Obesity-linked diabetes in the Arab world: a review

Abuyassin, Bisher; Laher, Ismail

doi:10.26719/2015.21.420

Cited by 22 publications

(9 citation statements)

References 69 publications

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“…[39][40][41][42][43] We do not have any studies set in Yemen showing the prevalence of obesity among the general population, but among patients with diabetes, it is lower than that of neighboring countries in the gulf. 44 In 2 previous studies in Yemen, with the first done in 2014, the results showed the prevalence of patients with type 2 DM with a BMI≥ 25 to be 58.3% with 28.8% being obese. A three-year study published in 2020 did not show a significant increase in obesity among females with type 2 DM from the previous study (p value 0.117), but among the males with type 2 DM, the prevalence of obesity increased from 32.3% to 33% (p value 0.035).…”

Section: Discussionmentioning

confidence: 91%

Family History, Consanguinity and Other Risk Factors Affecting the Prevalence of Prediabetes and Undiagnosed Diabetes Mellitus in Overweight and Obese Yemeni Adults

Al-Sharafi¹,

Qais²,

Salem³

et al. 2021

DMSO

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Objective: Overweight and obese adults are at high risk for developing prediabetes and diabetes. The aim of this study was to measure the prevalence of prediabetes (pre-DM) and diabetes (DM) among Yemeni adults who were overweight or obese and had first-degree relatives with DM, consanguinity and other risk factors. Patients and Methods: This cross-sectional study included 612 adults, all with a BMI≥25 kg/ m 2 . BMI, blood pressure (BP) and waist circumference (WC) were measured in the clinic. Fasting blood glucose (FBG) was collected for all subjects. The patients either had first-degree relatives with diabetes or not, and the subjects answered a questionnaire regarding the consanguinity of their parents, exercise, khat chewing, smoking, and eating vegetables and fruits daily. Results: Of the 612 study participants (32% males and 68% females) aged 20-70 years old, 429 (70.1%) had a family history (FM) of DM ± consanguinity of parents, and 183 (29.9%) had no FM of diabetes. Multivariate analysis showed significant risk in those with class III obesity for pre-DM (AOR 3.10 95% CI 1.56-6.18 p value 0.001) and DM (AOR 3.35 95% CI 1.47-7.65 p value 0.004) and those who had siblings with DM had a risk for pre-DM (AOR 1.72 95% CI 1.09-2.71 p value 0.02) and DM (AOR 2.24 95% CI 1.25-4.0 p value 0.007). Khat chewing increased the risk for pre-DM (AOR 1.61 95% CI 1.04-2.48 p value 0.032) and for DM (AOR 2.09 95% CI 1.14-3.82 p value 0.017). Having consanguineous parents plus siblings with DM were associated with a higher risk of DM (p value 0.031). Conclusion:There is a high prevalence of pre-DM and undiagnosed DM among overweight and obese Yemeni individuals. Class III obesity, having siblings with DM, chewing khat, and having consanguineous parents plus siblings with DM all increased the risk. This group should be screened at an early age for early detection of pre-DM and DM.

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Section: Discussionmentioning

confidence: 91%

Family History, Consanguinity and Other Risk Factors Affecting the Prevalence of Prediabetes and Undiagnosed Diabetes Mellitus in Overweight and Obese Yemeni Adults

Al-Sharafi¹,

Qais²,

Salem³

et al. 2021

DMSO

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“…Other considerations such as multiple pregnancies and a lack of health education may be unique challenges in diabetes epidemic in Arab World. However, obesity represents a large component in the pathogenesis of T2DM (Abuyassin and Laher 2015) and is by far a key risk factor for increased prevalence of T2DM globally (Sigal et al 2004). A sedentary lifestyle, one of the most modifiable risk factors in Arab World, also contributes to the development of T2DM in adolescents.…”

Section: Diabetes Mellitusmentioning

confidence: 99%

Cardiovascular Risk Factors in Adolescents

Khaddam¹

2020

Handbook of Healthcare in the Arab World

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Cardiovascular diseases are the leading cause of death in the world, and the mortality rate due to these diseases in Arab World and Middle East region is among the highest anywhere. This high incidence of cardiovascular diseases in the Arab World is the greater abundance of cardiovascular risk factors in children and adolescents in this region compared to those in Western countries. Another contributing factor is the large adolescent population in most Arab countries.Major cardiovascular risk factors such as hypertension, type 2 DM (T2DM), and dyslipidemia in adolescents are strongly associated with severe obesity. The prevalence of obesity in the Gulf area is likely due to the unique lifestyles of adolescents in the region, such as sedentary lifestyles coupled with an excessive indulgence in unhealthy diets, the emerging use of tobacco products and the shisha (water pipe). Urgent educational programs are needed to reduce the acceleration of major cardiac risk factors in the region.

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“…These include type 2 diabetes mellitus (T2DM), dyslipidemia and accelerated atherosclerosis, coronary artery disease (CAD), hypertension (HTN), left ventricular hypertrophy, cor pulmonale, cardiomyopathy, pulmonary hypertension, obstructive sleep apnea, obesity hypoventilation syndrome, intracranial hypertension, stroke, reflux esophagitis, liver disorders (non-alcoholic steatohepatitis or NASH, cirrhosis, cholelithiasis, and gallbladder disease), cancers, and osteoarthritis. Obesity related reproductive complications in females include early puberty, anovulation, infertility, hyperandrogenism, and polycystic ovaries; while in males, there may be hypogonadotropic hypogonadism (23)(24)(25)(26)(27)(28).…”

Section: Comorbiditiesmentioning

confidence: 99%

Measuring obesity: Fat or fit!

Anaizi

2016

Ibnosina Journal of Medicine and Biomedical Sciences

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Obesity is widely recognized as a major global health challenge because of its strong association with multiple cardiometabolic risk factors including diabetes, hypertension, and coronary artery disease. It compromises the quality of life and shortens life expectancy. This minireview discusses firstly the physiological mechanisms involved in energy homeostasis including peptidergic signalling of hunger and satiety from the GI tract mediated by the gut hormones (ghrelin, CCK, PYY, GIP, GLP-1,), and the status of energy stores from the adipose tissue mediated primarily by leptin, secondly, the field methods used in clinical practice to estimate the degree of obesity and lastly, management of the obese patient.

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Obesity-linked diabetes in the Arab world: a review

Cited by 22 publications

References 69 publications

Family History, Consanguinity and Other Risk Factors Affecting the Prevalence of Prediabetes and Undiagnosed Diabetes Mellitus in Overweight and Obese Yemeni Adults

Family History, Consanguinity and Other Risk Factors Affecting the Prevalence of Prediabetes and Undiagnosed Diabetes Mellitus in Overweight and Obese Yemeni Adults

Cardiovascular Risk Factors in Adolescents

Measuring obesity: Fat or fit!

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