The role of mean platelet volume, platelet distribution width and platelet / lymphocyte ratio in development of cerebral venous thrombosis

Bolayir, Aslı; Gökçe, Şeyda Figül

doi:10.7197/223.v39i32356.369336

Cited by 11 publications

(8 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Recently, it has been showed that, the changes of lymphocyte count, subtypes of leukocytes, is associated with both cardiovascular diseases and other neurological diseases 13 . Lymphocytes have a controversial role in the inflammation after AIS.…”

Section: Discussionmentioning

confidence: 99%

The relationship between lymphocyte / monocyte ratio and short-term mortality in acute ischemic stroke patients.

Bolayir¹

2018

Cumhuriyet Medical Journal

Self Cite

View full text Add to dashboard Cite

The lymphocyte / monocyte ratio (LMR) obtained by dividing the number of lymphocytes by monocyte number is considered a new marker of inflammation. Recent studies have found an inverse relationship between LMR levels and 3-month functional recovery after acute ischemic stroke (AIS). Our aim in this study is to determine the role of LMR in the short-term mortality of AIS patients. Method: Our study is a single centered retrospective study. 508 patients with AIS, who presented to our clinic between January 2011 and December 2017 and 512 healthy control with similar age and sex were included to our study. Results: While monocyte count was higher in the patient group; lymphocyte count and LMR levels were higher in the control group. The patient group was then divided into two subgroups according to 30-day mortality. When the patients in the first group survivied (n = 396), the patients in the second group died within 30 days after AIS(n = 112). In the second group, the lymphocyte count and LMR levels were lower when the monocyte count was elevated (p < 0.001). Logistic regression analysis showed that uric acid, CRP and LMR are independent variables for the occurrence of 30-day mortality. In addition, ROC analysis revealed that an LMR value below 2.95 can be used as a marker for the short-term mortality of AIS (AUC:0.77, %95 CI:0.67-0.86,sensitivity:%72.6, specificity: %80.7). Conclusions: Based on our results, it can be concluded that lower LMO levels in patients with AIS are related to shortterm mortality.

show abstract

Section: Discussionmentioning

confidence: 99%

The relationship between lymphocyte / monocyte ratio and short-term mortality in acute ischemic stroke patients.

Bolayir¹

2018

Cumhuriyet Medical Journal

Self Cite

View full text Add to dashboard Cite

show abstract

“…These cytokines contribue to the development of atherosclerosis via stimulating smooth muscle and interstitial cell proliferation. Additionally, the lymphocyte count changes has been revelaed to be related to both cardiovascular diseases and other neurological diseases 18 .…”

Section: Discussionmentioning

confidence: 99%

Can lymphocyte to monocyte ratio be used as a predictor of atherosclerotic carotid plaques in elderly adults?

Bolayir

Bolayır²

2018

Cumhuriyet Medical Journal

View full text Add to dashboard Cite

The aim of our study was to determine retrospectively the association of LMR with carotid stenosis, evaluated by carotid artery doppler ultrasonography. Method: Our study included 102 patients, aged ≥ 65 years, hospitalized in our clinic from January 2011 to December 2017. Blood samples were taken from all of the patients to determine the levels of white blood cell subtypes. LMR was calculated as the ratio of lymphocyte count to monocyte count. Patients also underwent carotid artery doppler ultrasonography to define the presence of carotid stenosis. Results: After dividing the patient group into two subgroups according to carotid stenosis, the patients with severe stenosis(carotid stenosis> 50%)(n=42) had lower lymphocyte count and LMR value but higher monocyte count. Then the patient group with carotid stenosis> 50% were divided into two subgroups again. While a statistically significant difference was found between the LMR values of these 3 groups, this difference was in favor of the first group(carotis stenosis ˂50%). The optimum cutoff LMR values was determined as 2.49 with a sensitivity of 72.6% and a specificity of 80.7%. Conclusions: Lower levels of LMR can be used as a strong predictor of the presence of severe carotid stenosis in elderly adults.

show abstract

“…This diagnostic case includes heterogeneity among any could-be pathogenetic factors, even derived from noncardiac effects. The most notorious one is impaired endothelium in the collateral coronary circulation [8,9].…”

Section: Discussionmentioning

confidence: 99%

Nesfatin-1 Levels in Cardiac Syndrome X Patients

Bolayır¹

2018

Cardiol Cardiovascmed

View full text Add to dashboard Cite

Background & Aim: Nesfatin-1 is a novel anorectic neuropeptide with potent metabolic regulatory effects. Our aim is to investigate the association of nesfatin-1 levels and cardiac syndrome X (CSX). Methods:The study group consist of 80 patients who underwent coronary angiography and were diagnosed as CSX according to the presence of exercise-induced typical angina pectoris and ischemia on myocardial perfusion scintigraphy with angiographically normal coronary arteries. For control subjects, we recruited 80 healthy genderand age-matched individuals who were seen for health check-ups. Results:The cases had significantly lower levels of Serum Nesfatin-1 than the subjects (p < 0.001). There is significant correlation between low Nesfatin-1 levels and the CSX presence (OR, 0.982; 95% CI; 0.969-0.995; p=0.005). Conclusion:The study results of CSX indicated lower levels of serum Nesfatin-1 compared to the control group.Nesfatin-1 might function as a pathogenic factor for CSX through an inflammatory response as well as an impaired endothelium. We commend this labor to you and expect further research from you on the association of Nesfatin-1 and CSX.

show abstract

The role of mean platelet volume, platelet distribution width and platelet / lymphocyte ratio in development of cerebral venous thrombosis

Cited by 11 publications

References 27 publications

The relationship between lymphocyte / monocyte ratio and short-term mortality in acute ischemic stroke patients.

The relationship between lymphocyte / monocyte ratio and short-term mortality in acute ischemic stroke patients.

Can lymphocyte to monocyte ratio be used as a predictor of atherosclerotic carotid plaques in elderly adults?

Nesfatin-1 Levels in Cardiac Syndrome X Patients

Contact Info

Product

Resources

About