with Simvastatin Group (APSG N=12), Induced Periodontitis Apical Induced Group (APG N=12) and Negative Control Group (CG). On the first day, APG and APSG were anesthetized, and the coronal opening of the mandibular first molar was performed. For thirty days, the APSG received 6 mg of simvastatin daily via gavage. On the thirty-first day, all groups underwent blood collection and euthanasia. The jaws were removed and fixed in formalin. CT scans were performed to measure the periapical regions. In addition, the body mass and lipid profile were analyzed. The data were subjected to statistical analysis (ANOVA and Tukey's test). Result: The APG (3.42±0.65) showed the highest perimeters for the space periapical ligament, followed by APSG (1.54±0.78) and CG (0.64±0....

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effect of Simvastatin on induced apical periodontitis in rats: a tomographic and biochemical analysis

Pereira

Semenoff-Segundo

Silva

et al. 2016

Rev. odontol. UNESP

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“…Therefore, it constitutes an essential natural defensive mechanism against T2DM and other cardiovascular diseases, mainly through regulating carbohydrates and fat catabolism in liver and skeletal muscles (20). Increased adipocyte deposition leads to a marked reduction in adiponectin levels in obese diabetic patients (21). Furthermore, adiponectin levels negatively correlate with insulin resistance (22,23 ‫املتوسط‬ ‫لرشق‬ ‫الصحية‬ ‫املجلة‬ ‫العرشون‬ ‫و‬ ‫احلادي‬ ‫املجلد‬ ‫السادس‬ ‫العدد‬…”

Section: Adipocyte Hormonesmentioning

confidence: 99%

Obesity-linked diabetes in the Arab world: a review

Abuyassin¹,

Laher²

2015

East Mediterr Health J

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The Arab world is experiencing an epidemic of obesity and type 2 diabetes mellitus. This review summarizes the major pathological factors linking obesity to diabetes, focussing on current epidemiological data related to obese diabetic patients in the Arab world, the etiology of the disease and the genetic determinants of diabetes and obesity. There are alarming data related to the rising prevalence of obesity and type 2 diabetes mellitus in children of Arab ethnicity. Replication studies identify several genetic variants in Arabs with obesitylinked diabetes. For example, variants of the ADIPOQ gene (the rs266729 single-nucleotide polymorphism) are associated with obesity and diabetes in various Arab countries. Gaps exist in our information about diabetes and obesity in Arab populations in relation to ethnic-specific cut-off points for diagnosis and treatment of diabetes. Further genome-wide association studies in obese and diabetic Arab populations could add to our understanding of the pathophysiology, prevention and reversal of this disease.

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Obesity-linked diabetes in the Arab world: a review

Abuyassin¹,

Laher²

2015

Easter Mediterr Health J

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The Relation of Serum Adiponectin and Resistin Concentrations with Metabolic Risk Factors

Abstract: -444 - ABSTRACTBackground: Adiponectin is a fat cell-secreted cytokine, which has been reported to improve insulin

Cited by 7 publications

References 26 publications

Effect of Simvastatin on induced apical periodontitis in rats: a tomographic and biochemical analysis

Effect of Simvastatin on induced apical periodontitis in rats: a tomographic and biochemical analysis

Obesity-linked diabetes in the Arab world: a review

Obesity-linked diabetes in the Arab world: a review

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