The relation of neutrophil‐to‐lymphocyte ratio, platelet‐to‐lymphocyte ratio, and mean platelet volume with the presence and severity of Behçet's syndrome

Abstract

Behçet's syndrome (BS) is associated with chronic inflammation and endothelial dysfunction. Although there have been extensive investigations on neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and mean platelet volume (MPV) in many diseases, their roles in BS is unclear. The purpose of the present study was to evaluate NLR, PLR, and MPV levels in BS patients and explore their clinical significance. The study included 254 patients with BS and 173 healthy individuals. Age, sex, age of onset, duration of disease, smoking, Behçet activity score, total white blood counts, neutrophil, platelet, and T lymphocyte counts of the patients were recorded. White blood cell (WBC), neutrophil, platelet, NLR, and PLR were significantly higher in patients with BS when compared with healthy controls (all p < 0.001). Lymphocyte counts and MPVs of the BS group were not statistically different from healthy controls (all p > 0.05). In the BS group, PLR and MPV were significantly different among the three severity groups (p = 0.037 and p = 0.016, respectively). We showed that any laboratory markers were not associated with joint, eye, central nervous system, large vessel, or gastrointestinal involvement in BS. NLR was shown to be an independent factor for BS by multivariate analysis. We suggest that NLR can be considered to be a diagnostic criterion of BS given the support of the findings from larger prospective studies.

The role of mean platelet volume, platelet distribution width and platelet / lymphocyte ratio in development of cerebral venous thrombosis

“…On the other hand, the relationship between high PLR and venous thrombosis development is much more complex and it has not been completely understood yet. With this purpose, various studies were conducted on development of venous thrombosis in Behçet disease, pulmonary embolism and various oncological diseases [27][28][29][30] . In the study by Alan et al, the PLR value was found higher in the group with Behçet disease.…”

Evaluation of Platelet Indices in Young Male Patients with Hepatitis C

“…Therefore, the platelet-to-lymphocyte ratio (PLR) may be altered by these disorders. PLR has been shown to be associated with inflammation and inflammation severity and is also described as an independent predictor of some infectious diseases such as infective endocarditis [15][16][17]. In this study, in light of the fact that platelet counts and sizes or lymphocyte counts may be altered in patients with HCV infection depending upon the severity of inflammation or fibrosis, we aimed to investigate the values and the roles of platelet indices and PLR in male patients with HCV infection compared with healthy controls.…”

“…Abnormal platelet indices have also been found to be associated with more severe illness and higher risk of death in intensive care unit patients [14]. Not only platelet counts, but also lymphocyte counts can be affected by chronic inflammatory diseases, infectious diseases, malignancies and myeloproliferative disorders [15][16][17]. Therefore, the platelet-to-lymphocyte ratio (PLR) may be altered by these disorders.…”

Uygun maliyetli ve kolay ulaşılabilir bir belirteç olarak platelet/lenfosit oranı

“…PLR has been evaluated in patients with several diseases including chronic inflamatory diseases, malignancies, myeloproliferative disorders, cardiovasculer diseases and infectious diseases [1][2][3][4][5][6][7][8][9][10][11][12][13] .…”

“…Furthermore, elevated PLR levels have been shown in patients with several diseases such as cancer (e.g., prostate, colorectal, cervical, ovarian, malignant pleural mesothelioma and surgically resected gastrointestinal stromal tumors), peripheral artery disease, hypertension, coronary artery disease, limb ischemia, poor prognostic myocardial infraction, infective endocarditis, exacerbation of chronic obstructive pulmonary disease (COPD), systemic lupus erythematosus (SLE), psoriasis vulgaris, Behçet's syndrome, pseudoexfoliation syndrome [1][2][3][4][5][6][7][8][9][10][11][12][13] . On the contrary, reduced PLR levels have been reported in patients with obstructive sleep apnea syndrome (OSAS) 6 .…”